Rubiaceae-Type Cyclopeptides from Galianthe thalictroides

Two Rubiaceae-type cyclopeptides, 6-O-methylbouvardin (1) and the new cyclopeptide 5β-hydroxy-RA-III (2), were isolated from the roots of Galianthe thalictroides. Employing the sulforhodamine B assay, compounds 1 and 2 were tested in vitro against three cancer cell lines786-0 (kidney carcinoma), PC...

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Bibliographic Details
Published in:	Journal of natural products (Washington, D.C.) Vol. 79; no. 4; pp. 1165 - 1169
Main Authors:	Figueiredo, Patrícia O, Matos, Maria de Fatima C, Perdomo, Renata T, Kato, Wilson H, Barros, Marcos Vinícius G. O, Garcez, Fernanda R, Garcez, Walmir S
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society and American Society of Pharmacognosy 22-04-2016
Subjects:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Brazil Cell Survival - drug effects Drug Screening Assays, Antitumor HT29 Cells Humans Male Molecular Structure Nuclear Magnetic Resonance, Biomolecular Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Plant Extracts - chemistry Plant Roots - chemistry Rubiaceae - chemistry Brazil
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Summary:	Two Rubiaceae-type cyclopeptides, 6-O-methylbouvardin (1) and the new cyclopeptide 5β-hydroxy-RA-III (2), were isolated from the roots of Galianthe thalictroides. Employing the sulforhodamine B assay, compounds 1 and 2 were tested in vitro against three cancer cell lines786-0 (kidney carcinoma), PC-3 (prostate carcinoma), and HT-29 (colon carcinoma)and showed GI50 values ranging from 0.06 to 1.80 μg mL–1. This is the first report on the isolation of Rubiaceae-type cyclopeptides from a genus other than Rubia or Bouvardia.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0163-3864 1520-6025
DOI:	10.1021/acs.jnatprod.5b00849