Search Results - "Barros, Luciana C"
-
1
A comparative analysis of noise properties of stochastic binary models for a self-repressing and for an externally regulating gene
Published in Mathematical biosciences and engineering : MBE (13-08-2020)“…This manuscript presents a comparison of noise properties exhibited by two stochastic binary models for: (i) a self-repressing gene; (ii) a repressed or…”
Get full text
Journal Article -
2
-
3
Modeling Patient-Specific CAR-T Cell Dynamics: Multiphasic Kinetics via Phenotypic Differentiation
Published in Cancers (14-11-2022)“…Chimeric Antigen Receptor (CAR)-T cell immunotherapy revolutionized cancer treatment and consists of the genetic modification of T lymphocytes with a CAR gene,…”
Get full text
Journal Article -
4
Protocol for the establishment of a serine integrase-based platform for functional validation of genetic switch controllers in eukaryotic cells
Published in PloS one (23-05-2024)“…Serine integrases (Ints) are a family of site-specific recombinases (SSRs) encoded by some bacteriophages to integrate their genetic material into the genome…”
Get full text
Journal Article -
5
A Stochastic Binary Model for the Regulation of Gene Expression to Investigate Responses to Gene Therapy
Published in Cancers (27-01-2022)“…In this manuscript, we use an exactly solvable stochastic binary model for the regulation of gene expression to analyze the dynamics of response to a treatment…”
Get full text
Journal Article -
6
In vitro activity of phospholipase A2 and of peptides from Crotalus durissus terrificus venom against amastigote and promastigote forms of Leishmania (L.) infantum chagasi
Published in The journal of venomous animals and toxins including tropical diseases (24-11-2015)“…American visceral leishmaniasis is caused by the intracellular parasite Leishmania (L.) infantum chagasi, and transmitted by the sand fly Lutzomyia…”
Get full text
Journal Article -
7
CARTmath—A Mathematical Model of CAR-T Immunotherapy in Preclinical Studies of Hematological Cancers
Published in Cancers (11-06-2021)“…Immunotherapy has gained great momentum with chimeric antigen receptor T cell (CAR-T) therapy, in which patient’s T lymphocytes are genetically manipulated to…”
Get full text
Journal Article -
8
In vitro activity of phospholipase A 2 and of peptides from Crotalus durissus terrificus venom against amastigote and promastigote forms of Leishmania (L.) infantum chagasi
Published in The journal of venomous animals and toxins including tropical diseases (01-12-2015)“…Abstract Background American visceral leishmaniasis is caused by the intracellular parasiteLeishmania (L.) infantum chagasi, and transmitted by the sand fly…”
Get full text
Journal Article -
9
Abnormal Long Non-Coding RNAs Expression Patterns Have the Potential Ability for Predicting Survival and Treatment Response in Breast Cancer
Published in Genes (29-06-2021)“…Abnormal long non-coding RNAs (lncRNAs) expression has been documented to have oncogene or tumor suppressor functions in the development and progression of…”
Get full text
Journal Article -
10
Genetic switches designed for eukaryotic cells and controlled by serine integrases
Published in Communications biology (22-05-2020)“…Recently, new serine integrases have been identified, increasing the possibility of scaling up genomic modulation tools. Here, we describe the use of…”
Get full text
Journal Article -
11
Mechanisms of resistance to CAR-T cell immunotherapy: Insights from a mathematical model
Published in Applied mathematical modelling (01-01-2024)“…Chimeric Antigen Receptor (CAR)-T cell therapy long-term follow-up studies revealed non-durable remissions in a significant number of patients. Some of the…”
Get full text
Journal Article -
12
CART math -A Mathematical Model of CAR-T Immunotherapy in Preclinical Studies of Hematological Cancers
Published in Cancers (11-06-2021)“…Immunotherapy has gained great momentum with chimeric antigen receptor T cell (CAR-T) therapy, in which patient's T lymphocytes are genetically manipulated to…”
Get full text
Journal Article -
13
In vitro activity of phospholipase A sub(2) and of peptides from Crotalus durissus terrificus venom against amastigote and promastigote forms of Leishmania (L.) infantum chagasi
Published in The journal of venomous animals and toxins including tropical diseases (01-01-2015)“…American visceral leishmaniasis is caused by the intracellular parasiteLeishmania (L.) infantum chagasi, and transmitted by the sand fly Lutzomyia longipalpis…”
Get full text
Journal Article -
14
Protocol for the establishment of a serine integrase-based platform for functional validation of genetic switch controllers in eukaryotic cells
Published in PloS one (01-01-2024)“…Serine integrases (Ints) are a family of site-specific recombinases (SSRs) encoded by some bacteriophages to integrate their genetic material into the genome…”
Get full text
Journal Article -
15
Abstract P4-12-14: Assessing patients perceptions on hormone therapy for breast cancer: Insights from a Brazilian patient group
Published in Cancer research (Chicago, Ill.) (15-02-2022)“…Introduction Breast cancer has a high incidence in the population, and it still is a major cause of mortality among women. About 2/3 of these tumors express…”
Get full text
Journal Article