Search Results - "Barro, Christian"

Serum neurofilament light levels in normal aging and their association with morphologic brain changes by Khalil, Michael, Pirpamer, Lukas, Hofer, Edith, Voortman, Margarete M., Barro, Christian, Leppert, David, Benkert, Pascal, Ropele, Stefan, Enzinger, Christian, Fazekas, Franz, Schmidt, Reinhold, Kuhle, Jens

“…Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured not only in cerebrospinal fluid but also in serum, which allows for…”
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Blood neurofilament light chain as a biomarker of MS disease activity and treatment response by Kuhle, Jens, Kropshofer, Harald, Haering, Dieter A, Kundu, Uma, Meinert, Rolf, Barro, Christian, Dahlke, Frank, Tomic, Davorka, Leppert, David, Kappos, Ludwig

“…OBJECTIVETo assess the value of blood neurofilament light chain (NfL) as a biomarker of recent, ongoing, and future disease activity and tissue damage and its…”
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Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis by Barro, Christian, Benkert, Pascal, Disanto, Giulio, Tsagkas, Charidimos, Amann, Michael, Naegelin, Yvonne, Leppert, David, Gobbi, Claudio, Granziera, Cristina, Yaldizli, Özgür, Michalak, Zuzanna, Wuerfel, Jens, Kappos, Ludwig, Parmar, Katrin, Kuhle, Jens

“…See Giovannoni (doi:10.1093/brain/awy200) for a scientific commentary on this article. Biomarkers of tissue damage in multiple sclerosis are urgently needed…”
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Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa by Kuhle, Jens, Barro, Christian, Andreasson, Ulf, Derfuss, Tobias, Lindberg, Raija, Sandelius, Åsa, Liman, Victor, Norgren, Niklas, Blennow, Kaj, Zetterberg, Henrik

“…Neuronal damage is the morphological substrate of persisting neurological disability. Neurofilaments (Nf) are specific cytoskeletal proteins of neurons and…”
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Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis by Disanto, Giulio, Barro, Christian, Benkert, Pascal, Naegelin, Yvonne, Schädelin, Sabine, Giardiello, Antonella, Zecca, Chiara, Blennow, Kaj, Zetterberg, Henrik, Leppert, David, Kappos, Ludwig, Gobbi, Claudio, Kuhle, Jens, Kuhle, Jens, Lorscheider, Johannes, Yaldizli, Özgür, Derfuss, Tobias, Kappos, Ludwig, Disanto, Giulio, Zecca, Chiara, Gobbi, Claudio, Benkert, Pascal, Achtnichts, Lutz, Nedeltchev, Krassen, Kamm, Christian P, Salmen, Anke, Chan, Andrew, Lalive, Patrice H, Pot, Caroline, Schluep, Myriam, Granziera, Cristina, Du Pasquier, Renaud, Müller, Stefanie, Vehoff, Jochen

“…Objective Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in…”
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Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD by Watanabe, Mitsuru, Nakamura, Yuri, Michalak, Zuzanna, Isobe, Noriko, Barro, Christian, Leppert, David, Matsushita, Takuya, Hayashi, Fumie, Yamasaki, Ryo, Kuhle, Jens, Kira, Jun-ichi

“…OBJECTIVETo test the hypothesis that serum levels of glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL), which are an intermediate…”
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Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis by Siller, Nelly, Kuhle, Jens, Muthuraman, Muthuraman, Barro, Christian, Uphaus, Timo, Groppa, Sergiu, Kappos, Ludwig, Zipp, Frauke, Bittner, Stefan

“…Background: Monitoring neuronal injury remains one key challenge in early relapsing-remitting multiple sclerosis (RRMS) patients. Upon axonal damage,…”
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Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis by Feneberg, Emily, Oeckl, Patrick, Steinacker, Petra, Verde, Federico, Barro, Christian, Van Damme, Philip, Gray, Elizabeth, Grosskreutz, Julian, Jardel, Claude, Kuhle, Jens, Koerner, Sonja, Lamari, Foudil, Amador, Maria del Mar, Mayer, Benjamin, Morelli, Claudia, Muckova, Petra, Petri, Susanne, Poesen, Koen, Raaphorst, Joost, Salachas, François, Silani, Vincenzo, Stubendorff, Beatrice, Turner, Martin R, Verbeek, Marcel M, Weishaupt, Jochen H, Weydt, Patrick, Ludolph, Albert C, Otto, Markus

“…OBJECTIVETo examine neurofilament (Nf) concentrations according to symptom onset and clinical diagnostic certainty categories of amyotrophic lateral sclerosis…”
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Fluid biomarker and electrophysiological outcome measures for progressive MS trials by Barro, Christian, Leocani, Letizia, Leppert, David, Comi, Giancarlo, Kappos, Ludwig, Kuhle, Jens

“…Progressive multiple sclerosis (MS) is characterized by insidious clinical worsening that is difficult to accurately quantify and predict. Biofluid markers and…”
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Serum neurofilament light chain in chronic inflammatory demyelinating polyneuropathy by Lieverloo, Gwen G. A., Wieske, Luuk, Verhamme, Camiel, Vrancken, Alexander F. J., Doorn, Pieter A., Michalak, Zuzanna, Barro, Christian, Schaik, Ivo N., Kuhle, Jens, Eftimov, Filip

“…Axonal damage in chronic inflammatory demyelinating polyneuropathy (CIDP) is the main predictor of poor outcome. We hypothesized that serum neurofilament light…”
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Fingolimod in children with Rett syndrome: the FINGORETT study by Naegelin, Yvonne, Kuhle, Jens, Schädelin, Sabine, Datta, Alexandre N, Magon, Stefano, Amann, Michael, Barro, Christian, Ramelli, Gian Paolo, Heesom, Kate, Barde, Yves-Alain, Weber, Peter, Kappos, Ludwig

“…Rett syndrome (RS) is a severe neurodevelopmental disorder for which there is no approved therapy. This study aimed to assess safety and efficacy of oral…”
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Serum neurofilament light chain levels associations with gray matter pathology: a 5‐year longitudinal study by Jakimovski, Dejan, Kuhle, Jens, Ramanathan, Murali, Barro, Christian, Tomic, Davorka, Hagemeier, Jesper, Kropshofer, Harald, Bergsland, Niels, Leppert, David, Dwyer, Michael G., Michalak, Zuzanna, Benedict, Ralph H. B., Weinstock‐Guttman, Bianca, Zivadinov, Robert

“…Background Gray matter (GM) pathology is closely associated with physical and cognitive impairment in persons with multiple sclerosis (PwMS). Similarly, serum…”
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Serum Neurofilament Light Chain Levels Are Related to Small Vessel Disease Burden by Duering, Marco, Konieczny, Marek J, Tiedt, Steffen, Baykara, Ebru, Tuladhar, Anil Man, Leijsen, Esther van, Lyrer, Philippe, Engelter, Stefan T, Gesierich, Benno, Achmüller, Melanie, Barro, Christian, Adam, Ruth, Ewers, Michael, Dichgans, Martin, Kuhle, Jens, de Leeuw, Frank-Erik, Peters, Nils

“…Neurofilament light chain (NfL) is a blood marker for neuroaxonal damage. We assessed the association between serum NfL and cerebral small vessel disease…”
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Validation of Two Kinetic Assays for the Quantification of Endotoxin in Human Serum by Barro, Christian, Paul, Anu, Saleh, Fermisk, Chitnis, Tanuja, Weiner, Howard L.

“…Background: There is an emerging evidence of the role of the microbiome in neurological diseases. Endotoxin is a component of gram-negative bacteria and…”
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Blood neurofilament light as a potential endpoint in Phase 2 studies in MS by Sormani, Maria Pia, Haering, Dieter A., Kropshofer, Harald, Leppert, David, Kundu, Uma, Barro, Christian, Kappos, Ludwig, Tomic, Davorka, Kuhle, Jens

“…Objectives To assess whether neurofilament light chain (NfL) could serve as an informative endpoint in Phase 2 studies in patients with relapsing–remitting…”
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Serum Neurofilament Light Chain Is Associated with Incident Lacunes in Progressive Cerebral Small Vessel Disease by Peters, Nils, van Leijsen, Esther, Tuladhar, Anil M., Barro, Christian, Konieczny, Marek J., Ewers, Michael, Lyrer, Philippe, Engelter, Stefan T., Kuhle, Jens, Duering, Marco, de Leeuw, Frank-Erik

“…Background and Purpose Serum neurofilament light (NfL)-chain is a circulating marker for neuroaxonal injury and is also associated with severity of cerebral…”
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Impact of parturition on maternal cardiovascular and neuronal integrity in a high risk cohort - a prospective cohort study by Evers, Katrina Suzanne, Huhn, Evelyn Annegret, Fouzas, Sotirios, Barro, Christian, Kuhle, Jens, Fisch, Urs, Bernasconi, Luca, Lapaire, Olav, Wellmann, Sven

“…To better understand the profound multisystem changes in maternal physiology triggered by parturition, in particular in the underexplored neuronal system, by…”
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Neurofilament Light Chain: Blood Biomarker of Neonatal Neuronal Injury by Depoorter, Antoinette, Neumann, Roland P, Barro, Christian, Fisch, Urs, Weber, Peter, Kuhle, Jens, Wellmann, Sven

“…Neurofilament light chain (NfL) is a highly promising biomarker of neuroaxonal injury that has mainly been studied in adult neurodegenerative disease. Its…”
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Reader Response: Blood Neurofilament Light in Progressive Multiple Sclerosis: Post Hoc Analysis of 2 Randomized Controlled Trials by Barro, Christian

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Biomarkers of treatment response in patients with progressive multiple sclerosis treated with high‐dose pharmaceutical‐grade biotin (MD1003) by Collongues, Nicolas, Kuhle, Jens, Tsagkas, Charidimos, Lamy, Julien, Meyer, Nicolas, Barro, Christian, Parmar, Katrin, Amann, Michael, Wuerfel, Jens, Kappos, Ludwig, Moreau, Thibault, Seze, Jerome

“…Background High‐dose pharmaceutical‐grade biotin (MD1003) has positive effects on disability in progressive multiple sclerosis (PMS), but its mechanism of…”
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