Search Results - "Barritt, G J"

Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins by Scrimgeour, N., Litjens, T., Ma, L., Barritt, G. J., Rychkov, G. Y.

“…Two cellular proteins, stromal interaction molecule 1 (STIM1) and Orai1, are recently discovered essential components of the Ca 2+ release activated Ca 2+…”
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Curcumin inhibits activation of TRPM2 channels in rat hepatocytes by Kheradpezhouh, E, Barritt, G J, Rychkov, G Y

“…Oxidative stress is a hallmark of many liver diseases including viral and drug-induced hepatitis, ischemia-reperfusion injury, and non-alcoholic…”
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Regulation of Orai1/STIM1 mediated ICRAC by intracellular pH by Gavriliouk, D., Scrimgeour, N. R., Grigoryev, S., Ma, L., Zhou, F. H., Barritt, G. J., Rychkov, G. Y.

“…Ca 2+ release activated Ca 2+ (CRAC) channels composed of two cellular proteins, Ca 2+ -sensing stromal interaction molecule 1 (STIM1) and pore-forming Orai1,…”
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TRPC1 Ca(2+)-permeable channels in animal cells by Rychkov, G, Barritt, G J

“…The full-length transient receptor (TRPC)1 polypeptide is composed of about 790 amino acids, and several splice variants are known. The predicted structure and…”
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Insulin potentiates EGFR activation and signaling in fibroblasts by Chong, M.P., Barritt, G.J., Crouch, M.F.

“…Insulin is an essential hormone for cell growth and potentiates the mitogenic actions of multiple growth factors, including EGF. While potentiation has been…”
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Receptor-activated Ca2+ inflow in animal cells: a variety of pathways tailored to meet different intracellular Ca2+ signalling requirements by Barritt, G J

“…Receptor-activated Ca2+ channels (RACCs) play a central role in regulation of the functions of animal cells. Together with voltage-operated Ca2+ channels…”
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Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow by BERVEN, L. A, BARRITT, G. J

“…The ability of 1-[6-[[17 beta-3-methoxyestra-1,3,5(10)-trien-17- yl]amino]hexyl]-1H-pyrrole-2,5-dione (U73122), an inhibitor of phospholipase C (Smith et al.,…”
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The predominant role of IP3 type 1 receptors in activation of store-operated Ca2+ entry in liver cells by Jones, L., Ma, L., Castro, J., Litjens, T., Barritt, G.J., Rychkov, G.Y.

“…Physiologically, hormone induced release of Ca2+ from intracellular stores occurs in response to inositol 1,4,5-trisphosphate (IP3) binding to its receptors…”
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Evidence that 2-aminoethyl diphenylborate is a novel inhibitor of store-operated Ca2+ channels in liver cells, and acts through a mechanism which does not involve inositol trisphosphate receptors by Gregory, R B, Rychkov, G, Barritt, G J

“…The compound 2-aminoethyl diphenylborate (2-APB), an inhibitor of Ins(1,4,5)P(3) receptor action in some cell types, has been used to assess the role of…”
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Store-activated Ca2+ inflow in Xenopus laevis oocytes: inhibition by primaquine and evaluation of the role of membrane fusion by Gregory, R B, Barritt, G J

“…The role of membrane fusion in the activation of store-activated Ca2+ channels (SACCs) in the plasma membrane of Xenopus laevis oocytes was investigated with…”
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A diacylglycerol-activated Ca2+ channel in PC12 cells (an adrenal chromaffin cell line) correlates with expression of the TRP-6 (transient receptor potential) protein by Tesfai, Y, Brereton, H M, Barritt, G J

“…The structures, and mechanisms of activation, of plasma membrane intracellular-messenger-activated, non-selective cation channels in animal cells are not well…”
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The roles of phospholipase D and a GTP-binding protein in guanosine 5'-[γ-thio]triphosphate-stimulated hydrolysis of phosphatidylcholine in rat liver plasma membranes by HURST, K. M, HUGHES, B. P, BARRITT, G. J

“…1. Guanosine 5'-[gamma-thio]triphosphate (GTP[S]) stimulated by 50% the rate of release of [3H]choline and [3H]phosphorylcholine in rat liver plasma membranes…”
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Increasing cycles of intermittent ischemia can effectively maintain liver function during the acute phase of ischemia reperfusion injury by promotion of bile flow and reduction in bile salt toxicity by Peters, J, Nieuwenhuijs, V B, Morphett, A, Porte, R J, Padbury, R T A, Barritt, G J

“…Intermittent ischemia (INT) can improve liver function following inflow occlusion. The aim was to test whether the number of cycles of INT can be increased…”
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A slowly ADP-ribosylated pertussis-toxin-sensitive GTP-binding regulatory protein is required for vasopressin-stimulated Ca2+ inflow in hepatocytes by BERVEN, L. A, HUGHES, B. P, BARRITT, G. J

“…The roles of heterotrimeric GTP-binding regulatory proteins (G-proteins) and inositol polyphosphates in the mechanism by which vasopressin stimulates Ca2+…”
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Plasma membrane Ca2+ release–Activated Ca2+ channels with a high selectivity for Ca2+ identified by patch-clamp recording in rat liver cells by Rychkov, Grigori, Brereton, Helen M., Harland, M.Lyn, Barritt, Gregory J.

“…Repetitive waves of increased cytoplasmic Ca2+ concentration play a central role in the process by which hormones regulate liver function. Maintenance of these…”
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Does a decrease in subplasmalemmal Ca2+ explain how store-operated Ca2+ channels are opened? by Barritt, G J

“…The phenomenon of store-activated Ca2+ inflow (capacitative Ca2+ entry) in which the depletion of Ca2+ in the endoplasmic reticulum (ER) increases the…”
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Maitotoxin activates an endogenous non-selective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells by Brereton, Helen M, Chen, Jinglong, Rychkov, Grigori, Harland, M.Lyn, Barritt, Gregory J

“…The structures and mechanisms of activation of non-selective cation channels (NSCCs) are not well understood although NSCCs play important roles in the…”
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Intracellular free calcium and inositol polyphosphate action as potential targets in the ageing process by Barritt, G J

“…The concentration of free Ca2+ in the cell cytoplasm is likely to be the most important parameter which should be considered in assessing the contribution of…”
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Effects of electrical stimulation and an intracellular calcium chelator on calcium movement in suspensions of isolated myocardial muscle cells by Barritt, G J, Lee, A M

“…The procedure of Haworth RA, Hunter DR and Berkoff HA (J Mol Cell Cardiol, 1980; 12:715-23) for the isolation of myocardial muscle cells from rat hearts has…”
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Evidence that store-operated Ca2+ channels are more effective than intracellular messenger-activated non-selective cation channels in refilling rat hepatocyte intracellular Ca2+ stores by Gregory, R B, Sykiotis, D, Barritt, G J

“…Liver cells possess store-operated Ca2+ channels (SOCs) with a high selectivity for Ca2+ compared with Na+, and several types of intracellular…”
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