Search Results - "Barrio‐Hernandez, Inigo"

Individual COVID‐19 disease trajectories revealed by plasma proteomics by Memon, Danish, Barrio‐Hernandez, Inigo, Beltrao, Pedro

“…Since the start of 2020, the world has been upended by the pandemic caused by the severe acute respiratory coronavirus type 2 (SARS‐CoV‐2), the causative agent…”
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SARS‐CoV‐2 infection remodels the host protein thermal stability landscape by Selkrig, Joel, Stanifer, Megan, Mateus, André, Mitosch, Karin, Barrio‐Hernandez, Inigo, Rettel, Mandy, Kim, Heeyoung, Voogdt, Carlos G P, Walch, Philipp, Kee, Carmon, Kurzawa, Nils, Stein, Frank, Potel, Clément, Jarzab, Anna, Kuster, Bernhard, Bartenschlager, Ralf, Boulant, Steeve, Beltrao, Pedro, Typas, Athanasios, Savitski, Mikhail M

“…The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a global threat to human health and has compromised economic stability. In addition to the…”
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Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer’s disease risk genes by Schwartzentruber, Jeremy, Cooper, Sarah, Liu, Jimmy Z., Barrio-Hernandez, Inigo, Bello, Erica, Kumasaka, Natsuhiko, Young, Adam M. H., Franklin, Robin J. M., Johnson, Toby, Estrada, Karol, Gaffney, Daniel J., Beltrao, Pedro, Bassett, Andrew

“…Genome-wide association studies have discovered numerous genomic loci associated with Alzheimer’s disease (AD); yet the causal genes and variants are…”
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UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites by Akimov, Vyacheslav, Barrio-Hernandez, Inigo, Hansen, Sten V. F., Hallenborg, Philip, Pedersen, Anna-Kathrine, Bekker-Jensen, Dorte B., Puglia, Michele, Christensen, Stine D. K., Vanselow, Jens T., Nielsen, Mogens M., Kratchmarova, Irina, Kelstrup, Christian D., Olsen, Jesper V., Blagoev, Blagoy

“…Ubiquitination is a post-translational modification (PTM) that is essential for balancing numerous physiological processes. To enable delineation of protein…”
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Differential evolution in 3′UTRs leads to specific gene expression in Staphylococcus by Menendez-Gil, Pilar, Caballero, Carlos J, Catalan-Moreno, Arancha, Irurzun, Naiara, Barrio-Hernandez, Inigo, Caldelari, Isabelle, Toledo-Arana, Alejandro

“…Abstract The evolution of gene expression regulation has contributed to species differentiation. The 3′ untranslated regions (3′UTRs) of mRNAs include…”
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Systematic identification of structure-specific protein–protein interactions by Holfeld, Aleš, Schuster, Dina, Sesterhenn, Fabian, Gillingham, Alison K, Stalder, Patrick, Haenseler, Walther, Barrio-Hernandez, Inigo, Ghosh, Dhiman, Vowles, Jane, Cowley, Sally A, Nagel, Luise, Khanppnavar, Basavraj, Serdiuk, Tetiana, Beltrao, Pedro, Korkhov, Volodymyr M, Munro, Sean, Riek, Roland, de Souza, Natalie, Picotti, Paola

“…The physical interactome of a protein can be altered upon perturbation, modulating cell physiology and contributing to disease. Identifying interactome…”
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Toward Understanding the Biochemical Determinants of Protein Degradation Rates by Correa Marrero, Miguel, Barrio-Hernandez, Inigo

“…Protein degradation is a key component of the regulation of gene expression and is at the center of several pathogenic processes. Proteins are regularly…”
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Cylindromatosis Tumor Suppressor Protein (CYLD) Deubiquitinase is Necessary for Proper Ubiquitination and Degradation of the Epidermal Growth Factor Receptor by Sanchez-Quiles, Virginia, Akimov, Vyacheslav, Osinalde, Nerea, Francavilla, Chiara, Puglia, Michele, Barrio-Hernandez, Inigo, Kratchmarova, Irina, Olsen, Jesper V., Blagoev, Blagoy

“…Cylindromatosis tumor suppressor protein (CYLD) is a deubiquitinase, best known as an essential negative regulator of the NFkB pathway. Previous studies have…”
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A human proteogenomic-cellular framework identifies KIF5A as a modulator of astrocyte process integrity with relevance to ALS by Szebényi, Kornélia, Barrio-Hernandez, Inigo, Gibbons, George M., Biasetti, Luca, Troakes, Claire, Beltrao, Pedro, Lakatos, András

“…Genome-wide association studies identified several disease-causing mutations in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS)…”
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Cellular Proteome Dynamics during Differentiation of Human Primary Myoblasts by Le Bihan, Marie-Catherine, Barrio-Hernandez, Inigo, Mortensen, Tenna Pavia, Henningsen, Jeanette, Jensen, Søren Skov, Bigot, Anne, Blagoev, Blagoy, Butler-Browne, Gillian, Kratchmarova, Irina

“…Muscle stem cells, or satellite cells, play an important role in the maintenance and repair of muscle tissue and have the capacity to proliferate and…”
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Network analysis of genome-wide association studies for drug target prioritisation by Barrio-Hernandez, Inigo, Beltrao, Pedro

“…Over the past decades, genome-wide association studies (GWAS) have led to a dramatic expansion of genetic variants implicated with human traits and diseases…”
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A pleiotropy map of cell biology covering 1,002 human traits

“…Interacting proteins commonly perform similar functions. A protein interaction network analysis of genes linked to 1,002 human traits identifies molecular…”
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Clustering predicted structures at the scale of the known protein universe by Barrio-Hernandez, Inigo, Yeo, Jingi, Jänes, Jürgen, Mirdita, Milot, Gilchrist, Cameron L. M., Wein, Tanita, Varadi, Mihaly, Velankar, Sameer, Beltrao, Pedro, Steinegger, Martin

“…Proteins are key to all cellular processes and their structure is important in understanding their function and evolution. Sequence-based predictions of…”
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Towards a structurally resolved human protein interaction network by Burke, David F., Bryant, Patrick, Barrio-Hernandez, Inigo, Memon, Danish, Pozzati, Gabriele, Shenoy, Aditi, Zhu, Wensi, Dunham, Alistair S., Albanese, Pascal, Keller, Andrew, Scheltema, Richard A., Bruce, James E., Leitner, Alexander, Kundrotas, Petras, Beltrao, Pedro, Elofsson, Arne

“…Cellular functions are governed by molecular machines that assemble through protein-protein interactions. Their atomic details are critical to studying their…”
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Network expansion of genetic associations defines a pleiotropy map of human cell biology by Barrio-Hernandez, Inigo, Schwartzentruber, Jeremy, Shrivastava, Anjali, del-Toro, Noemi, Gonzalez, Asier, Zhang, Qian, Mountjoy, Edward, Suveges, Daniel, Ochoa, David, Ghoussaini, Maya, Bradley, Glyn, Hermjakob, Henning, Orchard, Sandra, Dunham, Ian, Anderson, Carl A., Porras, Pablo, Beltrao, Pedro

“…Interacting proteins tend to have similar functions, influencing the same organismal traits. Interaction networks can be used to expand the list of candidate…”
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Magnitude of Ubiquitination Determines the Fate of Epidermal Growth Factor Receptor Upon Ligand Stimulation by Akimov, Vyacheslav, Fehling-Kaschek, Mirjam, Barrio-Hernandez, Inigo, Puglia, Michele, Bunkenborg, Jakob, Nielsen, Mogens M., Timmer, Jens, Dengjel, Jörn, Blagoev, Blagoy

“…[Display omitted] •Quantitative proteomics compares ubi-site changes on EGFR by four distinct ligands.•Identical sites on EGFR are ubiquitinated by all four…”
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Differential evolution in 3'UTRs leads to specific gene expression in Staphylococcus by Menendez-Gil, Pilar, Caballero, Carlos J, Catalan-Moreno, Arancha, Irurzun, Naiara, Barrio-Hernandez, Inigo, Caldelari, Isabelle, Toledo-Arana, Alejandro

“…The evolution of gene expression regulation has contributed to species differentiation. The 3' untranslated regions (3'UTRs) of mRNAs include regulatory…”
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Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow-derived stromal stem cells by Barrio-Hernandez, Inigo, Jafari, Abbas, Rigbolt, Kristoffer T G, Hallenborg, Philip, Sanchez-Quiles, Virginia, Skovrind, Ida, Akimov, Vyacheslav, Kratchmarova, Irina, Dengjel, Joern, Kassem, Moustapha, Blagoev, Blagoy

“…Bone marrow-derived mesenchymal stem cells (MSCs) differentiate into osteoblasts upon stimulation by signals present in their niche. Because the global…”
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The effects of pathogenic and likely pathogenic variants for inherited hemostasis disorders in 140 214 UK Biobank participants by Stefanucci, Luca, Collins, Janine, Sims, Matthew C., Barrio-Hernandez, Inigo, Sun, Luanluan, Burren, Oliver S., Perfetto, Livia, Bender, Isobel, Callahan, Tiffany J., Fleming, Kathryn, Guerrero, Jose A., Hermjakob, Henning, Martin, Maria J., Stephenson, James, Paneerselvam, Kalpana, Petrovski, Slavé, Porras, Pablo, Robinson, Peter N., Wang, Quanli, Watkins, Xavier, Frontini, Mattia, Laskowski, Roman A., Beltrao, Pedro, Di Angelantonio, Emanuele, Gomez, Keith, Laffan, Mike, Ouwehand, Willem H., Mumford, Andrew D., Freson, Kathleen, Carss, Keren, Downes, Kate, Gleadall, Nick, Megy, Karyn, Bruford, Elspeth, Vuckovic, Dragana

“…•Rare variants causal of recessive hemostasis disorders have clinical consequences in carriers.•Common variants modify these consequences and are one of the…”
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StUbEx PLUSA Modified Stable Tagged Ubiquitin Exchange System for Peptide Level Purification and In-Depth Mapping of Ubiquitination Sites by Akimov, Vyacheslav, Olsen, Louise C. B, Hansen, Sten V. F, Barrio-Hernandez, Inigo, Puglia, Michele, Jensen, Søren S, Solov’yov, Ilia A, Kratchmarova, Irina, Blagoev, Blagoy

“…Modulation of protein activities by reversible post-translational modifications (PTMs) is a major molecular mechanism involved in the control of virtually all…”
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