Search Results - "Barrio, J.R."

In vitro detection of ( S)-naproxen and ibuprofen binding to plaques in the Alzheimer’s brain using the positron emission tomography molecular imaging probe 2-(1-{6-[(2-[ 18F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile by Agdeppa, E.D, Kepe, V, Petri, A, Satyamurthy, N, Liu, J, Huang, S.-C, Small, G.W, Cole, G.M, Barrio, J.R

“…Epidemiological studies have suggested that the chronic use of non-steroidal anti-inflammatory drugs (NSAIDs) reduces the relative risk of Alzheimer’s disease…”
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Imaging Transgene Expression with Radionuclide Imaging Technologies by Gambhir, S.S., Herschman, H.R., Cherry, S.R., Barrio, J.R., Satyamurthy, N., Toyokuni, T., Phelps, M.E, Larson, S.M., Balatoni, J., Finn, R., Sadelain, M., Tjuvajev, J., Blasbergt, R.

“…A variety of imaging technologies are being investigated as tools for studying gene expression in living subjects. Noninvasive, repetitive and quantitative…”
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Amyloid and tau imaging, neuronal losses and function in mild cognitive impairment by Barrio, J.R., Kepe, V., Satyamurthy, N., Huang, S.C., Small, G.

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MRI Monitoring of Anti-Alzheimer Therapy Amyloid-Related Imaging Abnormalities: Due Diligence or Overkill? by Høilund-Carlsen, P F, Alavi, A, Perry, G, Barrio, J R

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Letter to the Editor: First Experiences with Amyloid-Related Imaging Abnormalities - Yet without Imaging that Can Rule Out Cerebral Injury or Monitor Efficacy of Recommended Management by Høilund-Carlsen, P F, Perry, G, Alavi, A, Barrio, J R

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FDDNP binding using MR derived cortical surface maps by Protas, H.D., Huang, S.-C., Kepe, V., Hayashi, K., Klunder, A., Braskie, M.N., Ercoli, L., Bookheimer, S., Thompson, P.M., Small, G.W., Barrio, J.R.

“…To assess quantitatively the cortical pattern profile of regional FDDNP binding to beta-amyloid and neurofibrillary tangles on MR derived cortical maps, FDDNP…”
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1,1-Dicyano-2-[6-(dimethylamino)naphthalen-2-yl]propene (DDNP):  A Solvent Polarity and Viscosity Sensitive Fluorophore for Fluorescence Microscopy by Jacobson, A, Petric, A, Hogenkamp, D, Sinur, A, Barrio, J. R

“…1,1-Dicyano-2-[6-(dimethylamino)naphthalen-2-yl]propene (II, DDNP) has been synthesized as a fluorescent dye whose intramolecular rotational relaxation is…”
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Assays for noninvasive imaging of reporter gene expression by Gambhir, S.S, Barrio, J.R, Herschman, H.R, Phelps, M.E

“…Repeated, noninvasive imaging of reporter gene expression is emerging as a valuable tool for monitoring the expression of genes in animals and humans…”
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Imaging gene expression: Principles and assays by Gambhir, S.S, Barrio, J.R, Herschman, H.R, Phelps, M.E

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An automated high pressure reaction vessel for routine preparation of short-lived radiopharmaceuticals by Ropchan, J R, Ricci, A R, Low, G C, Phelps, M E, Barrio, J R

“…A remote, automated high-pressure/temperature system for preparation of radiopharmaceuticals is described. The system was routinely employed in our…”
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Novel observations with FDOPA-PET imaging after early nigrostriatal damage by Yee, R.E., Irwin, I., Milonas, C., Stout, D.B., Huang, S-C., Shoghi-Jadid, K., Satyamurthy, N., Delanney, L.E., Togasaki, D.M., Farahani, K.F., Delfani, K., Janson, A.M., Phelps, M.E., Langston, J.W., Barrio, J.R.

“…Striatal 6‐[18F]fluoro‐L‐DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in…”
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Evaluation of two graphical approaches for regional analysis and parametric mapping of dynamic [18F]FDDNP PET studies by Koon-Pong Wong, Sung-Cheng Huang, Kepe, V., Small, G.W., Barrio, J.R.

“…Positron emission tomography (PET) with 2-(1-{6-[(2-[ 18 F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malo-nonitrile ([ 18 F]FDDNP) has been used for in…”
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Comparison of simplified methods for quantitative analysis of [18F]FDDNP PET data by Koon-Pong Wong, Kepe, V., Small, G.W., Satyamurthy, N., Barrio, J.R., Sung-Cheng Huang

“…Positron emission tomography (PET) with 2-(1-{6- [(2-[ 18 F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malo-nonitrile ([ 18 F]FDDNP) has been used for in…”
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Positron emission tomography (PET) imaging of AdCMVTk biodistributionin ortothopic hepatocellular carcinoma gene therapy by Barajas, Miguel, Narvaiza, Inigo, Penuelas, Ivan, Qian, Cheng, Marti, J., Boan, Jose, Font, Maria, Sangro, Bruno, Barrio, J.R., Gambhir, S.S., Richter, J.A., Prieto, Jesus

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Stereospecific approach to the synthesis of [18F]2-deoxy-2-fluoro-D-mannose by Luxen, A, Satyamurthy, N, Bida, G T, Barrio, J R

“…The reaction of methyl 4,6-O-benzylidene-3-O-benzyl-2-O-trifluoromethanesulfonyl-beta-D- glucopyranoside in acetonitrile at 75 degrees C for 30 min with…”
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Movement correction of [18F]FDDNP PET studies for brain amyloid imaging by Koon-Pong Wong, Wardak, M., Weber Shao, Zicong Zhou, Dahlbom, M., Smid, L., Truong, D., Kepe, V., Small, G.W., Barrio, J.R., Sung-Cheng Huang

“…2-(l-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naph- thyl}ethylidene)malononitrile ([ 18 F]FDDNP) PET studies for imaging neuronal concentration of beta-amyloid…”
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Elemental Fluorine to 8-Fluoropurines in One Step by Barrio, Jorge R, Namavari, Mohammad, Phelps, Michael E, Satyamurthy, Nagichettiar

“…An efficient regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine is described. The…”
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Nigrostriatal Reduction of Aromatic L‐Amino Acid Decarboxylase Activity in MPTP‐Treated Squirrel Monkeys: In Vivo and In Vitro Investigations by Yee, R.E., Huang, S.‐C., Stout, D.B., Irwin, I., Shoghi‐Jadid, K., Togaski, D.M., DeLanney, L.E., Langston, J.W., Satyamurthy, N., Farahani, K.F., Phelps, M.E., Barrio, J.R.

“…Aromatic L‐amino acid decarboxylase (AAAD) activity was examined in vivo with positron emission tomography (PET) using 6‐[18F]fluoro‐L‐DOPA (FDOPA) in squirrel…”
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Neuronal Membrane Transport and Compartmental Modeling of 6-[18F]Fluoro-L-DOPA (FDOPA) Striatal Kinetics by Yee, R.E., Huang, S-C., Barrio, J.R., Yee, E.

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A Comparison of FDOPA and FWIN Kinetics to Assess MPTP Lesioning in Squirrel Monkey by Stout, D.B., Huang, S-C, Yee, R., Satyamurthy, N., Irwin, I., De Lanney, L., Langston, W., Barrio, J.R.

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