Search Results - "Barrio, Alicia"

Recent developments in the design and synthesis of hybrid molecules based on aminoquinoline ring and their antiplasmodial evaluation by KOUZNETSOV, Vladimir V, GOMEZ-BARRIO, Alicia

“…A short history of hybrid molecules based on aminoquinolines gave interesting and important information useful for organic and medicinal chemistry, which are…”
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Synthesis and Biophysical and Biological Studies of N‑Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites by Nué-Martinez, J. Jonathan, Cisneros, David, Moreno-Blázquez, María del Valle, Fonseca-Berzal, Cristina, Manzano, José Ignacio, Kraeutler, Damien, Ungogo, Marzuq A., Aloraini, Maha A., Elati, Hamza A. A., Ibáñez-Escribano, Alexandra, Lagartera, Laura, Herraiz, Tomás, Gamarro, Francisco, de Koning, Harry P., Gómez-Barrio, Alicia, Dardonville, Christophe

“…The AT-rich mitochondrial DNA (kDNA) of trypanosomatid parasites is a target of DNA minor groove binders. We report the synthesis, antiprotozoal screening, and…”
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Contribution of the Diastolic Vortex Ring to Left Ventricular Filling by Martínez-Legazpi, Pablo, MEng, PhD, Bermejo, Javier, MD, PhD, Benito, Yolanda, DCS, DVM, Yotti, Raquel, MD, PhD, Pérez del Villar, Candelas, MD, González-Mansilla, Ana, MD, PhD, Barrio, Alicia, DCS, MBiol, Villacorta, Eduardo, MD, Sánchez, Pedro L., MD, PhD, Fernández-Avilés, Francisco, MD, PhD, del Álamo, Juan C., AeEng, PhD

“…Abstract Background Intraventricular fluid dynamics can be assessed clinically using imaging. The contribution of vortex structures to left ventricular (LV)…”
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Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis by Ibáñez-Escribano, Alexandra, Fonseca-Berzal, Cristina, Martínez-Montiel, Mónica, Álvarez-Márquez, Manuel, Gómez-Núñez, María, Lacueva-Arnedo, Manuel, Espinosa-Buitrago, Teresa, Martín-Pérez, Tania, Escario, José Antonio, Merino-Montiel, Penélope, Montiel-Smith, Sara, Gómez-Barrio, Alicia, López, Óscar, Fernández-Bolaños, José G

“…Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the…”
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5-Nitroindazole-based compounds: further studies for activity optimization as anti-Trypanosoma cruzi agents by Fonseca-Berzal, Cristina, Ibáñez-Escribano, Alexandra, de Castro, Sonia, Escario, José A., Gómez-Barrio, Alicia, Arán, Vicente J.

“…•In silico approaches point to both good oral bioavailability and non-risks for 5-nitroindazoles.•Neither nitro nor halogen groups induce toxicity in…”
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Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2‐Benzyl‐5‐nitroindazole‐Derived Amines by Fonseca‐Berzal, Cristina, Ibáñez‐Escribano, Alexandra, Vela, Nerea, Cumella, José, Nogal‐Ruiz, Juan José, Escario, José Antonio, da Silva, Patrícia Bernardino, Batista, Marcos Meuser, Soeiro, Maria de Nazaré C., Sifontes‐Rodríguez, Sergio, Meneses‐Marcel, Alfredo, Gómez‐Barrio, Alicia, Arán, Vicente J.

“…Three different series of new 5‐nitroindazole derivatives—1‐(ω‐aminoalkyl)‐2‐benzylindazolin‐3‐ones (series A; ten compounds),…”
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Experimental models in Chagas disease: a review of the methodologies applied for screening compounds against Trypanosoma cruzi by Fonseca-Berzal, Cristina, Arán, Vicente J., Escario, José A., Gómez-Barrio, Alicia

“…One of the main problems of Chagas disease (CD), the parasitic infection caused by Trypanosoma cruzi , is the lack of a completely satisfactory treatment,…”
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Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles by Ibáñez-Escribano, Alexandra, Reviriego, Felipe, Vela, Nerea, Fonseca-Berzal, Cristina, Nogal-Ruiz, Juan José, Arán, Vicente J., Escario, José Antonio, Gómez-Barrio, Alicia

“…[Display omitted] A series of 11 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles (2–12) has been prepared starting from 1-benzyl-5-nitroindazol-3-ol 13, and…”
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Development of novel benznidazole formulations: Physicochemical characterization and in vivo evaluation on parasitemia reduction in Chagas disease by Palmeiro-Roldán, Ricardo, Fonseca-Berzal, Cristina, Gómez-Barrio, Alicia, Arán, Vicente J., Escario, José A., Torrado-Durán, Susana, Torrado-Santiago, Santiago

“…[Display omitted] This work aims to develop novel benznidazole (BZN) solid dispersions (SD) to improve its solubility and bioavailability properties…”
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Intraventricular vortex properties in nonischemic dilated cardiomyopathy by Bermejo, Javier, Benito, Yolanda, Alhama, Marta, Yotti, Raquel, Martínez-Legazpi, Pablo, Del Villar, Candelas Pérez, Pérez-David, Esther, González-Mansilla, Ana, Santa-Marta, Cristina, Barrio, Alicia, Fernández-Avilés, Francisco, Del Álamo, Juan C

“…Vortices may have a role in optimizing the mechanical efficiency and blood mixing of the left ventricle (LV). We aimed to characterize the size, position,…”
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Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts by Anacleto-Santos, Jhony, Vega-Ávila, Elisa, Pacheco, Leticia, Lacueva-Arnedo, Manuel, Gómez-Barrio, Alicia, Ibáñez-Escribano, Alexandra, López-Pérez, Teresa de Jesús, Casarrubias-Tabarez, Brenda, Calzada, Fernando, López-Camacho, Perla Yolanda, Rivera-Fernández, Norma

“…is a fern documented in ethnobotanical records for its use in Mexican traditional medicine to treat gastric disorders and mouth ulcers. Consequently,…”
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Antichagasic and trichomonacidal activity of 1-substituted 2-benzyl-5-nitroindazolin-3-ones and 3-alkoxy-2-benzyl-5-nitro-2H-indazoles by Fonseca-Berzal, Cristina, Ibáñez-Escribano, Alexandra, Reviriego, Felipe, Cumella, José, Morales, Paula, Jagerovic, Nadine, Nogal-Ruiz, Juan José, Escario, José Antonio, da Silva, Patricia Bernardino, Soeiro, Maria de Nazaré C., Gómez-Barrio, Alicia, Arán, Vicente J.

“…Two series of new 5-nitroindazole derivatives, 1-substituted 2-benzylindazolin-3-ones (6–29, series A) and 3-alkoxy-2-benzyl-2H-indazoles (30–37, series B),…”
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In vitro phenotypic screening of 7-chloro-4-amino(oxy)quinoline derivatives as putative anti-Trypanosoma cruzi agents by Fonseca-Berzal, Cristina, Rojas Ruiz, Fernando A, Escario, José A, Kouznetsov, Vladimir V, Gómez-Barrio, Alicia

“…In this study, a series of 22 pre-synthesized 7-chloro-4-amino(oxy)quinoline derivatives was assayed in vitro as potential antichagasic agents. A primary…”
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Synthesis and antimalarial activity of new heterocyclic hybrids based on chloroquine and thiazolidinone scaffolds by Rojas Ruiz, Fernando A., García-Sánchez, Rory N., Estupiñan, Santiago Villabona, Gómez-Barrio, Alicia, Torres Amado, Diego F., Pérez-Solórzano, Berta Martín, Nogal-Ruiz, Juan J., Martínez-Fernández, Antonio R., Kouznetsov, Vladimir V.

“…A series of new 21 chloroquine molecules 1–4, 8–24 were synthesized and screened for their antimalarial activity against chloroquine (CQ)-sensitive 3D7 and…”
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Synthesis and characterization of a pyridine-2-thiol N-oxide gold(I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. insight into its mechanism of action by Vieites, Marisol, Smircich, Pablo, Guggeri, Lucía, Marchán, Edgar, Gómez-Barrio, Alicia, Navarro, Maribel, Garat, Beatriz, Gambino, Dinorah

“…In the search for new therapeutic tools against parasitic diseases caused by the Kinetoplastids Leishmania spp. and Trypanosoma cruzi, a novel gold(I)…”
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Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug by Vega, María Celeste, Rolón, Miriam, Montero-Torres, Alina, Fonseca-Berzal, Cristina, Escario, José Antonio, Gómez-Barrio, Alicia, Gálvez, Jorge, Marrero-Ponce, Yovani, Arán, Vicente J.

“…Chagas disease chemotherapy, currently based on only two drugs, nifurtimox and benznidazole, is far from satisfactory and therefore the development of new…”
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New Imidazole-Based Compounds Active Against Trypanosoma cruzi by Adeyemi, Oluyomi Stephen, Molina, María Teresa, Eseola, Abiodun Omokehinde, Fonseca-Berzal, Cristina, Gómez-Barrio, Alicia

“…Current drugs available for the treatment of Chagas disease are fraught with several challenges including severe toxicity and limited efficacy. These factors…”
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Sequestration of host-CD59 as potential immune evasion strategy of Trichomonas vaginalis by Ibáñez-Escribano, Alexandra, Nogal-Ruiz, Juan José, Pérez-Serrano, Jorge, Gómez-Barrio, Alicia, Escario, J. Antonio, Alderete, J.F.

“…•No sequence homology in Trichomonas vaginalis genome with CD59 human gene.•IFI detection of CD59 on T. vaginalis surface of flagellates recovered from…”
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Novel solid dispersions of benznidazole: Preparation, dissolution profile and biological evaluation as alternative antichagasic drug delivery system by Fonseca-Berzal, Cristina, Palmeiro-Roldán, Ricardo, Escario, José A., Torrado, Susana, Arán, Vicente J., Torrado-Santiago, Santiago, Gómez-Barrio, Alicia

“…•NaDC solid dispersions improved benznidazole IC50 on epimastigotes and amastigotes.•Solid dispersions with low ratios of surfactant did not result cytotoxic…”
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Bond-based bilinear indices for computational discovery of novel trypanosomicidal drug-like compounds through virtual screening by Castillo-Garit, Juan Alberto, del Toro-Cortés, Oremia, Vega, Maria C., Rolón, Miriam, Rojas de Arias, Antonieta, Casañola-Martin, Gerardo M., Escario, José A., Gómez-Barrio, Alicia, Marrero-Ponce, Yovani, Torrens, Francisco, Abad, Concepción

“…Two-dimensional bond-based bilinear indices and linear discriminant analysis are used in this report to perform a quantitative structure–activity relationship…”
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