Search Results - "Barrington, Robert"

CCR6-Positive γδ T Cells Provide Protection Against Intracorneal HSV-1 Infection by Fitzpatrick, Steffani, Lausch, Robert, Barrington, Robert A

“…γδ T cells offer an important early immune defense against many different pathogens, both bacterial and viral. Herein, we examined the capacity of γδ T cell…”
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γδ T17 Cells Regulate the Acute Antiviral Response of NK Cells in HSV-1–Infected Corneas by Rodenberg, Rachel R., Spadafora, Domenico, Fitzpatrick, Steffani, Daly, Grant, Lausch, Robert, Barrington, Robert A.

“…To determine whether γδ T cells regulate natural killer (NK) cells in the herpes simplex virus 1 (HSV-1)-infected cornea.PurposeTo determine whether γδ T cells…”
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Alveolar macrophage lipid burden correlates with clinical improvement in patients with pulmonary alveolar proteinosis by Lee, Elinor, Williams, Kevin J., McCarthy, Cormac, Bridges, James P., Redente, Elizabeth F., de Aguiar Vallim, Thomas Q., Barrington, Robert A., Wang, Tisha, Tarling, Elizabeth J.

“…Pulmonary alveolar proteinosis (PAP) is a life-threatening, rare lung syndrome for which there is no cure and no approved therapies. PAP is a disease of lipid…”
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Ablation of PDE4B protects from Pseudomonas aeruginosa‐induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia by Abou Saleh, Lina, Boyd, Abigail, Aragon, Ileana V., Koloteva, Anna, Spadafora, Domenico, Mneimneh, Wadad, Barrington, Robert A., Richter, Wito

“…Pseudomonas aeruginosa is a frequent cause of hospital‐acquired lung infections characterized by hyperinflammation, antibiotic resistance, and high…”
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A DNA Vaccine in Which the RSV-F Ectodomain Is Covalently Linked to the Burkholderia pseudomallei Antigens TssM and Hcp1 Augments the Humoral and Cytotoxic Response in Mice by Solodushko, Victor, Bitko, Vira, Barrington, Robert, Fouty, Brian

“…DNA vaccines have great potential to control infectious disease, particularly those caused by intracellular organisms. They are inexpensive to produce and can…”
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The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model by Hardy, Kierra S, Tuckey, Amanda N, Housley, Nicole A, Andrews, Joel, Patel, Mita, Al-Mehdi, Abu-Bakr, Barrington, Robert A, Cassel, Suzanne L, Sutterwala, Fayyaz S, Audia, Jonathon P

“…Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark of P…”
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Phosphatidylcholine as a metabolic cue for determining B cell fate and function by Brewer, Joseph W., Solodushko, Viktoriya, Aragon, Ileana, Barrington, Robert A.

“…•CCTα is required for antigen-specific, germinal center-derived antibody-secreting cells.•CCTα is required for antigen-specific, germinal center-derived memory…”
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Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia by Gwin, Meredith S, Alexeyev, Mikhail F, Geurts, Aron M, Lee, Ji Young, Zhou, Chun, Yang, Xi-Ming, Cohen, Michael V, Downey, James M, Barrington, Robert A, Spadafora, Domenico, Audia, Jonathon P, Frank, Dara W, Voth, Sarah, Pastukh, Viktoriya V, Bell, Jessica, Ayers, Linn, Tambe, Dhananjay T, Nelson, Amy R, Balczon, Ron, Lin, Mike T, Stevens, Troy

“…Pneumonia elicits the production of cytotoxic beta amyloid (Aβ) that contributes to end-organ dysfunction, yet the mechanism(s) linking infection to activation…”
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MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux by Barrington, Robert D., Needs, Paul W., Williamson, Gary, Kroon, Paul A.

“…MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor and has been widely used to demonstrate the role of Mrp2 in the cellular efflux of drugs,…”
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CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice by Smith, Christopher, Buhlmann, Janet E, Wang, Xiaogan, Bartlett, Amber, Lim, Bing, Barrington, Robert A

“…T cells undergo homeostatic expansion and acquire an activated phenotype in lymphopenic microenvironments. Restoration of normal lymphocyte numbers typically…”
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Peroxisome Proliferator-activated Receptor-γ Deficiency Exacerbates Fibrotic Response to Mycobacteria Peptide in Murine Sarcoidosis Model by Malur, Anagha, Mohan, Arjun, Barrington, Robert A, Leffler, Nancy, Malur, Amrita, Muller-Borer, Barbara, Murray, Gina, Kew, Kim, Zhou, Chuanzhen, Russell, Josh, Jones, Jacob L, Wingard, Christopher J, Barna, Barbara P, Thomassen, Mary Jane

“…We established a murine model of multiwall carbon nanotube (MWCNT)-elicited chronic granulomatous disease that bears similarities to human sarcoidosis…”
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Autoantibody-Mediated Pulmonary Alveolar Proteinosis in Rasgrp1-Deficient Mice by Ferretti, Andrew, Fortwendel, Jarrod R, Gebb, Sarah A, Barrington, Robert A

“…Pulmonary alveolar proteinosis (PAP) is a rare lung syndrome caused by the accumulation of surfactants in the alveoli. The most prevalent clinical form of PAP…”
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ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection by Hardy, Kierra S, Tuckey, Amanda N, Renema, Phoibe, Patel, Mita, Al-Mehdi, Abu-Bakr, Spadafora, Domenico, Schlumpf, Cody A, Barrington, Robert A, Alexeyev, Mikhail F, Stevens, Troy, Pittet, Jean-Francois, Wagener, Brant M, Simmons, Jon D, Alvarez, Diego F, Audia, Jonathon P

“…The Gram-negative, opportunistic pathogen utilizes a type III secretion system to inject exoenzyme effectors into a target host cell. Of the four best-studied…”
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The specialized unfolded protein response of B lymphocytes: ATF6α-independent development of antibody-secreting B cells by Aragon, Ileana V., Barrington, Robert A., Jackowski, Suzanne, Mori, Kazutoshi, Brewer, Joseph W.

“…► The UPR factor ATF6α is up-regulated and activated in LPS-stimulated B cells. ► ATF6α is not required for lymphocyte development. ► ATF6α is not required for…”
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Multiple checkpoint breach of B cell tolerance in Rasgrp1-deficient mice by Bartlett, Amber, Buhlmann, Janet E, Stone, James, Lim, Bing, Barrington, Robert A

“…Lymphopenic hosts offer propitious microenvironments for expansion of autoreactive B and T cells. Despite this, many lymphopenic hosts do not develop…”
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Long-Term Follow-Up of Gemogenovatucel-T (Vigil) Survival and Molecular Signals of Immune Response in Recurrent Ovarian Cancer by Rocconi, Rodney P., Stanbery, Laura, Madeira da Silva, Luciana, Barrington, Robert A., Aaron, Phylicia, Manning, Luisa, Horvath, Staci, Wallraven, Gladice, Bognar, Ernest, Walter, Adam, Nemunaitis, John

“…Aim: To determine the relationship between gene expression profile (GEP) and overall survival (OS) by NanoString following treatment with Vigil. Patients and…”
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Amyloid-β and caspase-1 are indicators of sepsis and organ injury by Tuckey, Amanda N, Brandon, Arcole, Eslaamizaad, Yasaman, Siddiqui, Waqar, Nawaz, Talha, Clarke, Christopher, Sutherland, Erica, Williams, Veronica, Spadafora, Domenico, Barrington, Robert A, Alvarez, Diego F, Mulekar, Madhuri S, Simmons, Jon D, Fouty, Brian W, Audia, Jonathon P

“…Sepsis is a life-threatening condition that results from a dysregulated host response to infection, leading to organ dysfunction. Despite the prevalence and…”
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A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis by Vukadin, Lana, Park, Bohye, Mohamed, Mostafa, Li, Huashi, Elkholy, Amr, Torrelli-Diljohn, Alex, Kim, Jung-Hyun, Jeong, Kyuho, Murphy, James M, Harvey, Caitlin A, Dunlap, Sophia, Gehrs, Leah, Lee, Hanna, Kim, Hyung-Gyoon, Sah, Jay Prakash, Lee, Seth N, Stanford, Denise, Barrington, Robert A, Foote, Jeremy B, Sorace, Anna G, Welner, Robert S, Hildreth, 3rd, Blake E, Lim, Ssang-Taek Steve, Ahn, Eun-Young Erin

“…Rare diseases are underrepresented in biomedical research, leading to insufficient awareness. Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome is a rare disease…”
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Uncoupling CD21 and CD19 of the B-cell coreceptor by Barrington, Robert A, Schneider, Thomas J, Pitcher, Lisa A, Mempel, Thorsten R, Ma, Minghe, Barteneva, Natasha S, Carroll, Michael C

“…Complement receptors (CRs) CD21 and CD35 form a coreceptor with CD19 and CD81 on murine B cells that when coligated with the B-cell receptor lowers the…”
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The role of complement in inflammation and adaptive immunity by Barrington, Robert, Zhang, Ming, Fischer, Michael, Carroll, Michael C.

“…Major advances in our understanding of the immunobiology of complement were made within the past 5 years primarily due to the development of gene‐targeting…”
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