Search Results - "Barringer, Kevin J."
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Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 7. 8-Arylethyldipyridodiazepinones as Potent Broad-Spectrum Inhibitors of Wild-Type and Mutant Enzymes
Published in Journal of medicinal chemistry (30-07-1998)“…Like other nonnucleoside inhibitors of HIV-1 reverse transcriptase, the dipyridodiazepinone nevirapine (Viramune, 1) selects for drug resistant variants of…”
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Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 8. 8-Aryloxymethyl- and 8-Arylthiomethyldipyridodiazepinones
Published in Journal of medicinal chemistry (30-07-1998)“…Nevirapine (I) is the first human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase (RT) inhibitor to reach regulatory approval. As a…”
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Isothermal, In Vitro Amplification of Nucleic Acids by a Multienzyme Reaction Modeled After Retroviral Replication
Published in Proceedings of the National Academy of Sciences - PNAS (01-03-1990)“…A target nucleic acid sequence can be replicated (amplified) exponentially in vitro under isothermal conditions by using three enzymatic activities essential…”
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Pichia pastoris as a Host System for Transformations
Published in Molecular and cellular biology (01-12-1985)“…We developed a methylotrophic yeast, Pichia pastoris, as a host for DNA transformations. The system is based on an auxotrophic mutant host of P. pastoris which…”
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Use of Self-Sustained Sequence Replication Amplification Reaction to Analyze and Detect Mutations in Zidovudine-Resistant Human Immunodeficiency Virus
Published in The Journal of infectious diseases (01-12-1991)“…Mutations at amino acid positions 67, 70, 215, and 219 in the human immunodeficiency virus type 1 (HIV-1) pol gene correlate with the emergence of resistance…”
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Functional Characterization of the Two Alcohol Oxidase Genes from the Yeast Pichia pastoris
Published in Molecular and cellular biology (01-03-1989)“…In Pichia pastoris, alcohol oxidase (AOX) is the first enzyme in the methanol utilization pathway and is encoded by two genes, AOX1 and AOX2. The DNA and…”
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Genomic clones encoding chicken myosin heavy-chain genes
Published in DNA (New York, N.Y.) (01-04-1987)“…A chicken genomic library was screened with a cDNA probe containing the 3' coding and noncoding portions of quail fast-twitch skeletal muscle myosin heavy…”
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