Favorable outcome of SARS-CoV-2 infection in pediatric hematology oncology patients during the second and third pandemic waves in Italy: a multicenter analysis from the Infectious Diseases Working Group of the Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)

Favorable outcome of SARS-CoV-2 infection in pediatric hematology oncology patients during the second and third pandemic waves in Italy: a multicenter analysis from the Infectious Diseases Working Group of the Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)

COVID-19 has a mild clinical course with low mortality rate in general pediatric population, while variable outcomes have been described in children with cancer. Infectious diseases working party of the AIEOP collected data on the clinical characteristics and outcomes of SARS-CoV-2 infections in ped...

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Published in:Annals of hematology Vol. 101; no. 8; pp. 1843 - 1851
Main Authors: Zama, Daniele, Baccelli, Francesco, Colombini, Antonella, Contino, Amalia, Calore, Elisabetta, Petris, Maria Grazia, Meneghello, Linda, Mercolini, Federico, Lo Vecchio, Andrea, Montalto, Shana, Meazza, Cristina, Barone, Angelica, Compagno, Francesca, Muggeo, Paola, Soncini, Elena, Brescia, Letizia, Giraldi, Eugenia, Giurici, Nagua, Mura, Rosa Maria, Cellini, Monica, Perruccio, Katia, Petroni, Valeria, La Spina, Milena, Ziino, Ottavio, Burnelli, Roberta, De Santis, Raffaella, Mascarin, Maurizio, Barretta, Valentina, Tridello, Gloria, Cesaro, Simone
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-08-2022
Springer Nature B.V
Subjects:
Chemotherapy
Coronaviruses
COVID-19
Hematology
Infections
Infectious diseases
Medicine
Medicine & Public Health
Oncology
Original
Original Article
Pandemics
Pediatrics
Severe acute respiratory syndrome coronavirus 2
Italy
SARS-COV- 2 infection
COVID-19
Pediatric oncology
Children
Outcome
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Summary:COVID-19 has a mild clinical course with low mortality rate in general pediatric population, while variable outcomes have been described in children with cancer. Infectious diseases working party of the AIEOP collected data on the clinical characteristics and outcomes of SARS-CoV-2 infections in pediatric oncology/hematology patients from April 2020 to May 2021, including the second and the third waves of the pandemic in Italy. Factors potentially associated with moderate, severe, or critical COVID-19 were analyzed. Of the 153 SARS-Cov2 infections recorded, 100 were asymptomatic and 53 symptomatic. The course of COVID-19 was mild in 41, moderate in 2, severe in 5, and critical in 5 children. A total of 40.5% of patients were hospitalized, ten requiring oxygen support and 5 admitted to the intensive care unit. Antibiotics and steroids were the most used therapies. No patient died due to SARS-CoV-2 infection. Infections occurring early (< 60 days) after the diagnosis of the underlying disease or after SCT were associated to moderate, severe, and critical disease compared to infections occurring late (> 60 days) or during maintenance therapy. In the patients on active chemotherapy, 59% withdrew the treatment for a median of 15 days. SARS-CoV-2 presented a favorable outcome in children with cancer in Italy during the pandemic. Modification of therapy represents a major concern in this population. Our findings suggest considering regular chemotherapy continuation, particularly in patients on maintenance therapy or infected late after the diagnosis.
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ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-022-04884-x