Search Results - "Barrett‐Jolley, R."

Inducible nitric oxide synthase inhibition by 1400W limits pain hypersensitivity in a neuropathic pain rat model by Staunton, C. A., Barrett‐Jolley, R., Djouhri, L., Thippeswamy, T.

“…New Findings What is the central question of this study? Can modulation of inducible NO synthase reduce pain behaviour and pro‐inflammatory cytokine signalling…”
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Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis by Sanchez, C, Bay-Jensen, A.-C, Pap, T, Dvir-Ginzberg, M, Quasnichka, H, Barrett-Jolley, R, Mobasheri, A, Henrotin, Y

“…Summary The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of proteins and glycoproteins, all of which are expressed by its…”
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TRPV4 and KCa ion channels functionally couple as osmosensors in the paraventricular nucleus by Feetham, C H, Nunn, N, Lewis, R, Dart, C, Barrett‐Jolley, R

“…Background and Purpose Transient receptor potential vanilloid type 4 (TRPV4) and calcium‐activated potassium channels (KCa) mediate osmosensing in many…”
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Activation of a chondrocyte volume-sensitive Cl− conductance prior to macroscopic cartilage lesion formation in the rabbit knee anterior cruciate ligament transection osteoarthritis model by Kumagai, Kosuke, Toyoda, Futoshi, Staunton, Caroline A, Maeda, Tsutomu, Okumura, Noriaki, Matsuura, Hiroshi, Matsusue, Yoshitaka, Imai, Shinji, Barrett-Jolley, Richard

“…Summary Objective The anterior cruciate ligament transection (ACLT) rabbit osteoarthritis (OA) model confers permanent knee instability and induces joint…”
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Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes by Lewis, R, Feetham, CH, Gentles, L, Penny, J, Tregilgas, L, Tohami, W, Mobasheri, A, Barrett‐Jolley, R

“…Background and Purpose Chondrocytes exist within cartilage and serve to maintain the extracellular matrix. It has been postulated that osteoarthritic (OA)…”
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Skeletal muscle transcriptomics identifies common pathways in nerve crush injury and ageing by Staunton, C A, Owen, E D, Hemmings, K, Vasilaki, A, McArdle, A, Barrett-Jolley, R, Jackson, M J

“…Motor unit remodelling involving repeated denervation and re-innervation occurs throughout life. The efficiency of this process declines with age contributing…”
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Ion Channels and Osteoarthritic Pain: Potential for Novel Analgesics by Staunton, C. A., Lewis, R., Barrett-Jolley, R.

“…Osteoarthritis (OA) is a debilitating chronic condition widely prevalent in ageing populations. Because the pathology of the disease includes cartilage erosion…”
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Nipecotic acid directly activates GABAA‐like ion channels by Barrett‐Jolley, R

“…The GABA‐related compound nipecotic acid is commonly used to inhibit GABA uptake. This report shows that nipecotic acid can also directly activate GABAA‐like…”
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Inhibition by α‐Tetrahydrodeoxycorticosterone (THDOC) of Pre‐Sympathetic Parvocellular Neurones in the Paraventricular Nucleus of Rat Hypothalamus by Womack, M D, Pyner, S, Barrett‐Jolley, R

“…Background and Purpose: α‐tetrahydrodeoxycorticosterone (THDOC) is an endogenous neuroactive steroid which increases in plasma and brain concentration during…”
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Rapid neuromodulation by cortisol in the rat paraventricular nucleus: an in vitro study by Zaki, Abu, Barrett‐Jolley, R

“…We have used a range of in vitro electrophysiological techniques to investigate the mechanism of rapid cortisol neuromodulation of parvocellular neurones in…”
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Evidence for functional ATP-sensitive (KATP ) potassium channels in human and equine articular chondrocytes by Mobasheri, A., B.Sc., A.R.C.S. (Hons.), M.Sc., D.Phil. (Oxon.), Gent, T.C., B.Sc. (Hons.), Nash, A.I., B.Sc. (Hons.), Womack, M.D., B.Sc. (Hons.), Ph.D. (Hons.), Moskaluk, C.A., M.D., Ph.D, Barrett-Jolley, R., B.Sc. (Hons.), D.Phil. (Oxon.)

“…Summary Objective Chondrocytes are highly sensitive to variations in extracellular glucose and oxygen levels in the extracellular matrix. As such, they must…”
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HyPer2 imaging reveals temporal and heterogeneous hydrogen peroxide changes in denervated and aged skeletal muscle fibers in vivo by Staunton, C. A., Owen, E. D., Pollock, N., Vasilaki, A., Barrett-Jolley, R., McArdle, A., Jackson, M. J.

“…To determine the role of denervation and motor unit turnover in the age-related increase in skeletal muscle oxidative stress, the hydrogen peroxide (H 2 O 2 )…”
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Quantitative analysis of voltage-gated potassium currents from primary equine (Equus caballus) and elephant (Loxodonta africana) articular chondrocytes by Mobasheri, A, Gent, T C, Womack, M D, Carter, S D, Clegg, P D, Barrett-Jolley, R

“…In this comparative study, we have established in vitro models of equine and elephant articular chondrocytes, examined their basic morphology, and…”
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Membrane channel gene expression in human costal and articular chondrocytes by Asmar, A., Barrett-Jolley, R., Werner, A., Kelly, R., Stacey, M.

“…Chondrocytes are the uniquely resident cells found in all types of cartilage and key to their function is the ability to respond to mechanical loads with…”
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Changes in ion channel expression in synovial fibroblasts in an in vitro model of osteoarthritis by Kumagai, K, O'Neill, N, Zouggari, S, Staunton, C.A, Bavan, S, Hadair, O, Sharif, U, Mobasheri, A, Barrett-Jolley, R

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Direct block of native and cloned (Kir2.1) inward rectifier K+ channels by chloroethylclonidine by Barrett‐Jolley, R, Dart, C, Standen, N B

“…We have investigated the inhibition of inwardly rectifying potassium channels by the α‐adrenergic agonist/antagonist chloroethylclonidine (CEC). We used two…”
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Altered ion channel function in an in vitro model of inflammatory arthritis by Lewis, R, Paddison, E.J, Wegg, M, Barrett-Jolley, R

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Analysis of single anion channel activity in chondrocytes in vitro by Kumagai, K, Toyoda, F, Maeda, T, Tanigawa, H, Mobasheri, A, Barrett-Jolley, R

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Ion channel expression and function in a chondrogenic progenitor cell line derived from osteoarthritic cartilage by Matta, C, Lewis, R, Barrett-Jolley, R, Labeed, F.H, Hughes, M.P, Uribe, M.C, May, S, Miosge, N, Mobsheri, A

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Inhibition of vascular K ATP channels by U‐37883A: a comparison with cardiac and skeletal muscle by Wellman, G C, Barrett‐Jolley, R, Köppel, H, Everitt, D, Quayle, J M

“…The aim of this study was to investigate the selectivity of the ATP‐sensitive potassium (K ATP ) channel inhibitor U‐37883A (4‐morpholinecarboximidine‐ N…”
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