Avian Models for Human Carcinogenesis—Recent Findings from Molecular and Clinical Research

Birds, especially the chick and hen, have been important biomedical research models for centuries due to the accessibility of the avian embryo and the early discovery of avian viruses. Comprehension of avian tumor virology was a milestone in basic cancer research, as was that of non-viral genesis, a...

Full description

Saved in:

Bibliographic Details
Published in:	Cells (Basel, Switzerland) Vol. 13; no. 21; p. 1797
Main Authors:	Niebora, Julia, Data, Krzysztof, Domagała, Dominika, Józkowiak, Małgorzata, Barrett, Saoirse, Norizadeh Abbariki, Tannaz, Bryja, Artur, Kulus, Magdalena, Woźniak, Sławomir, Ziemak, Hanna, Piotrowska-Kempisty, Hanna, Antosik, Paweł, Bukowska, Dorota, Mozdziak, Paul, Dzięgiel, Piotr, Kempisty, Bartosz
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 01-11-2024 MDPI
Subjects:	Angiogenesis Animal models B cells Cancer Cancer research Carcinogenesis Cell cycle Cell growth Chorioallantoic membrane Clinical trials Diagnosis Disease Drug resistance Epidemiology Genetic engineering Genomes hen model Infections Kaposi's sarcoma Kinases Lymphoma Medical research Metastases Metastasis MicroRNAs Molecular modelling Nobel prizes Oncology, Experimental oncoviruses Ovarian cancer Pathogenesis Proteins Review Rous, Francis Peyton Sarcoma Tumorigenesis Tumors Viral infections Viruses Wildfowl Poland
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Birds, especially the chick and hen, have been important biomedical research models for centuries due to the accessibility of the avian embryo and the early discovery of avian viruses. Comprehension of avian tumor virology was a milestone in basic cancer research, as was that of non-viral genesis, as it enabled the discovery of oncogenes. Furthermore, studies on avian viruses provided initial insights into Kaposi’s sarcoma and EBV-induced diseases. However, the role of birds in human carcinogenesis extends beyond the realm of virology research. Utilization of CAM, the chorioallantoic membrane, an easily accessible extraembryonic tissue with rich vasculature, has enabled studies on tumor-induced angiogenesis and metastasis and the efficient screening of potential anti-cancer compounds. Also, the chick embryo alone is an effective preclinical in vivo patient-derived xenograft model, which is important for the development of personalized therapies. Furthermore, adult birds may also closely resemble human oncogenesis, as evidenced by the laying hen, which is the only animal model of a spontaneous form of ovarian cancer. Avian models may create an interesting alternative compared with mammalian models, enabling the creation of a relatively cost-effective and easy-to-maintain platform to address key questions in cancer biology.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	2073-4409 2073-4409
DOI:	10.3390/cells13211797