Search Results - "Barrett, R W"

Randomized, double-blind, placebo-controlled study of XP13512/ GSK1838262 in patients with RLS by KUSHIDA, C. A, BECKER, P. M, ELLENBOGEN, A. L, CANAFAX, D. M, BARRETT, R. W

“…To assess the efficacy and tolerability of the nondopaminergic agent XP13512/GSK1838262 in adults with moderate to severe primary restless legs syndrome (RLS)…”
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Peptides on Phage: A Vast Library of Peptides for Identifying Ligands by Cwirla, Steven E., Peters, Elizabeth A., Barrett, Ronald W., Dower, William J.

“…We have constructed a vast library of peptides for finding compounds that bind to antibodies and other receptors. Millions of different hexapeptides were…”
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Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin by Wrighton, Nicholas C., Farrell, Francis X., Chang, Ray, Kashyap, Arun K., Barbone, Francis P., Mulcahy, Linda S., Johnson, Dana L., Barrett, Ronald W., Jolliffe, Linda K., Dower, William J.

“…Random phage display peptide libraries and affinity selective methods were used to isolate small peptides that bind to and activate the receptor for the…”
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The impact of dental Medicaid reform on dental care provider activity and market penetration of dental support organizations by Brickhouse, Tegwyn H., Dahman, Bassam A., Peters, Barrett W.R., Liu, Hangcheng, Kumar, Anita M.

“…Medicaid state dental programs have experienced changes related to provider practice settings with the increased growth of dental support organizations (DSOs)…”
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Generation and Screening of an Oligonucleotide-Encoded Synthetic Peptide Library by Needels, Michael C., Jones, David G., Tate, Emily H., Heinkel, Gregory L., Kochersperger, Lynn M., Dower, William J., Barrett, Ronald W., Gallop, Mark A.

“…We have prepared a library of ≈106different peptide sequences on small, spherical (10-μ m diameter) beads by the combinatorial chemical coupling of both L- and…”
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Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine by Cwirla, Steven E., Balasubramanian, Palaniappan, Duffin, David J., Wagstrom, Christopher R., Gates, Christian M., Singer, Sara C., Davis, Ann M., Tansik, Robert L., Mattheakis, Larry C., Boytos, Chris M., Schatz, Peter J., Baccanari, David P., Wrighton, Nicholas C., Barrett, Ronald W., Dower, William J.

“…Two families of small peptides that bind to the human thrombopoietin receptor and compete with the binding of the natural ligand thrombopoietin (TPO) were…”
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A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist by Schreuder, Herman, Tardif, Chantal, Trump-Kallmeyer, Susanne, Soffientini, Adolfo, Sarubbi, Edoardo, Akeson, Ann, Bowlin, Terry, Yanofsky, Stephen, Barrett, Ronald W

“…Inflammation, regardless of whether it is provoked by infection or by tissue damage, starts with the activation of macrophages which initiate a cascade of…”
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Increased potency of an erythropoietin peptide mimetic through covalent dimerization by Wrighton, Nicholas C, Balasubramanian, Palaniappan, Barbone, Francis P, Kashyap, Arun K, Farrell, Francis X, Jolliffe, Linda K, Barrett, Ronald W, Dower, William J

“…We have synthesized a chemically defined, dimeric form of an erythropoietin mimetic peptide (EMP) that displays 100-fold increased affinity for the…”
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High Affinity Type I Interleukin 1 Receptor Antagonists Discovered by Screening Recombinant Peptide Libraries by Yanofsky, Stephen D., Baldwin, David N., Butler, John H., Holden, Frank R., Jacobs, Jeffrey W., Balasubramanian, Palaniappan, Chinn, Jason P., Cwirla, Steven E., Peters-Bhatt, Elizabeth, Whitehorn, Erik A., Tate, Emily H., Akeson, Ann, Bowlin, Terry L., Dower, William J., Barrett, Ronald W.

“…Two families of peptides that specifically bind the extracellular domain of the human type I interleukin 1 (IL-1) receptor were identified from recombinant…”
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Ligand dissociation constants from competition binding assays: errors associated with ligand depletion by Goldstein, A, Barrett, R W

“…The dissociation constant of a ligand at a binding site (e.g., receptor, antibody) is often determined indirectly by competitive displacement of a radioligand…”
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Very low-dose computed tomography for planning and outcome measurement in knee replacement : The imperial knee protocol by HENCKEL, J, RICHARDS, R, LOZHKIN, K, HARRIS, S, RODRIGUEZ Y BAENA, F. M, BARRETT, A. R. W, COBB, J. P

“…Surgeons need to be able to measure angles and distances in three dimensions in the planning and assessment of knee replacement. Computed tomography (CT)…”
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Morphine and Other Opiates from Beef Brain and Adrenal by Goldstein, Avram, Barrett, Ronald W., James, Iain F., Lowney, Louise I., Weitz, Charles J., Knipmeyer, Laura L., Rapoport, Henry

“…We describe nonpeptide opioids found in extracts of beef hypothalamus and adrenal, which are recognized by antisera raised against morphine. Four have been…”
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Gabapentin enacarbil in restless legs syndrome: a phase 2b, 2-week, randomized, double-blind, placebo-controlled trial by Walters, Arthur S, Ondo, William G, Kushida, Clete A, Becker, Philip M, Ellenbogen, Aaron L, Canafax, Daniel M, Barrett, Ronald W

“…Assess the efficacy and tolerability of gabapentin enacarbil (GEn), a transported prodrug of gabapentin with improved gabapentin exposure, in adults with…”
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Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries by Gallop, Mark A, Barrett, Ronald W, Dower, William J, Fodor, Stephen P. A, Gordon, Eric M

“…Recent trends in the search for novel pharmacological agents have focused on the preparation of "chemical libraries" as potential sources of new leads for drug…”
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Selective enrichment and characterization of high affinity ligands from collections of random peptides on filamentous phage by Barrett, R W, Cwirla, S E, Ackerman, M S, Olson, A M, Peters, E A, Dower, W J

“…Large collections of random peptides can be expressed on the N-terminus of the pIII protein of filamentous phage and screened for binding to antibodies and…”
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A Generic Method for Expression and Use of "Tagged" Soluble Versions of Cell Surface Receptors by Whitehorn, Erik A, Tate, Emily, Yanofsky, Stephen D, Kochersperger, Lynn, Davis, Ann, Mortensen, Richard B, Yonkovich, Shirlee, Bell, Kim, Dower, William J, Barrett, Ronald W

“…A general method for expression, purification, immobilization, detection and radiolabeling of extracellular domains (ECD) of type I membrane proteins. The type…”
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Type-A cholecystokinin binding sites in cow brain: characterization using (-)-[3H]L364718 membrane binding assays by Barrett, R W, Steffey, M E, Wolfram, C A

“…(-)-[3H]L364718 membrane binding assays were employed to localize and characterize cholecystokinin (CCK)-A binding sites in rat and cow brain. Specific binding…”
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Distinct requirements for activation at CCK-A and CCK-B/gastrin receptors: studies with a C-terminal hydrazide analogue of cholecystokinin tetrapeptide (30-33) by Lin, C W, Holladay, M W, Barrett, R W, Wolfram, C A, Miller, T R, Witte, D, Kerwin, Jr, J F, Wagenaar, F, Nadzan, A M

“…We describe here the properties of tert-butyloxycarbonyl-Trp-Leu-Asp-Phe-NHNH2 (A-57696), a C-terminal hydrazide analogue of tert-butyloxycarbonyl-CCK4…”
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Type-A cholecystokinin receptors in CHP212 neuroblastoma cells: evidence for association with G protein and activation of phosphoinositide hydrolysis by Barrett, R W, Steffey, M E, Wolfram, C A

“…125I-Bolton Hunter-cholecystokinin octapeptide (BH-CCK8) and (-)-[3H]L-364718 membrane binding assays were used to identify and characterize cholecystokinin…”
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A chimeric D2 dopamine/m1 muscarinic receptor with D2 binding specificity mobilizes intracellular calcium in response to dopamine by ENGLAND, B. P, ACKERMAN, M. S, BARRETT, R. W

“…Using PCR methodology, a chimeric receptor cDNA was constructed in which the entire third cytoplasmic loop of the human D2 dopamine receptor was replaced by…”
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