Search Results - "Barrett, J."

Macrophages in Atherosclerosis Regression by Barrett, Tessa J.

“…Macrophages play a central role in the development of atherosclerotic cardiovascular disease (ASCVD), which encompasses coronary artery disease, peripheral…”
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Why are people still dying from TB in low-burden countries? by Barrett, J.

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The Immunoscore: Colon Cancer and Beyond by Angell, Helen K, Bruni, Daniela, Barrett, J Carl, Herbst, Ronald, Galon, Jérôme

“…Tumors evolve in close interaction with their microenvironment, which encompasses a continual tension between the developing tumor and the host immune system…”
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New IBD genetics: common pathways with other diseases by Lees, C W, Barrett, J C, Parkes, M, Satsangi, J

“…Complex disease genetics has been revolutionised in recent years by the advent of genome-wide association (GWA) studies. The chronic inflammatory bowel…”
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Deep drawing simulations using the finite element method embedding a multi-level crystal plasticity constitutive law: Experimental verification and sensitivity analysis by Barrett, Timothy J., Knezevic, Marko

“…This paper presents experimental verification of a multi-level simulation framework aimed at sheet metal forming analysis. Specifically, deep drawing of a…”
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VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research by Lai, Zhongwu, Markovets, Aleksandra, Ahdesmaki, Miika, Chapman, Brad, Hofmann, Oliver, McEwen, Robert, Johnson, Justin, Dougherty, Brian, Barrett, J Carl, Dry, Jonathan R

“…Accurate variant calling in next generation sequencing (NGS) is critical to understand cancer genomes better. Here we present VarDict, a novel and versatile…”
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On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient by Hermsen, Rutger, Deris, J. Barrett, Hwa, Terence

“…The rapid emergence of bacterial strains resistant to multiple antibiotics is posing a growing public health risk. The mechanisms underlying the rapid…”
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Haploview: analysis and visualization of LD and haplotype maps by Barrett, J. C., Fry, B., Maller, J., Daly, M. J.

“…Research over the last few years has revealed significant haplotype structure in the human genome. The characterization of these patterns, particularly in the…”
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Controlling Motion at the Nanoscale: Rise of the Molecular Machines by Abendroth, John M, Bushuyev, Oleksandr S, Weiss, Paul S, Barrett, Christopher J

“…As our understanding and control of intra- and intermolecular interactions evolve, ever more complex molecular systems are synthesized and assembled that are…”
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Self-Collected Anterior Nasal and Saliva Specimens versus Health Care Worker-Collected Nasopharyngeal Swabs for the Molecular Detection of SARS-CoV-2 by Hanson, K E, Barker, A P, Hillyard, D R, Gilmore, N, Barrett, J W, Orlandi, R R, Shakir, S M

“…We prospectively compared health care worker-collected nasopharyngeal swabs (NPS) to self-collected anterior nasal swabs (ANS) and straight saliva for the…”
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Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies by Higgins, J. P. T., Jackson, D, Barrett, J. K., Lu, G, Ades, A. E., White, I. R.

“…Meta‐analyses that simultaneously compare multiple treatments (usually referred to as network meta‐analyses or mixed treatment comparisons) are becoming…”
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Impact of a five-dimensional framework on R&D productivity at AstraZeneca by Morgan, Paul, Brown, Dean G., Lennard, Simon, Anderton, Mark J., Barrett, J. Carl, Eriksson, Ulf, Fidock, Mark, Hamrén, Bengt, Johnson, Anthony, March, Ruth E., Matcham, James, Mettetal, Jerome, Nicholls, David J., Platz, Stefan, Rees, Steve, Snowden, Michael A., Pangalos, Menelas N.

“…In 2011, AstraZeneca set out to improve its research and development (R&D) productivity by focusing decision-making using a framework with five technical…”
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Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial by Ledermann, Jonathan, Prof, Harter, Philipp, MD, Gourley, Charlie, Prof, Friedlander, Michael, Prof, Vergote, Ignace, Prof, Rustin, Gordon, Prof, Scott, Clare L, PhD, Meier, Werner, Prof, Shapira-Frommer, Ronnie, MD, Safra, Tamar, MD, Matei, Daniela, MD, Fielding, Anitra, MBChB, Spencer, Stuart, MSc, Dougherty, Brian, PhD, Orr, Maria, PhD, Hodgson, Darren, PhD, Barrett, J Carl, PhD, Matulonis, Ursula, MD

“…Summary Background Maintenance monotherapy with the PARP inhibitor olaparib significantly prolonged progression-free survival (PFS) versus placebo in patients…”
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Osimertinib As First-Line Treatment of EGFR Mutation-Positive Advanced Non-Small-Cell Lung Cancer by Ramalingam, Suresh S, Yang, James C-H, Lee, Chee Khoon, Kurata, Takayasu, Kim, Dong-Wan, John, Thomas, Nogami, Naoyuki, Ohe, Yuichiro, Mann, Helen, Rukazenkov, Yuri, Ghiorghiu, Serban, Stetson, Daniel, Markovets, Aleksandra, Barrett, J Carl, Thress, Kenneth S, Jänne, Pasi A

“…Purpose The AURA study ( ClinicalTrials.gov identifier: NCT01802632) included two cohorts of treatment-naïve patients to examine clinical activity and safety…”
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EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of leading technologies to support the clinical development of AZD9291 by Thress, Kenneth S, Brant, Roz, Carr, T. Hedley, Dearden, Simon, Jenkins, Suzanne, Brown, Helen, Hammett, Tracey, Cantarini, Mireille, Barrett, J. Carl

“…Highlights • Multiple platforms were compared for detection of EGFR mutations in plasma ctDNA. • Digital and traditional PCR assays were assessed using plasma…”
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Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M by Thress, Kenneth S, Paweletz, Cloud P, Felip, Enriqueta, Cho, Byoung Chul, Stetson, Daniel, Dougherty, Brian, Lai, Zhongwu, Markovets, Aleksandra, Vivancos, Ana, Kuang, Yanan, Ercan, Dalia, Matthews, Sarah E, Cantarini, Mireille, Barrett, J Carl, Jänne, Pasi A, Oxnard, Geoffrey R

“…A mutation conferring resistance to novel irreversible EGFR inhibitors is identified in cell-free plasma DNA from lung cancer patients. Here we studied…”
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Genomic Alterations in Langerhans Cell Histiocytosis by Rollins, Barrett J., MD, PhD

“…The discovery of recurrent somatic genomic alterations in Langerhans cell histiocytosis (LCH) has led to a new understanding of LCH as a clonal neoplastic…”
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MEROPS: the database of proteolytic enzymes, their substrates and inhibitors by Rawlings, Neil D., Barrett, Alan J., Bateman, Alex

“…Peptidases, their substrates and inhibitors are of great relevance to biology, medicine and biotechnology. The MEROPS database (http://merops.sanger.ac.uk)…”
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Mining drives extensive deforestation in the Brazilian Amazon by Sonter, Laura J., Herrera, Diego, Barrett, Damian J., Galford, Gillian L., Moran, Chris J., Soares-Filho, Britaldo S.

“…Mining poses significant and potentially underestimated risks to tropical forests worldwide. In Brazil’s Amazon, mining drives deforestation far beyond…”
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Photomobile Polymer Materials: Towards Light-Driven Plastic Motors by Yamada, Munenori, Kondo, Mizuho, Mamiya, Jun-ichi, Yu, Yanlei, Kinoshita, Motoi, Barrett, Christopher J, Ikeda, Tomiki

“…Can light drive a motor? Azobenzene‐containing liquid‐crystalline elastomers (LCEs) and their composite materials have the potential to show three‐dimensional…”
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