Search Results - "Barrett, C. J."

New IBD genetics: common pathways with other diseases by Lees, C W, Barrett, J C, Parkes, M, Satsangi, J

“…Complex disease genetics has been revolutionised in recent years by the advent of genome-wide association (GWA) studies. The chronic inflammatory bowel…”
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Haploview: analysis and visualization of LD and haplotype maps by Barrett, J. C., Fry, B., Maller, J., Daly, M. J.

“…Research over the last few years has revealed significant haplotype structure in the human genome. The characterization of these patterns, particularly in the…”
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Halogen-Bonded Cocrystals as Optical Materials: Next-Generation Control over Light–Matter Interactions by Christopherson, J.-C, Topić, F, Barrett, C. J, Friščić, T

“…This review summarizes the recent advances in utilizing halogen bond-driven cocrystal formation as a design element in the creation of optical or…”
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Cold photo-carving of halogen-bonded co-crystals of a dye and a volatile co-former using visible light by Borchers, T. H., Topić, F., Christopherson, J.-C., Bushuyev, O. S., Vainauskas, J., Titi, H. M., Friščić, T., Barrett, C. J.

“…The formation of co-crystals by the assembly of molecules with complementary molecular recognition functionalities is a popular strategy to design or improve a…”
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Rare-Variant Studies to Complement Genome-Wide Association Studies by Sazonovs, A, Barrett, J.C

“…Genome-wide association studies (GWASs) have revolutionized human disease genetics by discovering tens of thousands of associations between common variants and…”
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optiCall: a robust genotype-calling algorithm for rare, low-frequency and common variants by SHAH, T. S, LIU, J. Z, FLOYD, J. A. B, MORRIS, J. A, WIRTH, N, BARRETT, J. C, ANDERSON, C. A

“…Existing microarray genotype-calling algorithms adopt either SNP-by-SNP (SNP-wise) or sample-by-sample (sample-wise) approaches to calling. We have developed a…”
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Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms by Horikawa, Izumi, Barrett, J. Carl

“…Malignant transformation from mortal, normal cells to immortal, cancer cells is generally associated with activation of telomerase and subsequent telomere…”
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PD-L1 and immune infiltrates are differentially expressed in distinct subgroups of gastric cancer by Angell, H. K., Lee, J., Kim, K-M., Kim, K., Kim, S-T., Park, S. H., Kang, W. K., Sharpe, A., Ogden, J., Davenport, A., Hodgson, D. R., Barrett, J. C., Kilgour, E.

“…This study investigates the association of PD-L1 expression and immune cell infiltrates and their impact on clinical outcome, in addition to their overlap with…”
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Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity by Martin, K R, Barrett, J C

“…ROS are diverse and abundant in biological systems. While excessive ROS production clearly damages DNA, low levels of ROS affect cell signaling particularly at…”
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Fabrication of Microporous Thin Films from Polyelectrolyte Multilayers by Mendelsohn, J. D, Barrett, C. J, Chan, V. V, Pal, A. J, Mayes, A. M, Rubner, M. F

“…A simple process has been developed to create large area, highly uniform microporous thin films. Multilayers of weak polyelectrolytes were assembled onto…”
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Diet as a mechanism of coexistence between intertidal fish species of the U.K by Barrett, C. J, Johnson, M. L, Hull, S. L

“…While the syntopic nature of many intertidal fish communities suggest that resources such as food are shared, little has been done to assess the importance of…”
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High-resolution serum proteomic features for ovarian cancer detection by Conrads, T P, Fusaro, V A, Ross, S, Johann, D, Rajapakse, V, Hitt, B A, Steinberg, S M, Kohn, E C, Fishman, D A, Whitely, G, Barrett, J C, Liotta, L A, Petricoin, E F, Veenstra, T D

“…Serum proteomic pattern diagnostics is an emerging paradigm employing low-resolution mass spectrometry (MS) to generate a set of biomarker classifiers. In the…”
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Evidence-based laboratory medicine in oncology drug development: from biomarkers to diagnostics by Modur, Vijay, Hailman, Eric, Barrett, J C

“…The promise of targeted therapies in molecularly defined subsets of cancer has led to a transformation of the process of drug development in oncology. To…”
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Happy families? Insight into the coexistence between the curled octopus (Eledone cirrhosa) and common octopus (Octopus vulgaris) in waters around the UK by Barrett, C. J., Brazier, A.

“…This case study investigated the co‐occurrence of the curled octopus (Eledone cirrhosa) and common octopus (Octopus vulgaris), in waters around the United…”
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Using light to control physical properties of polymers and surfaces with azobenzene chromophores by El Halabieh, R. H., Mermut, Ozzy, Barrett, C. J.

“…Azobenzene chromophores can be switched between two geometric isomers using visible light. This photoisomerization is rapid, reversible, and of high quantum…”
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Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome by Kazuki, Y, Hoshiya, H, Kai, Y, Abe, S, Takiguchi, M, Osaki, M, Kawazoe, S, Katoh, M, Kanatsu-Shinohara, M, Inoue, K, Kajitani, N, Yoshino, T, Shirayoshi, Y, Ogura, A, Shinohara, T, Barrett, J C, Oshimura, M

“…Human artificial chromosomes (HACs) have several advantages as gene therapy vectors, including stable episomal maintenance that avoids insertional mutations…”
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PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics by RISINGER, J. I, HAYES, K, MAXWELL, G. L, CARNEY, M. E, DODGE, R. K, BARRETT, J. C, BERCHUCK, A

“…Mutation of the PTEN tumor suppressor gene is a frequent event in endometrial cancers. In other types of cancers, PTEN mutation has been associated with…”
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Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 Oncoprotein by Veldman, T, Horikawa, I, Barrett, J C, Schlegel, R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer by Cruz, C., Castroviejo-Bermejo, M., Gutiérrez-Enríquez, S., Llop-Guevara, A., Ibrahim, Y.H., Gris-Oliver, A., Bonache, S., Morancho, B., Bruna, A., Rueda, O.M., Lai, Z., Polanska, U.M., Jones, G.N., Kristel, P., de Bustos, L., Guzman, M., Rodríguez, O., Grueso, J., Montalban, G., Caratú, G., Mancuso, F., Fasani, R., Jiménez, J., Howat, W.J., Dougherty, B., Vivancos, A., Nuciforo, P., Serres-Créixams, X., Rubio, I.T., Oaknin, A., Cadogan, E., Barrett, J.C., Caldas, C., Baselga, J., Saura, C., Cortés, J., Arribas, J., Jonkers, J., Díez, O., O’Connor, M.J., Balmaña, J., Serra, V.

“…BRCA1 and BRCA2 (BRCA1/2)-deficient tumors display impaired homologous recombination repair (HRR) and enhanced sensitivity to DNA damaging agents or to…”
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Guidelines for investigating causality of sequence variants in human disease by MacArthur, D. G., Manolio, T. A., Dimmock, D. P., Rehm, H. L., Shendure, J., Abecasis, G. R., Adams, D. R., Altman, R. B., Antonarakis, S. E., Ashley, E. A., Barrett, J. C., Biesecker, L. G., Conrad, D. F., Cooper, G. M., Cox, N. J., Daly, M. J., Gerstein, M. B., Goldstein, D. B., Hirschhorn, J. N., Leal, S. M., Pennacchio, L. A., Stamatoyannopoulos, J. A., Sunyaev, S. R., Valle, D., Voight, B. F., Winckler, W., Gunter, C.

“…Acceleration in discovery of rare genetic variants possibly linked with disease may mean an increased risk of false-positive reports of causality; this…”
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