Search Results - "Barrett, Alexander"

A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma by Barnes, J. Matthew, Kaushik, Shelly, Bainer, Russell O., Sa, Jason K., Woods, Elliot C., Kai, FuiBoon, Przybyla, Laralynne, Lee, Mijeong, Lee, Hye Won, Tung, Jason C., Maller, Ori, Barrett, Alexander S., Lu, Kan V., Lakins, Jonathon N., Hansen, Kirk C., Obernier, Kirsten, Alvarez-Buylla, Arturo, Bergers, Gabriele, Phillips, Joanna J., Nam, Do-Hyun, Bertozzi, Carolyn R., Weaver, Valerie M.

“…Glioblastoma multiforme (GBMs) are recurrent lethal brain tumours. Recurrent GBMs often exhibit mesenchymal, stem-like phenotypes that could explain their…”
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Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression by Maller, Ori, Drain, Allison P., Barrett, Alexander S., Borgquist, Signe, Ruffell, Brian, Zakharevich, Igor, Pham, Thanh T., Gruosso, Tina, Kuasne, Hellen, Lakins, Johnathon N., Acerbi, Irene, Barnes, J. Matthew, Nemkov, Travis, Chauhan, Aastha, Gruenberg, Jessica, Nasir, Aqsa, Bjarnadottir, Olof, Werb, Zena, Kabos, Peter, Chen, Yunn-Yi, Hwang, E. Shelley, Park, Morag, Coussens, Lisa M., Nelson, Andrew C., Hansen, Kirk C., Weaver, Valerie M.

“…Stromal stiffening accompanies malignancy, compromises treatment and promotes tumour aggression. Clarifying the molecular nature and the factors that regulate…”
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Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217 by Northey, Jason J, Barrett, Alexander S, Acerbi, Irene, Hayward, Mary-Kate, Talamantes, Stephanie, Dean, Ivory S, Mouw, Janna K, Ponik, Suzanne M, Lakins, Jonathon N, Huang, Po-Jui, Wu, Junmin, Shi, Quanming, Samson, Susan, Keely, Patricia J, Mukhtar, Rita A, Liphardt, Jan T, Shepherd, John A, Hwang, E Shelley, Chen, Yunn-Yi, Hansen, Kirk C, Littlepage, Laurie E, Weaver, Valerie M

“…Women with dense breasts have an increased lifetime risk of malignancy that has been attributed to a higher epithelial density. Quantitative proteomics,…”
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The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation by Zhou, Jiechao, Chuang, Yang ‘an, Redding-Ochoa, Javier, Zhang, Rongzhen, Platero, Alexander J., Barrett, Alexander H., Troncoso, Juan C., Worley, Paul F., Zhang, Wenchi

“…Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RING-in-between-RING-type E3 ligase,…”
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Hydroxylamine Chemical Digestion for Insoluble Extracellular Matrix Characterization by Barrett, Alexander S, Wither, Matthew J, Hill, Ryan C, Dzieciatkowska, Monika, D’Alessandro, Angelo, Reisz, Julie A, Hansen, Kirk C

“…The extracellular matrix (ECM) is readily enriched by decellularizing tissues with nondenaturing detergents to solubilize and deplete the vast majority of…”
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Targeted matrisome analysis identifies thrombospondin-2 and tenascin-C in aligned collagen stroma from invasive breast carcinoma by Tomko, Lucas A., Hill, Ryan C., Barrett, Alexander, Szulczewski, Joseph M., Conklin, Matthew W., Eliceiri, Kevin W., Keely, Patricia J., Hansen, Kirk C., Ponik, Suzanne M.

“…Increasing evidence demonstrates an important role for the extracellular matrix (ECM) in breast cancer progression. Collagen type I, a core constituent of the…”
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Mammary collagen is under reproductive control with implications for breast cancer by Guo, Qiuchen, Sun, Duanchen, Barrett, Alexander S., Jindal, Sonali, Pennock, Nathan D., Conklin, Matthew W., Xia, Zheng, Mitchell, Elizabeth, Samatham, Ravikant, Mirza, Naomi, Jacques, Steven, Weinmann, Sheila, Borges, Virginia F., Hansen, Kirk C., Schedin, Pepper J.

“…•Mammary collagen gene expression, composition, and structure vary by reproductive state.•Peak collagen deposition occurs after weaning, during mammary gland…”
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Oxia Planum, Mars, classified using the NOAH-H deep-learning terrain classification system by Barrett, Alexander M., Wright, Jack, Favaro, Elena, Fawdon, Peter, Balme, Matthew R., Woods, Mark J., Karachalios, Spyros, Bohacek, Eleni, Sefton-Nash, Elliot, Joudrier, Luc

“…We present a map of Oxia Planum, Mars, the landing site for the ExoMars Rover. This shows surface texture and aeolian bedform distribution, classified using a…”
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Structural Insight into Recognition of Methylated Histone H3K4 by Set3 by Gatchalian, Jovylyn, Ali, Muzaffar, Andrews, Forest H., Zhang, Yi, Barrett, Alexander S., Kutateladze, Tatiana G.

“…The plant homeodomain (PHD) finger of Set3 binds methylated lysine 4 of histone H3 in vitro and in vivo; however, precise selectivity of this domain has not…”
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Mawrth Vallis, Mars, classified using the NOAH-H deep-learning terrain classification system by Barrett, Alexander M., Fawdon, Peter, Favaro, Elena A., Balme, Matthew R., Wright, Jack, Woods, Mark J., Karachalios, Spyros, Bohacek, Eleni, Gerdes, Levin, Sefton-Nash, Elliot, Joudrier, Luc

“…A deep learning (DL) terrain classification system, the Novelty and Anomaly Hunter - HiRISE (NOAH-H) was used to produce a terrain map of Mawrth Vallis, Mars…”
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Jezero crater, Mars: application of the deep learning NOAH-H terrain classification system by Wright, Jack, Barrett, Alexander M., Fawdon, Peter, Favaro, Elena A., Balme, Matthew R., Woods, Mark J., Karachalios, Spyros

“…We applied a deep learning terrain classification system, the 'Novelty or Anomaly Hunter - HiRISE' (NOAH-H), originally developed for the ExoMars landing sites…”
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New syngas/air ignition data at lower temperature and elevated pressure and comparison to current kinetics models by Petersen, Eric L., Kalitan, Danielle M., Barrett, Alexander B., Reehal, Shatra C., Mertens, John D., Beerer, David J., Hack, Richard L., McDonell, Vincent G.

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Targeting HER2/HER3 co‐mutations in metastatic breast cancer: Case reports of exceptional responders to trastuzumab and pertuzumab therapy by Blas, Page E., Rodriguez, Esther San Roman, Williams, Heather L., Levin, Maren K., Bell, Joshua S. K., Pierobon, Mariaelena, Barrett, Alexander S., Petricoin, Emanuel F., O'Shaughnessy, Joyce A.

“…Background Overexpression of HER2 plays an important role in cancer progression and is the target of multiple therapies in HER2‐positive breast cancer. Recent…”
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A Novel Correction for the Adjusted Box-Pierce Test by Danioko, Sidy, Zheng, Jianwei, Anderson, Kyle, Barrett, Alexander, Rakovski, Cyril S.

“…The classical Box-Pierce and Ljung-Box tests for auto-correlation of residuals possess severe deviations from nominal type I error rates. Previous studies have…”
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The high-resolution map of Oxia Planum, Mars; the landing site of the ExoMars Rosalind Franklin rover mission by Fawdon, Peter, Orgel, Csilla, Adeli, Solmaz, Balme, Matt, Calef, Fred J., Davis, Joel M., Frigeri, Alessandro, Grindrod, Peter, Hauber, Ernst, Le Deit, Laetitia, Loizeau, Damien, Nass, Andrea, Quantin-Nataf, Cathy, Sefton-Nash, Elliot, Thomas, Nick, Torres, Ines, Vago, Jorge L., Volat, Matthieu, De Witte, Sander, Altieri, Francesca, Apuzzo, Andrea, Aramendia, Julene, Arana, Gorka, Bahia, Rickbir Singh, Banham, Steven G., Barnes, Robert, Barrett, Alexander M., Benedix, Wolf-Stefan, Bhardwaj, Anshuman, Boazman, Sarah Jane, Bontognali, Tomaso R. R., Bridges, John, Bultel, Benjamin, Ciarletti, Valérie, De Sanctis, Maria Cristina, Dickeson, Zach, Favaro, Elena A., Ferrari, Marco, Foucher, Frédéric, Goetz, Walter, Haldemann, Albert F. C., Harrington, Elise, Kapatza, Angeliki, Koschny, Detlef, Krzesinska, Agata M., Le Gall, Alice, Lewis, Stephen R., Lim, Tanya, Madariaga, Juan Manuel, Man, Benjamin James, Mandon, Lucia, Mangold, Nicolas, Martin-Torres, Javier, McNeil, Joseph D., Molina, Antonio, Moral, Andoni G., Motaghian, Sara, Nikiforov, Sergei, Oudart, Nicolas, Pacifici, Andrea, Parkes Bowen, Adam, Plettemeier, Dirk, Poulakis, Pantelis, Putri, Alfiah Rizky Diana, Ruesch, Ottaviano, Sam, Lydia, Schröder, Christian, Statz, Christoph, Thomas, Rebecca, Tirsch, Daniela, Toth, Zsuzsanna, Turner, Stuart, Voelker, Martin, Werner, Stephanie C., Westall, Frances, Whiteside, Barry J., Williams, Adam, Williams, Rebecca M. E., Wright, Jack, Zorzano, Maria-Paz

“…This 1:30,000 scale geological map describes Oxia Planum, Mars, the landing site for theExoMars Rosalind Franklin rover mission. The map represents our current…”
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When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies by Reisz, Julie A, Barrett, Alexander S, Nemkov, Travis, Hansen, Kirk C, D'Alessandro, Angelo

“…Proteins have been historically regarded as 'nature's robots': Molecular machines that are essential to cellular/extracellular physical mechanical properties…”
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Fibroblast subtypes define a metastatic matrisome in breast cancer by Brechbuhl, Heather M, Barrett, Alexander S, Kopin, Etana, Hagen, Jaime C, Han, Amy L, Gillen, Austin E, Finlay-Schultz, Jessica, Cittelly, Diana M, Owens, Philip, Horwitz, Kathryn B, Sartorius, Carol A, Hansen, Kirk, Kabos, Peter

“…Small primary breast cancers can show surprisingly high potential for metastasis. Clinical decision-making for tumor aggressiveness, including molecular…”
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TAKING AIM AT FELONY POSSESSION by Barrett, Alexander C

“…The Supreme Court's 2008 decision in District of Columbia v. Heller announced, for the first time, that the Second Amendment to the U.S. Constitution secures…”
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Landscape of KRAS G12C , Associated Genomic Alterations, and Interrelation With Immuno-Oncology Biomarkers in KRAS -Mutated Cancers by Salem, Mohamed E, El-Refai, Sherif M, Sha, Wei, Puccini, Alberto, Grothey, Axel, George, Thomas J, Hwang, Jimmy J, O'Neil, Bert, Barrett, Alexander S, Kadakia, Kunal C, Musselwhite, Laura W, Raghavan, Derek, Van Cutsem, Eric, Tabernero, Josep, Tie, Jeanne

“…Promising single-agent activity from sotorasib and adagrasib in -mutant tumors has provided clinical evidence of effective KRAS signaling inhibition. However,…”
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Determination of the rate of H+O2+M→HO2+M (M=N2, Ar, H2O) from ignition of syngas at practical conditions by Mertens, John D., Kalitan, Danielle M., Barrett, Alexander B., Petersen, Eric L.

“…In H2 and H2/CO oxidation, the H+O2+M termination step is one of the most important reactions at elevated pressures. With the recent, increased interest in…”
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