Search Results - "Barrera‐Chimal, Jonatan"

Pathophysiologic mechanisms in diabetic kidney disease: A focus on current and future therapeutic targets by Barrera‐Chimal, Jonatan, Jaisser, Frédéric

“…Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease around the globe and is one of the main complications in patients with type 1 and…”
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Mineralocorticoid receptor antagonists in diabetic kidney disease — mechanistic and therapeutic effects by Barrera-Chimal, Jonatan, Lima-Posada, Ixchel, Bakris, George L., Jaisser, Frederic

“…Chronic kidney disease (CKD) is the leading complication in type 2 diabetes (T2D) and current therapies that limit CKD progression and the development of…”
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The mineralocorticoid receptor in chronic kidney disease by Barrera‐Chimal, Jonatan, Jaisser, Frédéric, Anders, Hans‐Joachim

“…Chronic kidney disease (CKD) is a major public health concern, affecting approximately 10% of the population worldwide. CKD of glomerular or tubular origin…”
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Vascular and inflammatory mineralocorticoid receptors in kidney disease by Barrera‐Chimal, Jonatan, Jaisser, Frederic

“…Mineralocorticoid receptor (MR) activation in the kidney can occur outside the aldosterone‐sensitive distal nephron in sites including the endothelium, smooth…”
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Short‐ and long‐term administration of the non‐steroidal mineralocorticoid receptor antagonist finerenone opposes metabolic syndrome‐related cardio‐renal dysfunction by Lachaux, Marianne, Barrera‐Chimal, Jonatan, Nicol, Lionel, Rémy‐Jouet, Isabelle, Renet, Sylvanie, Dumesnil, Anais, Wecker, Didier, Richard, Vincent, Kolkhof, Peter, Jaisser, Frederic, Ouvrard‐Pascaud, Antoine, Mulder, Paul

“…Aim To determine whether non‐steroidal mineralocorticoid receptor (MR) antagonists oppose metabolic syndrome‐related end‐organ, i.e. cardiac, damage. Materials…”
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Roles of Mineralocorticoid Receptors in Cardiovascular and Cardiorenal Diseases by Barrera-Chimal, Jonatan, Bonnard, Benjamin, Jaisser, Frederic

“…Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological effects, such as excessive extracellular matrix accumulation,…”
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Hsp72 is an early and sensitive biomarker to detect acute kidney injury by Barrera‐Chimal, Jonatan, Pérez‐Villalva, Rosalba, Cortés‐González, Cesar, Ojeda‐Cervantes, Marcos, Gamba, Gerardo, Morales‐Buenrostro, Luis E., Bobadilla, Norma A.

“…This study was designed to assess whether heat shock protein Hsp72 is an early and sensitive biomarker of acute kidney injury (AKI) as well as to monitor a…”
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The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling by Barrera-Chimal, Jonatan, Estrela, Gabriel R, Lechner, Sebastian M, Giraud, Sébastien, El Moghrabi, Soumaya, Kaaki, Shiem, Kolkhof, Peter, Hauet, Thierry, Jaisser, Frédéric

“…Acute kidney injury induced by ischemia/reperfusion is an independent risk factor for chronic kidney disease. Macrophage recruitment plays an essential role…”
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Differentiation between emerging non-steroidal and established steroidal mineralocorticoid receptor antagonists: head-to-head comparisons of pharmacological and clinical characteristics by Barrera-Chimal, Jonatan, Kolkhof, Peter, Lima-Posada, Ixchel, Joachim, Alexandre, Rossignol, Patrick, Jaisser, Frederic

“…Mineralocorticoid receptor (MR) antagonists (MRAs) provide cardiorenal protection. However steroidal MRAs might induce hyperkalemia and sex hormone-related…”
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Nonepithelial mineralocorticoid receptor activation as a determinant of kidney disease by Nakamura, Toshifumi, Girerd, Sophie, Jaisser, Frederic, Barrera-Chimal, Jonatan

“…Chronic kidney disease is a major global health challenge, and mineralocorticoid receptor (MR) signaling is thought to play a role in disease progression. The…”
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Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1 by Barrera-Chimal, Jonatan, André-Grégoire, Gwennan, Nguyen Dinh Cat, Aurelie, Lechner, Sebastian M, Cau, Jérôme, Prince, Sonia, Kolkhof, Peter, Loirand, Gervaise, Sauzeau, Vincent, Hauet, Thierry, Jaisser, Frédéric

“…AKI is a frequent complication in hospitalized patients. Unfortunately, there is no effective pharmacologic approach for treating or preventing AKI. In…”
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AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease by Rodríguez-Romo, Roxana, Benítez, Kenia, Barrera-Chimal, Jonatan, Pérez-Villalva, Rosalba, Gómez, Arturo, Aguilar-León, Diana, Rangel-Santiago, Jesús F, Huerta, Sara, Gamba, Gerardo, Uribe, Norma, Bobadilla, Norma A

“…Despite clinical recovery of patients from an episode of acute kidney injury (AKI), progression to chronic kidney disease (CKD) is possible on long-term…”
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Delayed spironolactone administration prevents the transition from acute kidney injury to chronic kidney disease through improving renal inflammation by Barrera-Chimal, Jonatan, Rocha, Leslie, Amador-Martínez, Isabel, Pérez-Villalva, Rosalba, González, Rafael, Cortés-González, Cesar, Uribe, Norma, Ramírez, Victoria, Berman, Nathan, Gamba, Gerardo, Bobadilla, Norma A

“…Acute kidney injury (AKI) is not as harmless as previously thought since it may lead to chronic kidney disease (CKD). Because most of the time ischemic AKI…”
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PPAR-α Deletion Attenuates Cisplatin Nephrotoxicity by Modulating Renal Organic Transporters MATE-1 and OCT-2 by Freitas-Lima, Leandro Ceotto, Budu, Alexandre, Arruda, Adriano Cleis, Perilhão, Mauro Sérgio, Barrera-Chimal, Jonatan, Araujo, Ronaldo Carvalho, Estrela, Gabriel Rufino

“…Cisplatin is a chemotherapy drug widely used in the treatment of solid tumors. However, nephrotoxicity has been reported in about one-third of patients…”
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Spironolactone prevents chronic kidney disease caused by ischemic acute kidney injury by Barrera-Chimal, Jonatan, Pérez-Villalva, Rosalba, Rodríguez-Romo, Roxana, Reyna, Juan, Uribe, Norma, Gamba, Gerardo, Bobadilla, Norma A

“…Acute kidney injury (AKI) has been recognized as a risk factor for the development of chronic kidney disease (CKD). Aldosterone has a critical role in…”
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Editorial: Kidney and Distant Organ Crosstalk in Health and Disease by López-Andrés, Natalia, Jaisser, Frederic, Barrera-Chimal, Jonatan

“…Kidney disease is a health condition affecting a high number of patients with an estimated worldwide prevalence of 10% (Jager et al., 2019). Kidney dysfunction…”
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Early inflammatory changes and CC chemokine ligand‐8 upregulation in the heart contribute to uremic cardiomyopathy by Amador‐Martínez, Isabel, García‐Ballhaus, Johannes, Buelna‐Chontal, Mabel, Cortés‐González, César, Massó, Felipe, Jaisser, Frédéric, Barrera‐Chimal, Jonatan

“…Uremic cardiomyopathy is a common complication in chronic kidney disease (CKD) patients, accounting for a high mortality rate. Several mechanisms have been…”
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The Calcium-Sensing Receptor Increases Activity of the Renal NCC through the WNK4-SPAK Pathway by Bazúa-Valenti, Silvana, Rojas-Vega, Lorena, Castañeda-Bueno, María, Barrera-Chimal, Jonatan, Bautista, Rocío, Cervantes-Pérez, Luz G, Vázquez, Norma, Plata, Consuelo, Murillo-de-Ozores, Adrián R, González-Mariscal, Lorenza, Ellison, David H, Riccardi, Daniela, Bobadilla, Norma A, Gamba, Gerardo

“…Hypercalciuria can result from activation of the basolateral calcium-sensing receptor (CaSR), which in the thick ascending limb of Henle's loop controls Ca…”
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The Absence of Endothelial Sodium Channel α (αENaC) Reduces Renal Ischemia/Reperfusion Injury by Tarjus, Antoine, González-Rivas, Cecilia, Amador-Martínez, Isabel, Bonnard, Benjamin, López-Marure, Rebeca, Jaisser, Frédéric, Barrera-Chimal, Jonatan

“…The epithelial sodium channel (ENaC) has a key role in modulating endothelial cell stiffness and this in turn regulates nitric oxide (NO) synthesis. The…”
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Oxidized Albumin as a Mediator of Kidney Disease by Figueroa, Stefanny M, Araos, Patricio, Reyes, Javier, Gravez, Basile, Barrera-Chimal, Jonatan, Amador, Cristián A

“…Renal diseases are a global health concern, and nearly 24% of kidney disease patients are overweight or obese. Particularly, increased body mass index has been…”
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