Search Results - "Barreca, Marilia"

HSV-1 Glycoprotein D and Its Surface Receptors: Evaluation of Protein-Protein Interaction and Targeting by Triazole-Based Compounds through In Silico Approaches by Bivacqua, Roberta, Romeo, Isabella, Barreca, Marilia, Barraja, Paola, Alcaro, Stefano, Montalbano, Alessandra

“…Protein-protein interactions (PPI) represent attractive targets for drug design. Thus, aiming at a deeper insight into the HSV-1 envelope glycoprotein D (gD),…”
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Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes by Barreca, Marilia, Spanò, Virginia, Montalbano, Alessandra, Cueto, Mercedes, Díaz Marrero, Ana R, Deniz, Irem, Erdoğan, Ayşegül, Lukić Bilela, Lada, Moulin, Corentin, Taffin-de-Givenchy, Elisabeth, Spriano, Filippo, Perale, Giuseppe, Mehiri, Mohamed, Rotter, Ana, P Thomas, Olivier, Barraja, Paola, Gaudêncio, Susana P, Bertoni, Francesco

“…The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique…”
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Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein by Spanò, Virginia, Barreca, Marilia, Cilibrasi, Vincenzo, Genovese, Michele, Renda, Mario, Montalbano, Alessandra, Galietta, Luis Juan Vicente, Barraja, Paola

“…Cystic fibrosis (CF) is a genetic disease caused by mutations that impair the function of the CFTR chloride channel. The most frequent mutation, F508del,…”
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Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors by Spanò, Virginia, Barreca, Marilia, Rocca, Roberta, Bortolozzi, Roberta, Bai, Ruoli, Carbone, Anna, Raimondi, Maria Valeria, Piccionello, Antonio Palumbo, Montalbano, Alessandra, Alcaro, Stefano, Hamel, Ernest, Viola, Giampietro, Barraja, Paola

“…A series of [1,3]thiazolo[4,5-e]isoindoles has been synthesized through a versatile and high yielding multistep sequence. Evaluation of the antiproliferative…”
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The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma by Grillone, Katia, Riillo, Caterina, Rocca, Roberta, Ascrizzi, Serena, Spanò, Virginia, Scionti, Francesca, Polerà, Nicoletta, Maruca, Annalisa, Barreca, Marilia, Juli, Giada, Arbitrio, Mariamena, Di Martino, Maria Teresa, Caracciolo, Daniele, Tagliaferri, Pierosandro, Alcaro, Stefano, Montalbano, Alessandra, Barraja, Paola, Tassone, Pierfrancesco

“…Microtubule-targeting agents (MTAs) are effective drugs for cancer treatment. A novel diaryl [1,2]oxazole class of compounds binding the colchicine site was…”
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Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel by Renda, Mario, Barreca, Marilia, Borrelli, Anna, Spanò, Virginia, Montalbano, Alessandra, Raimondi, Maria Valeria, Bivacqua, Roberta, Musante, Ilaria, Scudieri, Paolo, Guidone, Daniela, Buccirossi, Martina, Genovese, Michele, Venturini, Arianna, Bandiera, Tiziano, Barraja, Paola, Galietta, Luis J. V.

“…F508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular…”
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Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity by Barreca, Marilia, Spanò, Virginia, Raimondi, Maria Valeria, Tarantelli, Chiara, Spriano, Filippo, Bertoni, Francesco, Barraja, Paola, Montalbano, Alessandra

“…Because of its wide spectrum of targets and biological activities, the oxazole ring is a valuable heterocyclic scaffold in the design of new therapeutic agents…”
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Editorial: Emerging heterocycles as bioactive compounds by Li Petri, Giovanna, Holl, Ralph, Spanò, Virginia, Barreca, Marilia, Sardo, Ignazio, Raimondi, Maria Valeria

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Antibody-drug conjugates for lymphoma patients: preclinical and clinical evidences by Barreca, Marilia, Lang, Noémie, Tarantelli, Chiara, Spriano, Filippo, Barraja, Paola, Bertoni, Francesco

“…Antibody-drug conjugates (ADCs) are a recent, revolutionary approach for malignancies treatment, designed to provide superior efficacy and specific targeting…”
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Pharmacologic screen identifies active combinations with BET inhibitors and LRRK2 as a novel putative target in lymphoma by Spriano, Filippo, Sartori, Giulio, Tarantelli, Chiara, Barreca, Marilia, Golino, Gaetanina, Rinaldi, Andrea, Napoli, Sara, Mascia, Michele, Scalise, Lorenzo, Arribas, Alberto J., Cascione, Luciano, Zucca, Emanuele, Stathis, Anastasios, Gaudio, Eugenio, Bertoni, Francesco

“…Inhibitors of the Bromo‐ and Extra‐Terminal domain (BET) family proteins have strong preclinical antitumor activity in multiple tumor models, including…”
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An overview on anti-tubulin agents for the treatment of lymphoma patients by Barreca, Marilia, Stathis, Anastasios, Barraja, Paola, Bertoni, Francesco

“…Anti-tubulin agents constitute a large class of compounds with broad activity both in solid tumors and hematologic malignancies, due to the interference with…”
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New strategies to hit hematological cancers by Barreca, Marilia, Bertoni, Francesco, Barraja, Paola

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Advances in developing noncovalent small molecules targeting Keap1 by Barreca, Marilia, Qin, Yuting, Cadot, Marie Elodie Hélène, Barraja, Paola, Bach, Anders

“…Kelch-like ECH-associated protein 1 (Keap1) is a drug target for diseases involving oxidative stress and inflammation. There are three covalent Keap1-binding…”
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Insight on pyrimido[5,4-g]indolizine and pyrimido[4,5-c]pyrrolo[1,2-a]azepine systems as promising photosensitizers on malignant cells by Barreca, Marilia, Ingarra, Angela Maria, Raimondi, Maria Valeria, Spanò, Virginia, De Franco, Michele, Menilli, Luca, Gandin, Valentina, Miolo, Giorgia, Barraja, Paola, Montalbano, Alessandra

“…Searching for new small molecules as photosensitizing agents, we have developed a class of twenty-five pyrimido[5,4-g]indolizine and…”
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Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line by Labbozzetta, Manuela, Barreca, Marilia, Spanò, Virginia, Raimondi, Maria Valeria, Poma, Paola, Notarbartolo, Monica, Barraja, Paola, Montalbano, Alessandra

“…A series of [1,2]oxazolo[5,4‐e]isoindole derivatives was evaluated against HL‐60 cell line and its multidrug resistance (MDR) variant, HL‐60R, resistant to…”
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Synthesis of 2H-Imidazo[2′,1':2,3] [1,3]thiazolo[4,5-e]isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations by Cilibrasi, Vincenzo, Spanò, Virginia, Bortolozzi, Roberta, Barreca, Marilia, Raimondi, Maria Valeria, Rocca, Roberta, Maruca, Annalisa, Montalbano, Alessandra, Alcaro, Stefano, Ronca, Roberto, Viola, Giampietro, Barraja, Paola

“…Despite progressive advances in understanding the molecular biology of acute myeloid leukemia (AML), the conventional therapeutic approach has not changed…”
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Insight into non-nucleoside triazole-based systems as viral polymerases inhibitors by Bivacqua, Roberta, Barreca, Marilia, Spanò, Virginia, Raimondi, Maria Valeria, Romeo, Isabella, Alcaro, Stefano, Andrei, Graciela, Barraja, Paola, Montalbano, Alessandra

“…Viruses have been recognized as the etiological agents responsible for many pathological conditions ranging from asymptomatic infections to serious diseases,…”
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Pyrrolo[2′,3′:3,4]cyclohepta[1,2‑d][1,2]­oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types by Spanò, Virginia, Rocca, Roberta, Barreca, Marilia, Giallombardo, Daniele, Montalbano, Alessandra, Carbone, Anna, Raimondi, Maria Valeria, Gaudio, Eugenio, Bortolozzi, Roberta, Bai, Ruoli, Tassone, Pierfrancesco, Alcaro, Stefano, Hamel, Ernest, Viola, Giampietro, Bertoni, Francesco, Barraja, Paola

“…A new class of pyrrolo­[2′,3′:3,4]­cyclohepta­[1,2-d]­[1,2]­oxazoles was synthesized for the treatment of hyperproliferative pathologies, including neoplasms…”
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Identification of pyrrolo[3′,4’:3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas by Barreca, Marilia, Spanò, Virginia, Rocca, Roberta, Bivacqua, Roberta, Gualtieri, Gianmarco, Raimondi, Maria Valeria, Gaudio, Eugenio, Bortolozzi, Roberta, Manfreda, Lorenzo, Bai, Ruoli, Montalbano, Alessandra, Alcaro, Stefano, Hamel, Ernest, Bertoni, Francesco, Viola, Giampietro, Barraja, Paola

“…Unsatisfactory outcomes for relapsed/refractory lymphoma patients prompt continuing efforts to develop new therapeutic strategies. Our previous studies on…”
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Current development of CFTR potentiators in the last decade by Spanò, Virginia, Venturini, Arianna, Genovese, Michele, Barreca, Marilia, Raimondi, Maria Valeria, Montalbano, Alessandra, Galietta, Luis J.V., Barraja, Paola

“…Cystic fibrosis (CF) is a genetic disorder produced by the loss of function of CFTR, a main chloride channel involved in transepithelial salt and water…”
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