Search Results - "Barreca, Federica"
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Sirtuins and Hypoxia in EMT Control
Published in Pharmaceuticals (Basel, Switzerland) (10-06-2022)“…Epithelial–mesenchymal transition (EMT), a physiological process during embryogenesis, can become pathological in the presence of different driving forces…”
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Pharmacological Activation of SIRT3 Modulates the Response of Cancer Cells to Acidic pH
Published in Pharmaceuticals (Basel, Switzerland) (20-06-2024)“…Cancer cells modulate their metabolism, creating an acidic microenvironment that, in turn, can favor tumor progression and chemotherapy resistance. Tumor cells…”
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Infertility in Fabry's Disease: role of hypoxia and inflammation in determining testicular damage
Published in Frontiers in endocrinology (Lausanne) (22-02-2024)“…Fabry's disease (FD) is a genetic X-linked systemic and progressive rare disease characterized by the accumulation of globotriaosylceramide (GB3) into the…”
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Corrigendum: Infertility in Fabry's disease: role of hypoxia and inflammation in determining testicular damage
Published in Frontiers in endocrinology (Lausanne) (18-04-2024)“…[This corrects the article DOI: 10.3389/fendo.2024.1340188.]…”
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SIRT5 Activation and Inorganic Phosphate Binding Reduce Cancer Cell Vitality by Modulating Autophagy/Mitophagy and ROS
Published in Antioxidants (01-08-2023)“…Cancer cells show increased glutamine consumption. The glutaminase (GLS) enzyme controls a limiting step in glutamine catabolism. Breast tumors, especially the…”
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Mesophotic and Bathyal Palaemonid Shrimp Diversity of the Red Sea, with the Establishment of Two New Genera and Two New Species
Published in Diversity (Basel) (01-09-2023)“…The diversity and evolution of the Red Sea invertebrates in mesophotic and deep-water benthic ecosystems remain largely unexplored. The Palaemonidae is a…”
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Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells
Published in Cells (Basel, Switzerland) (14-01-2019)“…Metformin has been shown to inhibit glutaminase (GLS) activity and ammonia accumulation thereby reducing the risk of hepatic encephalopathy in type 2 diabetic…”
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Putative Receptors for Gravity Sensing in Mammalian Cells: The Effects of Microgravity
Published in Applied sciences (01-03-2020)“…Gravity is a constitutive force that influences life on Earth. It is sensed and translated into biochemical stimuli through the so called “mechanosensors”,…”
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Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery
Published in Cells (Basel, Switzerland) (22-02-2023)“…Life on Earth has evolved in the presence of a gravity constraint. Any change in the value of such a constraint has important physiological effects. Gravity…”
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Consistent Symbiodiniaceae community assemblage in a mesophotic-specialist coral along the Saudi Arabian Red Sea
Published in Frontiers in Marine Science (26-03-2024)“…The Red Sea is a narrow rift basin characterized by latitudinal environmental gradients which shape the diversity and distribution of reef-dwelling organisms…”
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Sirtuins' control of autophagy and mitophagy in cancer
Published in Pharmacology & therapeutics (Oxford) (01-05-2021)“…Mammalian cells use a specialized and complex machinery for the removal of altered proteins or dysfunctional organelles. Such machinery is part of a mechanism…”
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High mobility group box 1 in women with unexplained recurrent pregnancy loss
Published in Journal of perinatal medicine (27-11-2023)“…To investigate whether high mobility group box 1 (HMGB1) is involved in unexplained recurrent pregnancy loss (uRPL). Plasma levels of HMGB1 were measured by…”
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Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity
Published in Journal of medicinal chemistry (08-02-2024)“…Sirtuins are NAD+-dependent protein lysine deacylases implicated in aging-related diseases. Mammalian Sirtuin 4 (Sirt4) is located in mitochondria and a…”
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Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells
Published in Journal of medicinal chemistry (27-07-2023)“…The mitochondrial SIRT3 modulates several biological pathways such as cancer, metabolism, and hypoxia-related diseases. Recently, we discovered new…”
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