Search Results - "Barratt, M.D."

Quantitative structure-activity relationships for skin permeability by Barratt, M.D.

“…In vitro human skin permeability coefficient data collected by Flynn (1990) have been analysed using multiple regression analysis. An improved model for the…”
Get full text

Quantitative structure-activity relationships (QSARs) for skin corrosivity of organic acids, bases and phenols: Principal components and neural network analysis of extended datasets by Barratt, M.D.

“…Quantitative structure-activity relationships (QSARs) relating skin corrosivity data of organic acids, bases and phenols to their log(octanol/water partition…”
Get full text

The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 1. Selection and Distribution of the Test Chemicals by Barratt, M.D., Brantom, P.G., Fentem, J.H., Gerner, I., Walker, A.P., Worth, A.P.

“…An international validation study on in vitro tests for skin corrosivity was conducted during 1996 and 1997 under the auspices of the European Centre for the…”
Get full text

Quantitative structure—Activity relationships for skin irritation and corrosivity of neutral and electrophilic organic chemicals by Barratt, M.D.

“…Quantitative structure-activity relationships (QSARs) have been derived by relating skin irritation and corrosivity data of neutral and electrophilic organic…”
Get full text

An alternative strategy to the use of guinea pigs for the identification of skin sensitization hazard by Basketter, D.A., Scholes, E.W., Chamberlain, M., Barratt, M.D.

“…For over half a century, guinea pig methods have dominated the field of toxicology concerned with the identification of skin sensitizers. Specific protocols,…”
Get full text

Skin corrosivity potential of fatty acids: In vitro rat and human skin testing and QSAR studies by Whittle, E., Barratt, M.D., Carter, J.A., Basketter, D.A., Chamberlain, M.

“…The corrosive potential of a series of fatty acids—propanoic acid (C3), butanoic acid (C4), hexanoic acid (C6), octanoic acid (C8), decanoic acid (C10) and…”
Get full text

Effect of chain length on the stability of lecithin bilayers by Hauser, H, Barratt, M D

Get more information

Structure-activity relationships and prediction of the phototoxicity and phototoxic potential of new drugs by Barratt, M.D

“…Relationships between the structure and properties of chemicals can be programmed into knowledge-based systems such as DEREK for Windows (DEREK is an acronym…”
Get full text

Development and prevalidation of a list of structure-activity relationship rules to be used in expert systems for prediction of the skin-sensitising properties of chemicals by Gerner, I, Barratt, M.D, Zinke, S, Schlegel, K, Schlede, E

“…The new European Union (EU) chemicals policy, as described in the White Paper entitled Strategy for a Future Chemicals Policy, has identified a need for…”
Get full text

Computer prediction of possible toxic action from chemical structure: an update on the DEREK system by Ridings, J.E., Barratt, M.D., Cary, R., Earnshaw, C.G., Eggington, C.E., Ellis, M.K., Judson, P.N., Langowski, J.J., Marchant, C.A., Payne, M.P., Watson, W.P., Yih, T.D.

“…Computer-based assessment of potential toxicity has become increasingly popular in recent years. The knowledgebase system DEREK is developed under the guidance…”
Get full text

The microstructure and properties of IN718 rings produced by centrifugal spray deposition by Barratt, M.D., Dowson, A.L., Jacobs, M.H.

“…Centrifugal spray deposition (CSD) is explored as an alternative route for manufacturing ring-shaped pre-forms for casings in gas turbines. CSD offers…”
Get full text

Skin irritation potential of mixed surfactant systems by Hall-Manning, T.J., Holland, G.H., Rennie, G., Revell, P., Hines, J., Barratt, M.D., Basketter, D.A.

“…Virtually all current detergent formulations contain mixtures of surfactants. Our experience and test data on these formulations, which is in agreement with…”
Get full text

Comparison of an in vitro cellular phototoxicity model against controlled clinical trials of fluoroquinolone skin phototoxicity by Traynor, N.J., Barratt, M.D., Lovell, W.W., Ferguson, J., Gibbs, N.K.

“…Many therapeutic drugs induce phototoxic skin responses following exposure to solar or artificial ultraviolet radiation sources. Several in vitro model systems…”
Get full text

QSARS for the eye irritation potential of neutral organic chemicals by Barratt, M.D.

“…A quantitative structure-activity relationship (QSAR) was derived previously relating European Community (EC) eye irritation classification data of a set of…”
Get full text

A QSAR model for the eye irritation of cationic surfactants by Patlewicz, G.Y., Rodford, R.A., Ellis, G., Barratt, M.D.

“…A QSAR model for the eye irritation of cationic surfactants has been constructed using a dataset consisting of the maximum average scores (MAS—accordance to…”
Get full text

Practical applications of QSAR to in vitro toxicology illustrated by consideration of eye irritation by Chamberlain, M., Barratt, M.D.

“…Mechanistically based quantitative structure-activity relationships (QSARs) have been developed for some well defined toxic endpoints. Principal components…”
Get full text

The use of in vitro cytotoxicity measurements in QSAR methods for the prediction of the skin corrosivity potential of acids by Barratt, M.D., Dixit, M.B., Jones, P.A.

“…Quantitative structure-activity relationships (QSAR) methods have been derived that relate the severity of skin corrosivity (designated by the EC risk phrases…”
Get full text

In vitro investigations of the direct effects of complex anions on thyroidal iodide uptake: Identification of novel inhibitors by Jones, P.A., Pendlington, R.U., Earl, L.K., Sharma, R.K., Barratt, M.D.

“…Iodide uptake (IU) by thyrocytes from the plasma against chemical and electrical gradients is by a specific iodide transporter or ‘pump’. Perchlorate (ClO 4 −)…”
Get full text

Differences in the interaction of inorganic and organic (hydrophobic) cations with phosphatidylserine membranes by Hauser, H, Phillips, M C, Barratt, M D

“…The interaction of phosphatidylserine dispersions with "hydrophobic", organic cations (acetylcholine, tetraethylammonium ion) is compared with that of simple…”
Get more information

Radicals involved in photoallergen/protein interactions by Delahanty, J N, Evans, J C, Rowlands, C C, Barratt, M D, Pendlington, R U

“…Aqueous solutions (pH = 8) of both 3,3'-dimethyl and 4,4'-dimethyl substituted analogues of the photoallergen fentichlor…”
Get more information