Search Results - "Barrat, F J"

Signalling pathways leading to IFN‐α production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications by Guiducci, C., Coffman, R. L., Barrat, F. J.

“… Plasmacytoid dendritic cells (PDC) are highly specialized immune cells capable of producing large amounts of type I and III IFN in response to viral…”
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Griscelli disease maps to chromosome 15q21 and is associated with mutations in the Myosin-Va gene by Griscelli, Claude, Pastural, Elodie, Jabado, Nada, Fischer, Alain, Basile, Geneviève de Saint, Barrat, Franck J, Dufourcq-Lagelouse, Rémi, Sanal, Ozden, Seger, Reinhard, Certain, Stéphanie

“…Griscelli disease (OMIM 214450) is a rare autosomal recessive disorder characterized by pigmentary dilution, variable cellular immunodeficiency and onset of…”
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A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production by Neighbors, M, Xu, X, Barrat, F J, Ruuls, S R, Churakova, T, Debets, R, Bazan, J F, Kastelein, R A, Abrams, J S, O'Garra, A

“…The stimulation of interferon (IFN)-gamma by interleukin (IL)-12 has been shown to provide protection from intracellular pathogens such as Listeria…”
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Genetic and physical mapping of the Chediak-Higashi syndrome on chromosome 1q42-43 by BARRAT, F. J, AULOGE, L, PASTURAL, E, DUFOURCQ LAGELOUSE, R, VILMER, E, CANT, A. J, WEISSENBACH, J, LE PASLIER, D, FISCHER, A, DE SAINT BASILE, G

“…The Chediak-Higashi syndrome (CHS) is a severe autosomal recessive condition, features of which are partial oculocutaneous albinism, increased susceptibility…”
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Genetic basis of hemophagocytic lymphohistiocytosis syndrome (Review) by Dufourcq-Lagelouse, R, Pastural, E, Barrat, F J, Feldmann, J, Le Deist, F, Fischer, A, De Saint Basile, G

“…The group of immune disorders which leads to the occurrence of hemophagocytic lymphohistiocytosis (HLH) syndrome presents a strange paradox in that patients…”
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Identification of Mutations in Two Major mRNA Isoforms of the Chediak-Higashi Syndrome Gene in Human and Mouse by Barbosa, Maria D. F. S., Barrat, Franck J., Tchernev, Velizar T., Nguyen, Quan A., Mishra, Vishnu S., Colman, Steven D., Pastural, Elodie, Dufourcq-Lagelouse, Rémi, Fischer, Alain, Holcombe, Randall F., Wallace, Margaret R., Brandt, Stephen J., de Saint Basile, Geneviève, Kingsi'mora, Stephen F.

“…Chediak-Higashi syndrome is an autosomal recessive, immune deficiency disorder of human (CHS) and mouse (beige, bg) that is characterized by abnormal…”
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Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice by Chensue, S W, Lukacs, N W, Yang, T Y, Shang, X, Frait, K A, Kunkel, S L, Kung, T, Wiekowski, M T, Hedrick, J A, Cook, D N, Zingoni, A, Narula, S K, Zlotnik, A, Barrat, F J, O'Garra, A, Napolitano, M, Lira, S A

“…Chemokine receptors transduce signals important for the function and trafficking of leukocytes. Recently, it has been shown that CC chemokine receptor (CCR)8…”
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Localization of the rab escort protein-2 (REP2) and inositol 1,4,5-trisphosphate 3-kinase (ITPKB) genes to mouse chromosome 1 by in situ hybridization and precision of the syntenic regions between mouse and human 1q42-q44 by BARRAT, F. J, DEPETRIS, D, CERTAIN, S, MATTEI, M.-G, DE SAINT BASILE, G

“…A short genomic region of homology has been identified between the telomeric end of human chromosome 1 and the proximal end of mouse chromosome 13. This region…”
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Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma by Heath, V L, Showe, L, Crain, C, Barrat, F J, Trinchieri, G, O'Garra, A

“…The IL-12 receptor-beta 2 (IL-12R beta 2) chain is expressed on Th1 cells and lost upon differentiation to the Th2 phenotype. This has been suggested as the…”
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Defective CTLA-4 Cycling Pathway in Chediak-Higashi Syndrome: A Possible Mechanism for Deregulation of T Lymphocyte Activation by Barrat, Franck J., Le Deist, Françoise, Benkerrou, Malika, Bousso, Philippe, Feldmann, Jérome, Fischer, Alain, Geneviève de Saint Basile

“…Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4, also known as CD152) has been shown to play a major role in the regulation of T cell activation. Its…”
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1α,25-Dihydroxyvitamin D3 Has a Direct Effect on Naive CD4+ T Cells to Enhance the Development of Th2 Cells by Boonstra, André, Barrat, Franck J., Crain, Chad, Heath, Victoria L., Savelkoul, Huub F. J., O’Garra, Anne

“…1α,25-Dihydroxyvitamin D3 (vitD3) is an immunoregulatory hormone with beneficial effects on Th1 mediated autoimmune diseases. Although the inhibitory effects…”
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Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: Involvement of HMGB1 in anti-DNA antibody-induced renal injury by Qing, Xiaoping, Pitashny, Milena, Thomas, David B, Barrat, Franck J, Hogarth, Mark P, Putterman, Chaim

“…Abstract Although anti-DNA antibodies have been decisively linked to the pathogenesis of lupus nephritis, the mechanisms have not been conclusively determined…”
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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus by Barrat, Franck J, Meeker, Thea, Gregorio, Josh, Chan, Jean H, Uematsu, Satoshi, Akira, Shizuo, Chang, Bonnie, Duramad, Omar, Coffman, Robert L

“…Raised serum levels of interferon (IFN)-alpha have been observed in systemic lupus erythematosus (SLE) patients, and these levels are correlated with both…”
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Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients by Xystrakis, Emmanuel, Kusumakar, Siddharth, Boswell, Sandra, Peek, Emma, Urry, Zoë, Richards, David F, Adikibi, Tonye, Pridgeon, Carol, Dallman, Margaret, Loke, Tuck-Kay, Robinson, Douglas S, Barrat, Franck J, O'Garra, Anne, Lavender, Paul, Lee, Tak H, Corrigan, Christopher, Hawrylowicz, Catherine M

“…We previously reported that human CD4+ Tregs secrete high levels of IL-10 when stimulated in the presence of dexamethasone and calcitriol (vitamin D3). We now…”
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IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells by Vieira, Pedro L, Christensen, Jillian R, Minaee, Sophie, O'Neill, Emma J, Barrat, Franck J, Boonstra, Andre, Barthlott, Thomas, Stockinger, Brigitta, Wraith, David C, O'Garra, Anne

“…Regulatory T cells (T(Reg)) control immune responses to self and nonself Ags. The relationship between Ag-driven IL-10-secreting T(Reg) (IL-10-T(Reg)) and…”
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In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines by Barrat, Franck J, Cua, Daniel J, Boonstra, André, Richards, David F, Crain, Chad, Savelkoul, Huub F, de Waal-Malefyt, René, Coffman, Robert L, Hawrylowicz, Catherine M, O'Garra, Anne

“…We show that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4(+) T cells to differentiate in vitro…”
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In vitro generation of IL-10-producing regulatory CD4 super(+) T cells is induced by immunosuppressive drugs and inhibited by Th1- and Th2-inducing cytokines by O'Garra, A, Barrat, F J

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Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses by Yang, Kun, Puel, Anne, Zhang, Shenying, Eidenschenk, Céline, Ku, Cheng-Lung, Casrouge, Armanda, Picard, Capucine, von Bernuth, Horst, Senechal, Brigitte, Plancoulaine, Sabine, Al-Hajjar, Sami, Al-Ghonaium, Abdulaziz, Maródi, László, Davidson, Donald, Speert, David, Roifman, Chaim, Garty, Ben-Zion, Ozinsky, Adrian, Barrat, Franck J., Coffman, Robert L., Miller, Richard L., Li, Xiaoxia, Lebon, Pierre, Rodriguez-Gallego, Carlos, Chapel, Helen, Geissmann, Frédéric, Jouanguy, Emmanuelle, Casanova, Jean-Laurent

“…Five TLRs are thought to play an important role in antiviral immunity, sensing viral products and inducing IFN-α/β and -λ. Surprisingly, patients with a defect…”
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Défauts génétiques du contrôle de l'activation T évoluant vers un syndrome d'activation lymphohistiocytaire by Dufourcq-Lagelouse, R., Pastural, E., Barrat, F.J., Le Deist, F., Fischer, A., de Saint Basile, G.

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Inhibitors of TLR-9 Act on Multiple Cell Subsets in Mouse and Man In Vitro and Prevent Death In Vivo from Systemic Inflammation by Duramad, Omar, Fearon, Karen L, Chang, Bonnie, Chan, Jean H, Gregorio, Josh, Coffman, Robert L, Barrat, Franck J

“…In parallel with the discovery of the immunostimulatory activities of CpG-containing oligodeoxynucleotides, several groups have reported specific DNA sequences…”
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