Importance of portal hypertension in the release of tissue plasminogen activator (t-PA): experimental study in the rat

Tissue plasminogen activator (t-PA) activity was studied in three different experimental models of male Wistar rats; hepatic lesion without portal hypertension, portal hypertension without hepatic lesion and portal hypertension plus function liver suppression by ligation of both portal vein and hepa...

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Bibliographic Details
Published in:	Revista española de enfermedades digestivas Vol. 84; no. 2; p. 105
Main Authors:	Barrao Comps, F, Lasierra Cirujeda, J, Ceña Lázaro, G, Aza Pascual-Salcedo, M J, Morandeira García, M J, Barrao Yoldi, M E, González Gallego, J
Format:	Journal Article
Language:	Spanish
Published:	Spain 01-08-1993
Subjects:	Animals Hypertension, Portal - etiology Hypertension, Portal - metabolism Liver Diseases - complications Liver Diseases - metabolism Male Rats Rats, Wistar Tissue Plasminogen Activator - secretion
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Summary:	Tissue plasminogen activator (t-PA) activity was studied in three different experimental models of male Wistar rats; hepatic lesion without portal hypertension, portal hypertension without hepatic lesion and portal hypertension plus function liver suppression by ligation of both portal vein and hepatic artery. t-PA activity was higher in animals with portal hypertension alone than in animals with only hepatic lesion (146%). Maximal values were present in animals with functional liver suppression (1.774% vs. controls, 248% vs. hepatic lesion and 169% vs. portal hypertension only). These results suggest that both reduced hepatic t-PA clearance and portal hypertension could be involved in the increased t-PA activity normally appearing in chronic liver disease.
ISSN:	1130-0108