Search Results - "Barraja, Paola"

Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds by Li Petri, Giovanna, Raimondi, Maria Valeria, Spanò, Virginia, Holl, Ralph, Barraja, Paola, Montalbano, Alessandra

“…The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by medicinal chemists to obtain compounds for the treatment of human…”
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HSV-1 Glycoprotein D and Its Surface Receptors: Evaluation of Protein-Protein Interaction and Targeting by Triazole-Based Compounds through In Silico Approaches by Bivacqua, Roberta, Romeo, Isabella, Barreca, Marilia, Barraja, Paola, Alcaro, Stefano, Montalbano, Alessandra

“…Protein-protein interactions (PPI) represent attractive targets for drug design. Thus, aiming at a deeper insight into the HSV-1 envelope glycoprotein D (gD),…”
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Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes by Barreca, Marilia, Spanò, Virginia, Montalbano, Alessandra, Cueto, Mercedes, Díaz Marrero, Ana R, Deniz, Irem, Erdoğan, Ayşegül, Lukić Bilela, Lada, Moulin, Corentin, Taffin-de-Givenchy, Elisabeth, Spriano, Filippo, Perale, Giuseppe, Mehiri, Mohamed, Rotter, Ana, P Thomas, Olivier, Barraja, Paola, Gaudêncio, Susana P, Bertoni, Francesco

“…The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique…”
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Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein by Spanò, Virginia, Barreca, Marilia, Cilibrasi, Vincenzo, Genovese, Michele, Renda, Mario, Montalbano, Alessandra, Galietta, Luis Juan Vicente, Barraja, Paola

“…Cystic fibrosis (CF) is a genetic disease caused by mutations that impair the function of the CFTR chloride channel. The most frequent mutation, F508del,…”
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Insight on [1,3]thiazolo[4,5-e]isoindoles as tubulin polymerization inhibitors by Spanò, Virginia, Barreca, Marilia, Rocca, Roberta, Bortolozzi, Roberta, Bai, Ruoli, Carbone, Anna, Raimondi, Maria Valeria, Piccionello, Antonio Palumbo, Montalbano, Alessandra, Alcaro, Stefano, Hamel, Ernest, Viola, Giampietro, Barraja, Paola

“…A series of [1,3]thiazolo[4,5-e]isoindoles has been synthesized through a versatile and high yielding multistep sequence. Evaluation of the antiproliferative…”
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The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma by Grillone, Katia, Riillo, Caterina, Rocca, Roberta, Ascrizzi, Serena, Spanò, Virginia, Scionti, Francesca, Polerà, Nicoletta, Maruca, Annalisa, Barreca, Marilia, Juli, Giada, Arbitrio, Mariamena, Di Martino, Maria Teresa, Caracciolo, Daniele, Tagliaferri, Pierosandro, Alcaro, Stefano, Montalbano, Alessandra, Barraja, Paola, Tassone, Pierfrancesco

“…Microtubule-targeting agents (MTAs) are effective drugs for cancer treatment. A novel diaryl [1,2]oxazole class of compounds binding the colchicine site was…”
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Preclinical Activity of New [1,2]Oxazolo[5,4‑e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma by Spanò, Virginia, Pennati, Marzia, Parrino, Barbara, Carbone, Anna, Montalbano, Alessandra, Cilibrasi, Vincenzo, Zuco, Valentina, Lopergolo, Alessia, Cominetti, Denis, Diana, Patrizia, Cirrincione, Girolamo, Barraja, Paola, Zaffaroni, Nadia

“…A series of 22 derivatives of the [1,2]­oxazolo­[5,4-e]­isoindole system were synthesized through an efficient and versatile procedure that involves the…”
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Novel tricyclic pyrrolo-quinolines as pharmacological correctors of the mutant CFTR chloride channel by Renda, Mario, Barreca, Marilia, Borrelli, Anna, Spanò, Virginia, Montalbano, Alessandra, Raimondi, Maria Valeria, Bivacqua, Roberta, Musante, Ilaria, Scudieri, Paolo, Guidone, Daniela, Buccirossi, Martina, Genovese, Michele, Venturini, Arianna, Bandiera, Tiziano, Barraja, Paola, Galietta, Luis J. V.

“…F508del, the most frequent mutation in cystic fibrosis (CF), impairs the stability and folding of the CFTR chloride channel, thus resulting in intracellular…”
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New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation by Carbone, Anna, Parrino, Barbara, Cusimano, Maria Grazia, Spanò, Virginia, Montalbano, Alessandra, Barraja, Paola, Schillaci, Domenico, Cirrincione, Girolamo, Diana, Patrizia, Cascioferro, Stella

“…New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive…”
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Synthesis and Antitumor Activity of New Thiazole Nortopsentin Analogs by Spanò, Virginia, Attanzio, Alessandro, Cascioferro, Stella, Carbone, Anna, Montalbano, Alessandra, Barraja, Paola, Tesoriere, Luisa, Cirrincione, Girolamo, Diana, Patrizia, Parrino, Barbara

“…New thiazole nortopsentin analogs in which one of the two indole units was replaced by a naphthyl and/or 7-azaindolyl portion, were conveniently synthesized…”
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Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity by Barreca, Marilia, Spanò, Virginia, Raimondi, Maria Valeria, Tarantelli, Chiara, Spriano, Filippo, Bertoni, Francesco, Barraja, Paola, Montalbano, Alessandra

“…Because of its wide spectrum of targets and biological activities, the oxazole ring is a valuable heterocyclic scaffold in the design of new therapeutic agents…”
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Synthesis and antiproliferative activity of thiazolyl-bis-pyrrolo[2,3-b]pyridines and indolyl-thiazolyl-pyrrolo[2,3-c]pyridines, nortopsentin analogues by Carbone, Anna, Parrino, Barbara, Di Vita, Gloria, Attanzio, Alessandro, Spanò, Virginia, Montalbano, Alessandra, Barraja, Paola, Tesoriere, Luisa, Livrea, Maria Antonia, Diana, Patrizia, Cirrincione, Girolamo

“…Two new series of nortopsentin analogues, in which the imidazole ring of the natural product was replaced by thiazole and indole units were both substituted by…”
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Antibody-drug conjugates for lymphoma patients: preclinical and clinical evidences by Barreca, Marilia, Lang, Noémie, Tarantelli, Chiara, Spriano, Filippo, Barraja, Paola, Bertoni, Francesco

“…Antibody-drug conjugates (ADCs) are a recent, revolutionary approach for malignancies treatment, designed to provide superior efficacy and specific targeting…”
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3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin analogues with antiproliferative activity by Parrino, Barbara, Carbone, Anna, Di Vita, Gloria, Ciancimino, Cristina, Attanzio, Alessandro, Spanò, Virginia, Montalbano, Alessandra, Barraja, Paola, Tesoriere, Luisa, Livrea, Maria Antonia, Diana, Patrizia, Cirrincione, Girolamo

“…A new series of nortopsentin analogues, in which the imidazole ring of the natural product was replaced by thiazole and the indole unit bound to position 2 of…”
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Synthesis and antiproliferative activity of 2,5-bis(3'-indolyl)pyrroles, analogues of the marine alkaloid nortopsentin by Carbone, Anna, Parrino, Barbara, Barraja, Paola, Spanò, Virginia, Cirrincione, Girolamo, Diana, Patrizia, Maier, Armin, Kelter, Gerhard, Fiebig, Heinz-Herbert

“…2,5-bis(3'-Indolyl)pyrroles, analogues of the marine alkaloid nortopsentin, were conveniently prepared through a three step procedure in good overall yields…”
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New Tripentone Analogs with Antiproliferative Activity by Parrino, Barbara, Ullo, Salviana, Attanzio, Alessandro, Spanò, Virginia, Cascioferro, Stella, Montalbano, Alessandra, Barraja, Paola, Tesoriere, Luisa, Cirrincione, Girolamo, Diana, Patrizia

“…Tripentones represent an interesting class of compounds due to their significant cytotoxicity against different human tumor cells in the submicro-nanomolar…”
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Synthesis of the new ring system bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and its deaza analogue by Parrino, Barbara, Spanò, Virginia, Carbone, Anna, Barraja, Paola, Diana, Patrizia, Cirrincione, Girolamo, Montalbano, Alessandra

“…Derivatives of the new ring systems bispyrido[4',3':4,5]pyrrolo[1,2-a:1',2'-d] pyrazine-6,13-dione and its deaza analogue…”
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Investigation of Isoindolo[2,1-a]quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods by Balogh, Balazs, Carbone, Anna, Spanò, Virginia, Montalbano, Alessandra, Barraja, Paola, Cascioferro, Stella, Diana, Patrizia, Parrino, Barbara

“…Isoindolo[2,1-a]quinoxalines constitute an important class of compounds which demonstrated potent antiproliferative activity against different human tumor cell…”
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DNA minor groove binders: an overview on molecular modeling and QSAR approaches by Lauria, Antonino, Montalbano, Alessandra, Barraja, Paola, Dattolo, Gaetano, Almerico, Anna Maria

“…Molecular recognition of DNA by small molecules and proteins is a fundamental problem in structural biology and drug design. Understanding of recognition in…”
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Synthesis of substituted isoindolo[2,1-a]quinoxalin-6-yl–amino and 6-imino-5-yl thiourea derivatives by Parrino, Barbara, Ciancimino, Cristina, Sarwade, Chandrakant, Spanò, Virginia, Montalbano, Alessandra, Barraja, Paola, Cirrincione, Girolamo, Diana, Patrizia, Carbone, Anna

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