ERK activation modulates invasiveness and Reactive Oxygen Species (ROS) production in triple negative breast cancer cell lines

ERK activation modulates invasiveness and Reactive Oxygen Species (ROS) production in triple negative breast cancer cell lines

Triple negative breast cancer (TNBC) is the breast cancer subtype with the worst prognosis and still lacks a targeted therapy. In this study, we found increased ERK phosphorylation in TNBC cell lines and an important role for ERK in sustaining the migration of TNBC cells. Although ROS have been sugg...

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Bibliographic Details
Published in:Cellular signalling Vol. 101; p. 110487
Main Authors: Acosta-Casique, Adilene, Montes-Alvarado, José B., Barragán, Minuet, Larrauri-Rodríguez, Karen A., Perez-Gonzalez, Andrea, Delgado-Magallón, Alam, Millán-Perez-Peña, Lourdes, Rosas-Murrieta, Nora H., Maycotte, Paola
Format: Journal Article
Language:English
Published: England Elsevier Inc 01-01-2023
Subjects:
Breast cancer
Cancer
Cell Line, Tumor
Cell Movement
Cell Proliferation
ERK
Humans
MAPK
Mitogen-Activated Protein Kinase Kinases
Reactive oxygen species
Reactive Oxygen Species - metabolism
Triple negative breast
Triple Negative Breast Neoplasms - metabolism
Reactive oxygen species
PR
Triple negative breast
Breast cancer
MAPK
HER2
TNBC
ER
ERK
Cancer
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Summary:Triple negative breast cancer (TNBC) is the breast cancer subtype with the worst prognosis and still lacks a targeted therapy. In this study, we found increased ERK phosphorylation in TNBC cell lines and an important role for ERK in sustaining the migration of TNBC cells. Although ROS have been suggested to have an important role in sustaining MAPK signaling, antioxidant treatment increased ERK phosphorylation, probably suggesting increased invasive potential. Interestingly, treatment with PD0325901 (PD), a MEK inhibitor, decreased ROS levels in TNBC cells and decreased mitochondrial fragmentation in the MDAMB231 cell line. Our data supports an important role for MEK/ERK in TNBC, sustaining cellular migration, regulating mitochondrial dynamics and ROS production in this breast cancer subtype. •We describe increased ERK phosphorylation in TNBC cell lines.•ERK showed an important role in sustaining cellular migration.•MEK/ERK in TNBC sustains cellular migration, regulating mitochondrial dynamics and ROS production.
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content type line 23
ISSN:0898-6568
1873-3913
DOI:10.1016/j.cellsig.2022.110487