Search Results - "Barrachina, María D."

Succinate receptor mediates intestinal inflammation and fibrosis by Macias-Ceja, Dulce C., Ortiz-Masiá, Dolores, Salvador, Pedro, Gisbert-Ferrándiz, Laura, Hernández, Carlos, Hausmann, Martin, Rogler, Gerhard, Esplugues, Juan V., Hinojosa, Joaquín, Alós, Rafael, Navarro, Francisco, Cosin-Roger, Jesus, Calatayud, Sara, Barrachina, María D.

“…Succinate, an intermediate of the tricarboxylic acid cycle, is accumulated in inflamed areas and its signaling through succinate receptor (SUCNR1) regulates…”
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Stimulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis by Macias‐Ceja, Dulce C, Cosín‐Roger, Jesús, Ortiz‐Masiá, Dolores, Salvador, Pedro, Hernández, Carlos, Esplugues, Juan V, Calatayud, Sara, Barrachina, María D

“…Background and Purpose Defective autophagy contributes to the pathogenesis of inflammatory disorders such as inflammatory bowel disease and there are…”
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Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process by Ortiz-Masià, Dolores, Díez, Irene, Calatayud, Sara, Hernández, Carlos, Cosín-Roger, Jesús, Hinojosa, Joaquín, Esplugues, Juan V, Barrachina, María D

“…Inflammation is part of a complex biological response of vascular tissue to pathogens or damaged cells. First inflammatory cells attempt to remove the…”
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Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development by Ortiz-Masiá, Dolores, Gisbert-Ferrándiz, Laura, Bauset, Cristina, Coll, Sandra, Mamie, Céline, Scharl, Michael, Esplugues, Juan V, Alós, Rafael, Navarro, Francisco, Cosín-Roger, Jesús, Barrachina, María D, Calatayud, Sara

“…The pathogenesis of Crohn's disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process. As succinate and its…”
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The vitamin D receptor Taq I polymorphism is associated with reduced VDR and increased PDIA3 protein levels in human intestinal fibroblasts by Gisbert-Ferrándiz, Laura, Cosin-Roger, Jesus, Hernández, Carlos, Macias-Ceja, Dulce C., Ortiz-Masiá, Dolores, Salvador, Pedro, Wildenberg, ME, Esplugues, Juan V., Alós, Rafael, Navarro, Francisco, Calatayud, Sara, Barrachina, María D.

“…The synonymous single nucleotide polymorphism (SNP) rs731236, located in the vitamin D receptor (VDR) gene (Taq I) has been associated with both decreased…”
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Diminished Vitamin D Receptor Protein Levels in Crohn's Disease Fibroblasts: Effects of Vitamin D by Gisbert-Ferrándiz, Laura, Cosín-Roger, Jesús, Hernández, Carlos, Macias-Ceja, Dulce C, Ortiz-Masiá, Dolores, Salvador, Pedro, Esplugues, Juan V, Hinojosa, Joaquín, Navarro, Francisco, Calatayud, Sara, Barrachina, María D

“…Vitamin D (VD) deficiency has been associated to Crohn's disease (CD) pathogenesis, and the exogenous administration of VD improves the course of the disease,…”
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Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis by Cosin-Roger, Jesus, Canet, Francisco, Macias-Ceja, Dulce C, Gisbert-Ferrándiz, Laura, Ortiz-Masiá, Dolores, Esplugues, Juan V, Alós, Rafael, Navarro, Francisco, Barrachina, María D, Calatayud, Sara

“…We recently observed reduced autophagy in Crohn's disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti-…”
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Autophagy in intestinal fibrosis: relevance in inflammatory bowel disease by Macias-Ceja, Dulce C, Barrachina, María D, Ortiz-Masià, Dolores

“…Chronic inflammation is often associated with fibrotic disorders in which an excessive deposition of extracellular matrix is a hallmark. Long-term fibrosis…”
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M2 macrophages activate WNT signaling pathway in epithelial cells: relevance in ulcerative colitis by Cosín-Roger, Jesús, Ortiz-Masiá, Dolores, Calatayud, Sara, Hernández, Carlos, Alvarez, Angeles, Hinojosa, Joaquin, Esplugues, Juan V, Barrachina, Maria D

“…Macrophages, which exhibit great plasticity, are important components of the inflamed tissue and constitute an essential element of regenerative responses…”
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Profile of Leukocyte-Endothelial Cell Interactions Induced in Venules and Arterioles by Nucleoside Reverse-Transcriptase Inhibitors In Vivo by De Pablo, Carmen, Orden, Samuel, Peris, Jose E., Barrachina, María D., Esplugues, Juan V., Álvarez, Ángeles

“…Background. There is controversy regarding cardiovascular (CV) toxicity of the nucleoside reverse-transcriptase inhibitors used to treat human immunodeficiency…”
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IFNγ-Treated Macrophages Induce EMT through the WNT Pathway: Relevance in Crohn's Disease by Macias-Ceja, Dulce C, Coll, Sandra, Bauset, Cristina, Seco-Cervera, Marta, Gisbert-Ferrándiz, Laura, Navarro, Francisco, Cosin-Roger, Jesus, Calatayud, Sara, Barrachina, María D, Ortiz-Masia, Dolores

“…Fibrosis is a common complication of Crohn's disease (CD) in which macrophages play a central role. Epithelial-mesenchymal transition (EMT) and the WNT pathway…”
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SUCNR1 Mediates the Priming Step of the Inflammasome in Intestinal Epithelial Cells: Relevance in Ulcerative Colitis by Bauset, Cristina, Lis-Lopez, Lluis, Coll, Sandra, Gisbert-Ferrándiz, Laura, Macias-Ceja, Dulce C, Seco-Cervera, Marta, Navarro, Francisco, Esplugues, Juan V, Calatayud, Sara, Ortiz-Masia, Dolores, Barrachina, Maria D, Cosín-Roger, Jesús

“…Intestinal epithelial cells (IECs) constitute a defensive physical barrier in mucosal tissues and their disruption is involved in the etiopathogenesis of…”
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Synthesis of nitric oxide in postganglionic myenteric neurons during endotoxemia: implications for gastric motor function in rats by Quintana, Elsa, Hernández, Carlos, Alvarez-Barrientos, Alberto, Esplugues, Juan V, Barrachina, María D

“…We have investigated the mechanisms underlying acute changes in gastric motor function triggered by endotoxemia. In fundal strips from rats pre-treated with…”
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ER stress in human hepatic cells treated with Efavirenz: Mitochondria again by Apostolova, Nadezda, Gomez-Sucerquia, Leysa J, Alegre, Fernando, Funes, Haryes A, Victor, Victor M, Barrachina, Maria D, Blas-Garcia, Ana, Esplugues, Juan V

“…Background & Aims ER stress is associated with a growing number of liver diseases, including drug-induced hepatotoxicity. The non-nucleoside analogue reverse…”
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Transcriptional up-regulation of nNOS in the dorsal vagal complex during low endotoxemia by Quintana, Elsa, Hernández, Carlos, Moran, Anthony P., Esplugues, Juan V., Barrachina, María D.

“…The present study analyses the expression and distribution of neuronal nitric oxide synthase (nNOS) in the brainstem of animals pre-treated with Escherichia…”
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The flesh ethanolic extract of Hylocereus polyrhizus exerts anti-inflammatory effects and prevents murine colitis by Macias-Ceja, Dulce C, Cosín-Roger, Jesus, Ortiz-Masiá, Dolores, Salvador, Pedro, Hernández, Carlos, Calatayud, Sara, Esplugues, Juan V, Barrachina, Maria D

“…Abstract Background & aims IBD is a chronic disorder of the gastrointestinal tract characterized by mucosal inflammation and epithelial damage. Biologic…”
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Efavirenz induces interactions between leucocytes and endothelium through the activation of Mac-1 and gp150,95 by Orden, Samuel, De Pablo, Carmen, Rios-Navarro, Cesar, Martinez-Cuesta, Maria Angeles, Peris, Jose E., Barrachina, Maria D., Esplugues, Juan V., Alvarez, Angeles

“…Objectives The potential cardiovascular (CV) toxicity associated with combined antiretroviral therapy (cART) has been attributed mainly to the nucleoside…”
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iNOS-derived nitric oxide mediates the increase in TFF2 expression associated with gastric damage: role of HIF-1 by Ortiz-Masiá, Dolores, Hernández, Carlos, Quintana, Elsa, Velázquez, Miriam, Cebrián, Sonia, Riaño, Annia, Calatayud, Sara, Esplugues, Juan V, Barrachina, Maria D

“…Trefoil (TFF) peptides are involved in gastrointestinal mucosal restitution. An hypoxia inducible factor 1 (HIF-1)-dependent induction of TFF genes has been…”
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S timulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis by Macias‐Ceja, Dulce C, Cosín‐Roger, Jesús, Ortiz‐Masiá, Dolores, Salvador, Pedro, Hernández, Carlos, Esplugues, Juan V, Calatayud, Sara, Barrachina, María D

“…Background and Purpose Defective autophagy contributes to the pathogenesis of inflammatory disorders such as inflammatory bowel disease and there are…”
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WNT2b Activates Epithelial-mesenchymal Transition Through FZD4: Relevance in Penetrating Crohn´s Disease by Ortiz-Masià, Dolores, Salvador, Pedro, Macias-Ceja, Dulce C, Gisbert-Ferrándiz, Laura, Esplugues, Juan V, Manyé, Josep, Alós, Rafael, Navarro-Vicente, Francisco, Mamie, Céline, Scharl, Michael, Cosin-Roger, Jesus, Calatayud, Sara, Barrachina, María D

“…Abstract Background and Aims Epithelial-mesenchymal transition [EMT] has been related to fibrosis and fistula formation, common complications associated with…”
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