Search Results - "Barr, Valarie A."

Hierarchical nanostructure and synergy of multimolecular signalling complexes by Sherman, Eilon, Barr, Valarie A., Merrill, Robert K., Regan, Carole K., Sommers, Connie L., Samelson, Lawrence E.

“…Signalling complexes are dynamic, multimolecular structures and sites for intracellular signal transduction. Although they play a crucial role in cellular…”
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Collective Cell Migration Requires Vesicular Trafficking for Chemoattractant Delivery at the Trailing Edge by Kriebel, Paul W., Barr, Valarie A., Rericha, Erin C., Zhang, Guofeng, Parent, Carole A.

“…Chemoattractant signaling induces the polarization and directed movement of cells secondary to the activation of multiple effector pathways. In addition,…”
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Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells by Coussens, Nathan P., Hayashi, Ryo, Brown, Patrick H., Balagopalan, Lakshmi, Balbo, Andrea, Akpan, Itoro, Houtman, Jon C. D., Barr, Valarie A., Schuck, Peter, Appella, Ettore, Samelson, Lawrence E.

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15 kDa granulysin causes differentiation of monocytes to dendritic cells but lacks cytotoxic activity by Clayberger, Carol, Finn, Michael W, Wang, Tianhong, Saini, Reena, Wilson, Christine, Barr, Valarie A, Sabatino, Marianna, Castiello, Luciano, Stroncek, David, Krensky, Alan M

“…Granulysin is expressed as two isoforms by human cytotoxic cells: a single mRNA gives rise to 15 kDa granulysin, a portion of which is cleaved to a 9 kDa…”
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Endocytic events in TCR signaling: focus on adapters in microclusters by Balagopalan, Lakshmi, Barr, Valarie A, Samelson, Lawrence E

“…Although the critical role of T-cell receptor (TCR) microclusters in T-cell activation is now widely accepted, the mechanisms of regulation of these TCR-rich…”
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c-Cbl-Mediated Regulation of LAT-Nucleated Signaling Complexes by Balagopalan, Lakshmi, Barr, Valarie A., Sommers, Connie L., Barda-Saad, Mira, Goyal, Amrita, Isakowitz, Matthew S., Samelson, Lawrence E.

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Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation by Balagopalan, Lakshmi, Ashwell, Benjamin A, Bernot, Kelsie M, Akpan, Itoro O, Quasba, Naeha, Barr, Valarie A, Samelson, Lawrence E

“…Linker for activation of T cells (LAT) plays a central role in T-cell activation by nucleating signaling complexes that are critical for the propagation of…”
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Persistence of Cooperatively Stabilized Signaling Clusters Drives T-Cell Activation by Bunnell, Stephen C., Singer, Andrew L., Hong, David I., Jacque, Berri H., Jordan, Martha S., Seminario, Maria-Cristina, Barr, Valarie A., Koretzky, Gary A., Samelson, Lawrence E.

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Src-Dependent Phosphorylation of ASAP1 Regulates Podosomes by Bharti, Sanita, Inoue, Hiroki, Bharti, Kapil, Hirsch, Dianne S., Nie, Zhongzhen, Yoon, Hye-Young, Artym, Vira, Yamada, Kenneth M., Mueller, Susette C., Barr, Valarie A., Randazzo, Paul A.

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The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters by Balagopalan, Lakshmi, Kortum, Robert L., Coussens, Nathan P., Barr, Valarie A., Samelson, Lawrence E.

“…Since the cloning of the critical adapter, LAT (linker for activation of T cells), more than 15 years ago, a combination of multiple scientific approaches and…”
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Formation of STIM and Orai complexes: puncta and distal caps by Barr, Valarie A, Bernot, Kelsie M, Shaffer, Meredith H, Burkhardt, Janis K, Samelson, Lawrence E

“…In the last few years, great progress has been made in understanding how stromal interacting molecule 1 (STIM1), a protein containing a calcium sensor that is…”
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Insulin Stimulates Both Leptin Secretion and Production by Rat White Adipose Tissue by Barr, Valarie A, Malide, Daniela, Zarnowski, Mary Jane, Taylor, Simeon I, Cushman, Samuel W

“…Leptin, the peptide encoded by the obese gene, is secreted by adipose cells and plays a role in regulating food intake, energy expenditure, and adiposity…”
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Recruitment of calcineurin to the TCR positively regulates T cell activation by Dutta, Debjani, Barr, Valarie A, Akpan, Itoro, Mittelstadt, Paul R, Singha, Laishram I, Samelson, Lawrence E, Ashwell, Jonathan D

“…The phosphatase calcineurin targets NFAT transcription factors in T cells. Ashwell and colleagues show that calcineurin is recruited to the TCR signaling…”
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Imaging techniques for assaying lymphocyte activation in action by Samelson, Lawrence E, Balagopalan, Lakshmi, Sherman, Eilon, Barr, Valarie A

“…Key Points In vivo imaging has shown that the interaction of lymphocytes and antigen-presenting cells (APCs), as well as lymphocyte motility, depend on the…”
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madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy by Yi, Jason, Manna, Asit, Barr, Valarie A, Hong, Jennifer, Neuman, Keir C, Samelson, Lawrence E

“…Investigation of heterogeneous cellular structures using single-molecule localization microscopy has been limited by poorly defined localization accuracy and…”
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Heterogeneity of Signaling Complex Nanostructure in T Cells Activated Via the T Cell Antigen Receptor by Barr, Valarie A, Piao, Juan, Balagopalan, Lakshmi, McIntire, Katherine M, Schoenberg, Frederic P, Samelson, Lawrence E

“…Activation of the T cell antigen receptor (TCR) is a key step in initiating the adaptive immune response. Single-molecule localization techniques have been…”
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Bam32: a novel mediator of Erk activation in T cells by Sommers, Connie L., Gurson, Jordan M., Surana, Rishi, Barda-Saad, Mira, Lee, Jan, Kishor, Aparna, Li, WenMei, Gasser, Adam J., Barr, Valarie A., Miyaji, Michihiko, Love, Paul E., Samelson, Lawrence E.

“…Bam32 (B lymphocyte adapter molecule of 32 kDa) is an adapter protein expressed in some hematopoietic cells including B and T lymphocytes. It was previously…”
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Development of nanoscale structure in LAT-based signaling complexes by Barr, Valarie A, Sherman, Eilon, Yi, Jason, Akpan, Itoro, Rouquette-Jazdanian, Alexandre K, Samelson, Lawrence E

“…The adapter molecule linker for activation of T cells (LAT) plays a crucial role in forming signaling complexes induced by stimulation of the T cell receptor…”
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Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling by Balagopalan, Lakshmi, Barr, Valarie A, Kortum, Robert L, Park, Anna K, Samelson, Lawrence E

“…A controversy has recently emerged regarding the location of the cellular pool of the adapter linker for activation of T cells (LAT) that participates in…”
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The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells by Guittard, Geoffrey, Dios-Esponera, Ana, Palmer, Douglas C., Akpan, Itoro, Barr, Valarie A., Manna, Asit, Restifo, Nicholas P., Samelson, Lawrence E.

“…Cish, participates within a multi-molecular E3 ubiquitin ligase complex, which ubiquitinates target proteins. It has an inhibitory effect on T cell activation…”
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