Search Results - "Barr, Rick L"

Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts by MCCORMACK, J. G, BARR, R. L, WOLFF, A. A, LOPASCHUK, G. D

“…Ranolazine is a novel antianginal agent that may reduce symptoms without affecting hemodynamics and has shown cardiac antiischemic effects in in vivo and in…”
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Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation by Dyck, J R, Barr, A J, Barr, R L, Kolattukudy, P E, Lopaschuk, G D

“…Malonyl-CoA is a potent inhibitor of fatty acid uptake into the mitochondria. Although the synthesis of malonyl-CoA in the heart by acetyl-CoA carboxylase…”
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Contribution of malonyl-CoA decarboxylase to the high fatty acid oxidation rates seen in the diabetic heart by Sakamoto, J, Barr, R L, Kavanagh, K M, Lopaschuk, G D

“…Myocardial glucose oxidation is markedly reduced in the uncontrolled diabetic. We determined whether this was due to direct biochemical changes in the heart or…”
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Regulation of myocardial fatty acid oxidation by substrate supply by Longnus, S L, Wambolt, R B, Barr, R L, Lopaschuk, G D, Allard, M F

“…We tested the hypothesis that myocardial substrate supply regulates fatty acid oxidation independent of changes in acetyl-CoA carboxylase (ACC) and…”
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Methodology for measuring in vitro/ex vivo cardiac energy metabolism by Barr, Rick L, Lopaschuk, Gary D

“…The high energy demands of the heart are met primarily by the metabolism of fatty acids and carbohydrates. These energy substrates are efficiently and rapidly…”
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Direct measurement of energy metabolism in the isolated working rat heart by Barr, Rick L., Lopaschuk, Gary D.

“…Fatty acids and carbohydrates are the two main energy substrates used by the heart. Studies involving the regulation of these pathways in the heart have…”
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High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5’-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase by Kudo, Naomi, Barr, Amy J., Barr, Rick L., Desai, Snehal, Lopaschuk, Gary D.

“…We determined whether high fatty acid oxidation rates during aerobic reperfusion of ischemic hearts could be explained by a decrease in malonyl-CoA levels,…”
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Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart by Lopaschuk, G.D, Barr, R.L

“…The isolated working rat heart is a useful experimental model which allows contractile function to be measured in hearts perfused at physiologically relevant…”
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Measurements of fatty acid and carbohydrate metabolism in te isolated working rat heart by Lopaschuk, Gary D, Barr, Rick L

“…The isolated working rat heart is a useful experimental model which allows contractile function to be measured in hearts perfused at physiologically relevant…”
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High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5′-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase by Naomi Kudo, Amy J. Barr, Rick L. Barr, Snehal Desai, Gary D. Lopaschuk

“…We determined whether high fatty acid oxidation rates during aerobic reperfusion of ischemic hearts could be explained by a decrease in malonyl-CoA levels,…”
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Acute insulin withdrawal from diabetic BB rats decreases myocardial glycolysis during low-flow ischemia by Broderick, T L, Barr, R L, Quinney, H A, Lopaschuk, G D

“…We have previously demonstrated that withdrawal of insulin treatment from BB diabetic rats for a 24-hour period will increase the failure rate of hearts…”
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