Search Results - "Barr, Francis A"

Rab GTPases and membrane identity: Causal or inconsequential? by Barr, Francis A.

“…Rab GTPases are highly conserved components of vesicle trafficking pathways that help to ensure the fusion of a vesicle with a specific target organelle…”
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BLOC-3 Mutated in Hermansky-Pudlak Syndrome Is a Rab32/38 Guanine Nucleotide Exchange Factor by Gerondopoulos, Andreas, Langemeyer, Lars, Liang, Jin-Rui, Linford, Andrea, Barr, Francis A.

“…Hermansky-Pudlak syndrome (HPS) is a human disease characterized by partial loss of pigmentation and impaired blood clotting [1–3]. These symptoms are caused…”
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Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP1 and PP2A by Holder, James, Poser, Elena, Barr, Francis A.

“…Here, we will review the evidence showing that mitotic exit is initiated by regulated proteolysis and then driven by the PPP family of phosphoserine/threonine…”
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BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation by Cundell, Michael J, Bastos, Ricardo Nunes, Zhang, Tongli, Holder, James, Gruneberg, Ulrike, Novak, Bela, Barr, Francis A

“…Cytokinesis follows separase activation and chromosome segregation. This order is ensured in budding yeast by the mitotic exit network (MEN), where Cdc14p…”
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Cytokinesis: Placing and Making the Final Cut by Barr, Francis A., Gruneberg, Ulrike

“…Cytokinesis is the process by which cells physically separate after the duplication and spatial segregation of the genetic material. A number of general…”
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Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor by Bräuer, Philipp, Parker, Joanne L, Gerondopoulos, Andreas, Zimmermann, Iwan, Seeger, Markus A, Barr, Francis A, Newstead, Simon

“…Selective export and retrieval of proteins between the endoplasmic reticulum (ER) and Golgi apparatus is indispensable for eukaryotic cell function. An…”
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Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission by Bastos, Ricardo Nunes, Barr, Francis A

“…Cytokinesis requires a membrane-remodeling and fission event termed abscission that occurs after chromosome segregation, cleavage furrow formation, and…”
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MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling by Alfonso-Pérez, Tatiana, Hayward, Daniel, Holder, James, Gruneberg, Ulrike, Barr, Francis A

“…Cyclin B-dependent kinase (CDK1-CCNB1) promotes entry into mitosis. Additionally, it inhibits mitotic exit by activating the spindle checkpoint. This latter…”
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Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle by Serena, Michela, Bastos, Ricardo Nunes, Elliott, Paul R, Barr, Francis A

“…The Aurora B chromosomal passenger complex (CPC) is a conserved regulator of mitosis. Its functions require localization first to the chromosome arms and then…”
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A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit by Cundell, Michael J, Hutter, Lukas H, Nunes Bastos, Ricardo, Poser, Elena, Holder, James, Mohammed, Shabaz, Novak, Bela, Barr, Francis A

“…PP2A-B55 is one of the major phosphatases regulating cell division. Despite its importance for temporal control during mitotic exit, how B55 substrates are…”
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TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes by Longatti, Andrea, Lamb, Christopher A, Razi, Minoo, Yoshimura, Shin-ichiro, Barr, Francis A, Tooze, Sharon A

“…Autophagy is a bulk degradation process characterized by the formation of double membrane vesicles called autophagosomes. The exact molecular mechanism of…”
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Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors by Yoshimura, Shin-ichiro, Gerondopoulos, Andreas, Linford, Andrea, Rigden, Daniel J, Barr, Francis A

“…A key requirement for Rab function in membrane trafficking is site-specific activation by GDP-GTP exchange factors (GEFs), but the majority of the 63 human…”
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Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C by Hsu, Chieh, Morohashi, Yuichi, Yoshimura, Shin-ichiro, Manrique-Hoyos, Natalia, Jung, SangYong, Lauterbach, Marcel A, Bakhti, Mostafa, Grønborg, Mads, Möbius, Wiebke, Rhee, JeongSeop, Barr, Francis A, Simons, Mikael

“…Oligodendrocytes secrete vesicles into the extracellular space, where they might play a role in neuron-glia communication. These exosomes are small vesicles…”
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Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit by Holder, James, Mohammed, Shabaz, Barr, Francis A

“…APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of…”
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KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle by Bastos, Ricardo Nunes, Cundell, Michael J, Barr, Francis A

“…The mitotic kinase Aurora B is concentrated at the anaphase central spindle by the kinesin MKlp2 during mitotic exit and cytokinesis. This pool of Aurora B…”
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CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis by Bastos, Ricardo Nunes, Penate, Xenia, Bates, Michelle, Hammond, Dean, Barr, Francis A

“…In mitosis, animal cells lose their adhesion to the surrounding surfaces and become rounded. During mitotic exit, they reestablish these adhesions and at the…”
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Rab14 and Its Exchange Factor FAM116 Link Endocytic Recycling and Adherens Junction Stability in Migrating Cells by Linford, Andrea, Yoshimura, Shin-ichiro, Bastos, Ricardo Nunes, Langemeyer, Lars, Gerondopoulos, Andreas, Rigden, Daniel J., Barr, Francis A.

“…Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate…”
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Rab18 and a Rab18 GEF complex are required for normal ER structure by Gerondopoulos, Andreas, Bastos, Ricardo Nunes, Yoshimura, Shin-Ichiro, Anderson, Rachel, Carpanini, Sarah, Aligianis, Irene, Handley, Mark T, Barr, Francis A

“…The ancestral Rab GTPase Rab18 and both subunits of the Rab3GAP complex are mutated in the human neurological and developmental disorder Warburg Micro…”
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Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex by Gerondopoulos, Andreas, Strutt, Helen, Stevenson, Nicola L., Sobajima, Tomoaki, Levine, Tim P., Stephens, David J., Strutt, David, Barr, Francis A.

“…A subset of Rab GTPases have been implicated in cilium formation in cultured mammalian cells [1–6]. Rab11 and Rab8, together with their GDP-GTP exchange…”
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Loss-of-Function Mutations in TBC1D20 Cause Cataracts and Male Infertility in blind sterile Mice and Warburg Micro Syndrome in Humans by Liegel, Ryan P., Handley, Mark T., Ronchetti, Adam, Brown, Stephen, Langemeyer, Lars, Linford, Andrea, Chang, Bo, Morris-Rosendahl, Deborah J., Carpanini, Sarah, Posmyk, Renata, Harthill, Verity, Sheridan, Eamonn, Abdel-Salam, Ghada M.H., Terhal, Paulien A., Faravelli, Francesca, Accorsi, Patrizia, Giordano, Lucio, Pinelli, Lorenzo, Hartmann, Britta, Ebert, Allison D., Barr, Francis A., Aligianis, Irene A., Sidjanin, Duska J.

“…blind sterile (bs) is a spontaneous autosomal-recessive mouse mutation discovered more than 30 years ago. Phenotypically, bs mice exhibit nuclear cataracts and…”
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