Search Results - "Barr, Francis"

Rab GTPases and membrane identity: Causal or inconsequential? by Barr, Francis A.

“…Rab GTPases are highly conserved components of vesicle trafficking pathways that help to ensure the fusion of a vesicle with a specific target organelle…”
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BLOC-3 Mutated in Hermansky-Pudlak Syndrome Is a Rab32/38 Guanine Nucleotide Exchange Factor by Gerondopoulos, Andreas, Langemeyer, Lars, Liang, Jin-Rui, Linford, Andrea, Barr, Francis A.

“…Hermansky-Pudlak syndrome (HPS) is a human disease characterized by partial loss of pigmentation and impaired blood clotting [1–3]. These symptoms are caused…”
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Getting out of mitosis: spatial and temporal control of mitotic exit and cytokinesis by PP1 and PP2A by Holder, James, Poser, Elena, Barr, Francis A.

“…Here, we will review the evidence showing that mitotic exit is initiated by regulated proteolysis and then driven by the PPP family of phosphoserine/threonine…”
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BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation by Cundell, Michael J, Bastos, Ricardo Nunes, Zhang, Tongli, Holder, James, Gruneberg, Ulrike, Novak, Bela, Barr, Francis A

“…Cytokinesis follows separase activation and chromosome segregation. This order is ensured in budding yeast by the mitotic exit network (MEN), where Cdc14p…”
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Cytokinesis: Placing and Making the Final Cut by Barr, Francis A., Gruneberg, Ulrike

“…Cytokinesis is the process by which cells physically separate after the duplication and spatial segregation of the genetic material. A number of general…”
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Rab regulation by GEFs and GAPs during membrane traffic by Lamber, Ekaterina P, Siedenburg, Ann-Christin, Barr, Francis A

“…Rab GTPases and their regulatory proteins play a crucial role in vesicle-mediated membrane trafficking. During vesicle membrane tethering Rab GTPases are…”
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Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor by Bräuer, Philipp, Parker, Joanne L, Gerondopoulos, Andreas, Zimmermann, Iwan, Seeger, Markus A, Barr, Francis A, Newstead, Simon

“…Selective export and retrieval of proteins between the endoplasmic reticulum (ER) and Golgi apparatus is indispensable for eukaryotic cell function. An…”
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Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission by Bastos, Ricardo Nunes, Barr, Francis A

“…Cytokinesis requires a membrane-remodeling and fission event termed abscission that occurs after chromosome segregation, cleavage furrow formation, and…”
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Loss-of-Function Mutations in TBC1D20 Cause Cataracts and Male Infertility in blind sterile Mice and Warburg Micro Syndrome in Humans by Liegel, Ryan P., Handley, Mark T., Ronchetti, Adam, Brown, Stephen, Langemeyer, Lars, Linford, Andrea, Chang, Bo, Morris-Rosendahl, Deborah J., Carpanini, Sarah, Posmyk, Renata, Harthill, Verity, Sheridan, Eamonn, Abdel-Salam, Ghada M.H., Terhal, Paulien A., Faravelli, Francesca, Accorsi, Patrizia, Giordano, Lucio, Pinelli, Lorenzo, Hartmann, Britta, Ebert, Allison D., Barr, Francis A., Aligianis, Irene A., Sidjanin, Duska J.

“…blind sterile (bs) is a spontaneous autosomal-recessive mouse mutation discovered more than 30 years ago. Phenotypically, bs mice exhibit nuclear cataracts and…”
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MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling by Alfonso-Pérez, Tatiana, Hayward, Daniel, Holder, James, Gruneberg, Ulrike, Barr, Francis A

“…Cyclin B-dependent kinase (CDK1-CCNB1) promotes entry into mitosis. Additionally, it inhibits mitotic exit by activating the spindle checkpoint. This latter…”
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Molecular basis of MKLP2-dependent Aurora B transport from chromatin to the anaphase central spindle by Serena, Michela, Bastos, Ricardo Nunes, Elliott, Paul R, Barr, Francis A

“…The Aurora B chromosomal passenger complex (CPC) is a conserved regulator of mitosis. Its functions require localization first to the chromosome arms and then…”
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A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit by Cundell, Michael J, Hutter, Lukas H, Nunes Bastos, Ricardo, Poser, Elena, Holder, James, Mohammed, Shabaz, Novak, Bela, Barr, Francis A

“…PP2A-B55 is one of the major phosphatases regulating cell division. Despite its importance for temporal control during mitotic exit, how B55 substrates are…”
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Membrane Traffic: Trans-Golgi Tethers Leave a Surprisingly Small GAP by Barr, Francis A.

“…Activation and inactivation of Rab GTPases by GEFs and GAPs promotes or terminates vesicle tethering to organelles, respectively. This simple model is…”
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TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes by Longatti, Andrea, Lamb, Christopher A, Razi, Minoo, Yoshimura, Shin-ichiro, Barr, Francis A, Tooze, Sharon A

“…Autophagy is a bulk degradation process characterized by the formation of double membrane vesicles called autophagosomes. The exact molecular mechanism of…”
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Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2 by Zeng, Kang, Bastos, Ricardo Nunes, Barr, Francis A, Gruneberg, Ulrike

“…Many protein kinases are activated by a conserved regulatory step involving T-loop phosphorylation. Although there is considerable focus on kinase activator…”
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Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors by Yoshimura, Shin-ichiro, Gerondopoulos, Andreas, Linford, Andrea, Rigden, Daniel J, Barr, Francis A

“…A key requirement for Rab function in membrane trafficking is site-specific activation by GDP-GTP exchange factors (GEFs), but the majority of the 63 human…”
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Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C by Hsu, Chieh, Morohashi, Yuichi, Yoshimura, Shin-ichiro, Manrique-Hoyos, Natalia, Jung, SangYong, Lauterbach, Marcel A, Bakhti, Mostafa, Grønborg, Mads, Möbius, Wiebke, Rhee, JeongSeop, Barr, Francis A, Simons, Mikael

“…Oligodendrocytes secrete vesicles into the extracellular space, where they might play a role in neuron-glia communication. These exosomes are small vesicles…”
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Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit by Holder, James, Mohammed, Shabaz, Barr, Francis A

“…APC/C-mediated proteolysis of cyclin B and securin promotes anaphase entry, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of…”
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KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle by Bastos, Ricardo Nunes, Cundell, Michael J, Barr, Francis A

“…The mitotic kinase Aurora B is concentrated at the anaphase central spindle by the kinesin MKlp2 during mitotic exit and cytokinesis. This pool of Aurora B…”
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Rab14 and Its Exchange Factor FAM116 Link Endocytic Recycling and Adherens Junction Stability in Migrating Cells by Linford, Andrea, Yoshimura, Shin-ichiro, Bastos, Ricardo Nunes, Langemeyer, Lars, Gerondopoulos, Andreas, Rigden, Daniel J., Barr, Francis A.

“…Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate…”
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