Search Results - "Barr, Eric"

Spectroscopic Evidence for the Two C–H-Cleaving Intermediates of Aspergillus nidulans Isopenicillin N Synthase by Tamanaha, Esta, Zhang, Bo, Guo, Yisong, Chang, Wei-chen, Barr, Eric W, Xing, Gang, St. Clair, Jennifer, Ye, Shengfa, Neese, Frank, Bollinger, J. Martin, Krebs, Carsten

“…The enzyme isopenicillin N synthase (IPNS) installs the β-lactam and thiazolidine rings of the penicillin core into the linear tripeptide…”
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G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure by de Lucia, Claudio, Grisanti, Laurel A, Borghetti, Giulia, Piedepalumbo, Michela, Ibetti, Jessica, Lucchese, Anna Maria, Barr, Eric W, Roy, Rajika, Okyere, Ama Dedo, Murphy, Haley Christine, Gao, Erhe, Rengo, Giuseppe, Houser, Steven R, Tilley, Douglas G, Koch, Walter J

“…Abstract Aims  Myocardial infarction (MI) is the most common cause of heart failure (HF) worldwide. G protein-coupled receptor kinase 5 (GRK5) is upregulated…”
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Direct Spectroscopic Detection of a C-H-Cleaving High-Spin Fe(IV) Complex in a Prolyl-4-Hydroxylase by Hoffart, Lee M., Barr, Eric W., Guyer, Robert B., Bollinger, J. Martin, Krebs, Carsten

“…The Fe(ll)- and α-ketoglutarate (αKG)-dependent dioxygenases use mononuclear nonheme iron centers to effect hydroxylation of their substrates and…”
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Two interconverting Fe( IV ) intermediates in aliphatic chlorination by the halogenase CytC3 by Walsh, Christopher T, Bollinger, J Martin, Krebs, Carsten, Galoni, Danica P, Barr, Eric W

“…Enzymatic incorporation of a halogen atom is a common feature in the biosyntheses of more than 4,500 natural products. Halogenation of unactivated carbon…”
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Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2 by Matthews, Megan L, Krest, Courtney M, Barr, Eric W, Vaillancourt, Frédéric H, Walsh, Christopher T, Green, Michael T, Krebs, Carsten, Bollinger, J. Martin

“…Aliphatic halogenases activate O2, cleave α-ketoglutarate (αKG) to CO2 and succinate, and form haloferryl [X−Fe(IV)O; X = Cl or Br] complexes that cleave…”
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Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases by Arosarena, Oneida A., Barr, Eric W., Thorpe, Ryan, Yankey, Hilary, Tarr, Joseph T., Safadi, Fayez F.

“…Nearly 60% of patients with head and neck squamous cell carcinoma (HNSCC) die of metastases or locoregional recurrence. Metastasis is mediated by cancer cell…”
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A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure by Coleman, Ryan C, Eguchi, Akito, Lieu, Melissa, Roy, Rajika, Barr, Eric W, Ibetti, Jessica, Lucchese, Anna-Maria, Peluzzo, Amanda M, Gresham, Kenneth, Chuprun, J Kurt, Koch, Walter J

“…Aberrant changes in gene expression underlie the pathogenesis and progression of pressure-overload heart failure, leading to maladaptive cardiac hypertrophy,…”
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A Long-Lived, Substrate-Hydroxylating Peroxodiiron(III/III) Intermediate in the Amine Oxygenase, AurF, from Streptomyces thioluteus by Korboukh, Victoria Korneeva, Li, Ning, Barr, Eric W, Bollinger, J. Martin, Krebs, Carsten

“…The amine oxygenase AurF from Streptomyces thioluteus catalyzes the six-electron oxidation of p-aminobenzoate (pABA) to p-nitrobenzoate (pNBA). In this work,…”
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Direct Spectroscopic Evidence for a High-Spin Fe(IV) Intermediate in Tyrosine Hydroxylase by Eser, Bekir E, Barr, Eric W, Frantom, Patrick A, Saleh, Lana, Bollinger, J. Martin, Krebs, Carsten, Fitzpatrick, Paul F

“…Tyrosine hydroxylase, a member of the aromatic amino acid hydroxylase family, uses a mononuclear Fe(II) and tetrahydropterin for hydroxylation of tyrosine to…”
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The First Direct Characterization of a High-Valent Iron Intermediate in the Reaction of an α-Ketoglutarate-Dependent Dioxygenase:  A High-Spin Fe(IV) Complex in Taurine/α-Ketoglutarate Dioxygenase (TauD) from Escherichia coli by Price, John C, Barr, Eric W, Tirupati, Bhramara, Bollinger, J. Martin, Krebs, Carsten

“…The Fe(II)- and α-ketoglutarate(αKG)-dependent dioxygenases have roles in synthesis of collagen and sensing of oxygen in mammals, in acquisition of nutrients…”
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Spectroscopic and Computational Evaluation of the Structure of the High-Spin Fe(IV)-Oxo Intermediates in Taurine: α-Ketoglutarate Dioxygenase from Escherichia coli and Its His99Ala Ligand Variant by Sinnecker, Sebastian, Svensen, Nina, Barr, Eric W, Ye, Shengfa, Bollinger, J. Martin, Neese, Frank, Krebs, Carsten

“…The Fe(II)- and α-ketoglutarate (αKG)-dependent dioxygenases activate O2 for cleavage of unactivated C−H bonds in their substrates. The key intermediate that…”
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Manganese(IV)/Iron(III) Cofactor in Chlamydia trachomatis Ribonucleotide Reductase by Jiang, Wei, Yun, Danny, Saleh, Lana, Barr, Eric W, Xing, Gang, Hoffart, Lee M, Maslak, Monique-Anne, Krebs, Carsten, Bollinger, J. Martin Jr

“…In a conventional class I ribonucleotide reductase (RNR), a diiron(II/II) cofactor in the R2 subunit reacts with oxygen to produce a diiron(III/IV)…”
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Osteoactivin Promotes Migration of Oral Squamous Cell Carcinomas by Arosarena, Oneida A., dela Cadena, Raul A., Denny, Michael F., Bryant, Evan, Barr, Eric W., Thorpe, Ryan, Safadi, Fayez F.

“…Nearly 50% of patients with oral squamous cell carcinoma (OSCC) die of metastases or locoregional recurrence. Metastasis is mediated by cancer cell adhesion,…”
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Evidence for Hydrogen Abstraction from C1 of Taurine by the High-Spin Fe(IV) Intermediate Detected during Oxygen Activation by Taurine:α-Ketoglutarate Dioxygenase (TauD) by Price, John C, Barr, Eric W, Glass, Timothy E, Krebs, Carsten, Bollinger, J. Martin

“…The Fe(II)- and α-ketoglutarate-dependent dioxygenases catalyze hydroxylation reactions of considerable biomedical and environmental significance. Recently,…”
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In Vivo Stimulation of α- and β-Adrenoceptors in Mice Differentially Alters Small RNA Content of Circulating Extracellular Vesicles by Kwon, Jin-Sook, Barr, Eric W., Chuprun, J. Kurt, Koch, Walter J.

“…When myocardial function is compromised as in heart failure (HF), there is activation of the sympathetic nervous system with elevated circulating catecholamine…”
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Cryoreduction of the NO-adduct of taurine:alpha-ketoglutarate dioxygenase (TauD) yields an elusive {FeNO}(8) species by Ye, Shengfa, Price, John C, Barr, Eric W, Green, Michael T, Bollinger, Jr, J Martin, Krebs, Carsten, Neese, Frank

“…The Fe(II)- and alpha-ketoglutarate (alphaKG)-dependent enzymes are a functionally and mechanistically diverse group of mononuclear nonheme-iron enzymes that…”
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Spectroscopic Evidence for a High-Spin Br-Fe(IV)-Oxo Intermediate in the α-Ketoglutarate-Dependent Halogenase CytC3 from Streptomyces by Galonić Fujimori, Danica, Barr, Eric W, Matthews, Megan L, Koch, Gretchen M, Yonce, J. Ryan, Walsh, Christopher T, Bollinger, J. Martin, Krebs, Carsten, Riggs-Gelasco, Pamela J

“…The complex of the mononuclear non-heme halogenase CytC3 from Streptomyces, Fe(II), α-ketoglutarate, bromide, and the substrate l-2-aminobutyryl-S-CytC2 reacts…”
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Catalytic site interactions in yeast OMP synthase by Hansen, Michael Riis, Barr, Eric W., Jensen, Kaj Frank, Willemoës, Martin, Grubmeyer, Charles, Winther, Jakob R.

“…•Dimeric yeast OMP synthase binds two molecules of OMP or PRPP per dimer.•Parallel initial velocity plots of WT enzyme become intersecting for K106S…”
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Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3 by Galonić, Danica P, Barr, Eric W, Walsh, Christopher T, Bollinger, J Martin, Krebs, Carsten

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Kinetic Mechanism of Ornithine Hydroxylase (PvdA) from Pseudomonas aeruginosa: Substrate Triggering of O2 Addition but Not Flavin Reduction by Meneely, Kathleen M, Barr, Eric W, Bollinger, J. Martin, Lamb, Audrey L

“…PvdA catalyzes the hydroxylation of the side chain primary amine of ornithine in the initial step of the biosynthesis of the Pseudomonas aeruginosa siderophore…”
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