Search Results - "Baronissi, Giuliana"

Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties by Finamore, Claudia, Baronissi, Giuliana, Marchianò, Silvia, Di Leva, Francesco Saverio, Carino, Adriana, Monti, Maria Chiara, Limongelli, Vittorio, Zampella, Angela, Fiorucci, Stefano, Sepe, Valentina

“…As a cellular bile acid sensor, farnesoid X receptor (FXR) and the membrane G-coupled receptor (GPBAR1) participate in maintaining bile acid, lipid, and…”
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Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G‑Protein-Coupled Bile Acid Receptor 1 by Fiorillo, Bianca, Sepe, Valentina, Conflitti, Paolo, Roselli, Rosalinda, Biagioli, Michele, Marchianò, Silvia, De Luca, Pasquale, Baronissi, Giuliana, Rapacciuolo, Pasquale, Cassiano, Chiara, Catalanotti, Bruno, Zampella, Angela, Limongelli, Vittorio, Fiorucci, Stefano

“…G-protein-coupled receptors (GPCRs) are the molecular target of 40% of marketed drugs and the most investigated structures to develop novel therapeutics…”
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Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury by Sepe, Valentina, Marchianò, Silvia, Finamore, Claudia, Baronissi, Giuliana, Di Leva, Francesco Saverio, Carino, Adriana, Biagioli, Michele, Fiorucci, Chiara, Cassiano, Chiara, Monti, Maria Chiara, del Gaudio, Federica, Novellino, Ettore, Limongelli, Vittorio, Fiorucci, Stefano, Zampella, Angela

“…Acetaminophen misuse is a leading cause of acute liver failure and liver transplantation for which therapy is poorly effective. FXR ligands have shown…”
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