Search Results - "Baron, Bruce M"

CoMFA, Synthesis, and Pharmacological Evaluation of (E)-3-(2-Carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic Acids:  3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic Acid, a Potent Selective Glycine-Site NMDA Receptor Antagonist by Baron, Bruce M, Cregge, Robert J, Farr, Robert A, Friedrich, Dirk, Gross, Raymond S, Harrison, Boyd L, Janowick, David A, Matthews, Donald, McCloskey, Timothy C, Meikrantz, Scott, Nyce, Philip L, Vaz, Roy, Metz, William A

“…(E)-3-(2-Carboxy-2-phenylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acid, 1, is a potent and selective antagonist of the glycine site of the…”
Get full text

A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms by Lovenberg, T W, Baron, B M, de Lecea, L, Miller, J D, Prosser, R A, Rea, M A, Foye, P E, Racke, M, Slone, A L, Siegel, B W

“…We report the cloning and characterization of a novel serotonin receptor, designated as 5-HT7, which is coupled to the stimulation of adenylyl cyclase. 5-HT7…”
Get more information

Binding of 5H-Dibenzo[b,e][1,4]diazepine and Chiral 5H-Dibenzo[a,d]cycloheptene Analogs of Clozapine to Dopamine and Serotonin Receptors by Phillips, Shawn T, de Paulis, Tomas, Baron, Bruce M, Siegel, Barry W, Seeman, Philip, Van Tol, Hubert H. M, Guan, Hong-chang, Smith, Howard E

“…5H-Dibenzo[b,e][1,4]diazepine, dibenz[b,f]oxepin, and 5H-dibenzo[a,d]cycloheptene analogues of clozapine [8-chloro-11-(4-methylpiperazino)-5H-…”
Get full text

Two Members of a Distinct Subfamily of 5-Hydroxytryptamine Receptors Differentially Expressed in Rat Brain by Erlander, Mark G., Lovenberg, Timothy W., Baron, Bruce M., de Lecea, Luis, Danielson, Patria E., Racke, Margaret, Slone, Amy L., Siegel, Barry W., Foye, Pamela E., Cannon, Keith, Burns, Jeffrey E., Sutcliffe, J. Gregor

“…We report two serotonin (5-hydroxytryptamine, 5-HT) receptors, MR22 and REC17, that belong to the G-protein-associated receptor superfamily. MR22 and REC17 are…”
Get full text

Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist by Baron, Bruce M, Harrison, Boyd L, Kehne, John H, Schmidt, Christopher J, Van Giersbergen, Paul L.M, White, H.Steven, Siegel, Barry W, Senyah, Yaw, McCloskey, Timothy C, Fadayel, Gina M, Taylor, Vicki L, Murawsky, Michael K, Nyce, Phillip, Salituro, Francesco G

“…MDL 105,519, ( E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1 H-indole-2-carboxylic acid, is a potent and selective inhibitor of [ 3H]glycine binding to the…”
Get full text

Binding of the radiolabeled glycine site antagonist [ 3H]MDL 105,519 to homomeric NMDA-NR1a receptors by Siegel, Barry W., Sreekrishna, Koti, Baron, Bruce M.

“…We have characterized the binding of [ 3H]MDL 105,519 (( E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1 H-indole-2-carboxylic acid), a NMDA receptor glycine…”
Get full text

Chemical Development of MDL 103371:  An N-Methyl-d-Aspartate-Type Glycine Receptor Antagonist for the Treatment of Stroke by Watson, Timothy J. N, Horgan, Stephen W, Shah, Ramnik S, Farr, Robert A, Schnettler, Richard A, Nevill, C. Richard, Weiberth, Franz J, Huber, Edward W, Baron, Bruce M, Webster, Mark E, Mishra, Rajesh K, Harrison, Boyd L, Nyce, Phillip L, Rand, Cynthia L, Goralski, Christian T

“…MDL 103371 is a N-methyl-d-aspartate (NMDA)-type glycine receptor antagonist for the potential treatment of stroke. Evaluation of five different synthetic…”
Get full text

Development of a prototype reporter-based assay for the evaluation of gap junctional intercellular communication by BARBIER, Ann J, BARON, Bruce M

“…A new reporter-based assay for the evaluation of gap junctional intercellular communication (GJIC) is presented. This assay was applied to the study of…”
Get full text

The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke by Hasegawa, Y, Fisher, M, Baron, B M, Metcalf, G

“…The competitive N-methyl-D-aspartate antagonist MDL-100,453 was used to determine whether a neuroprotective effect is demonstrable when the drug is…”
Get full text

Enzyme-Activated Antagonists of the Strychnine-Insensitive Glycine/NMDA Receptor by Salituro, Francesco G, Tomlinson, Ronald C, Baron, Bruce M, Palfreyman, Michael G, McDonald, Ian A, Schmidt, Werner, Wu, Hui Qiu, Guidetti, Paolo, Schwarcz, Robert

Get full text

Binding of 5H-Dibenzo[a,d]cycloheptene and Dibenz[b,f]oxepin Analogs of Clozapine to Dopamine and Serotonin Receptors by Phillips, Shawn T, de Paulis, Tomas, Neergaard, Jon R, Baron, Bruce M, Siegel, Barry W, Seeman, Philip, Van Tol, Hubert H. M, Guan, Hong-Chang, Smith, Howard E

“…Series of 5,11-dicarbo- and 11-carbo-5-oxy-10-(1-alkyl-1,2,3,6-tetrahydro-4 pyridinyl) analogues and a 11-carbo-5-oxy-10-(1-methyl-4-piperidinyl) analogue of…”
Get full text

2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents by Kane, John M, Baron, Bruce M, Dudley, Mark W, Sorensen, Stephen M, Staeger, Michael A, Miller, Francis P

Get full text

The selectivity of MDL 74,721 in models of neurogenic versus vascular components of migraine by PETTY, M. A, ELANDS, J, JOHNSON, M. P, LINNIK, M. D, HAMEL, E, MOSKOWITZ, M. A, WON SUK LEE, MCCARTY, D. R, HIBERT, M, BARON, B. M

“…MDL 74,721 (R)-2-(N1,N1-dipropylamino)-8-methylaminosulfonylmethyl-1,2,3,4-te trahydronaphthalene, a sulfonamidotetralin, has been found to exhibit a…”
Get full text

4-[(Carboxymethyl)oxy]- and 4-[(carboxymethyl)amino]-5,7-dichloroquinoline-2-carboxylic acid: new antagonists of the strychnine-insensitive glycine binding site on the N-methyl-D-aspartate (NMDA) receptor complex by Harrison, Boyd L, Baron, Bruce M, Cousino, Diane M, McDonald, Ian A

Get full text

(R)-4-Oxo-5-phosphononorvaline: a new competitive glutamate antagonist at the NMDA receptor complex by Whitten, Jeffrey P, Baron, Bruce M, Muench, Daniel, Miller, Francis, White, H. Steven, McDonald, Ian A

Get full text

3-(2-Carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex by Salituro, Francesco G, Harrison, Boyd L, Baron, Bruce M, Nyce, Philip L, Stewart, Kenneth T, McDonald, Ian A

Get full text

3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the NMDA (N-methyl-D-aspartic acid) receptor associated glycine binding site by Salituro, Francesco G, Harrison, Boyd L, Baron, Bruce M, Nyce, Philip L, Stewart, Kenneth T, Kehne, John H, White, H. Steven, McDonald, Ian A

Get full text

Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile by Kehne, J H, Baron, B M, Carr, A A, Chaney, S F, Elands, J, Feldman, D J, Frank, R A, van Giersbergen, P L, McCloskey, T C, Johnson, M P, McCarty, D R, Poirot, M, Senyah, Y, Siegel, B W, Widmaier, C

“…In preclinical studies, [R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4- piperidinemethanol] [formula: see text] (MDL 100,907), a putative…”
Get more information

CoMFA, Synthesis, and Pharmacological Evaluation of ( E )-3-(2-Carboxy-2-arylvinyl)-4,6-dichloro-1 H -indole-2-carboxylic Acids:  3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1 H -indole-2-carboxylic Acid, a Potent Selective Glycine-Site NMDA Receptor Antagonist by Baron, Bruce M., Cregge, Robert J., Farr, Robert A., Friedrich, Dirk, Gross, Raymond S., Harrison, Boyd L., Janowick, David A., Matthews, Donald, McCloskey, Timothy C., Meikrantz, Scott, Nyce, Philip L., Vaz, Roy, Metz, William A.

Get full text

CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonis by BARON, Bruce M, CREGGE, Robert J, NYCE, Philip L, VAZ, Roy, METZ, William A, FARR, Robert A, FRIEDRICH, Dirk, GROSS, Raymond S, HARRISON, Boyd L, JANOWICK, David A, MATTHEWS, Donald, MCCLOSKEY, Timothy C, MEIKRANTZ, Scott

Get full text