Search Results - "Baron, Alain D"

Leptin responsiveness restored by amylin agonism in diet-induced obesity: Evidence from nonclinical and clinical studies by Roth, Jonathan D, Roland, Barbara L, Cole, Rebecca L, Trevaskis, James L, Weyer, Christian, Koda, Joy E, Anderson, Christen M, Parkes, David G, Baron, Alain D

“…Body weight is regulated by complex neurohormonal interactions between endocrine signals of long-term adiposity (e.g., leptin, a hypothalamic signal) and…”
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Effects of Exenatide (Exendin-4) on Glycemic Control and Weight Over 30 Weeks in Metformin-Treated Patients With Type 2 Diabetes by DeFronzo, Ralph A, Ratner, Robert E, Han, Jenny, Kim, Dennis D, Fineman, Mark S, Baron, Alain D

“…OBJECTIVE:--This study evaluates the ability of the incretin mimetic exenatide (exendin-4) to improve glycemic control in patients with type 2 diabetes failing…”
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Effects of Exenatide (Exendin-4) on Glycemic Control Over 30 Weeks in Patients With Type 2 Diabetes Treated With Metformin and a Sulfonylurea by Kendall, David M, Riddle, Matthew C, Rosenstock, Julio, Zhuang, Dongliang, Kim, Dennis D, Fineman, Mark S, Baron, Alain D

“…OBJECTIVE:--This study evaluated the effects of exenatide, a novel incretin mimetic, in hyperglycemic patients with type 2 diabetes unable to achieve glycemic…”
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Effects of Exenatide (Exendin-4) on Glycemic Control Over 30 Weeks in Sulfonylurea-Treated Patients With Type 2 Diabetes by BUSE, John B, HENRY, Robert R, HAN, Jenny, KIM, Dennis D, FINEMAN, Mark S, BARON, Alain D

“…Effects of Exenatide (Exendin-4) on Glycemic Control Over 30 Weeks in Sulfonylurea-Treated Patients With Type 2 Diabetes John B. Buse , MD, PHD 1 , Robert R…”
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Amylin-Mediated Restoration of Leptin Responsiveness in Diet-Induced Obesity: Magnitude and Mechanisms by Trevaskis, James L, Coffey, Todd, Cole, Rebecca, Lei, Chunli, Wittmer, Carrie, Walsh, Brandon, Weyer, Christian, Koda, Joy, Baron, Alain D, Parkes, David G, Roth, Jonathan D

“…Previously, we reported that combination treatment with rat amylin (100 μg/kg·d) and murine leptin (500 μg/kg·d) elicited greater inhibition of food intake and…”
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Endothelin Limits Insulin Action in Obese/Insulin-Resistant Humans by LTEIF, Amale, VAISHNAVA, Prashant, BARON, Alain D, MATHER, Kieren J

“…Endothelin Limits Insulin Action in Obese/Insulin-Resistant Humans Amale Lteif 1 , Prashant Vaishnava 2 , Alain D. Baron 1 3 and Kieren J. Mather 1 1 Division…”
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Effect on Glycemic Control of Exenatide (Synthetic Exendin-4) Additive to Existing Metformin and/or Sulfonylurea Treatment in Patients With Type 2 Diabetes by FINEMAN, Mark S, BICSAK, Thomas A, SHEN, Larry Z, TAYLOR, Kristin, GAINES, Eling, VARNS, Amanda, KIM, Dennis, BARON, Alain D

“…Effect on Glycemic Control of Exenatide (Synthetic Exendin-4) Additive to Existing Metformin and/or Sulfonylurea Treatment in Patients With Type 2 Diabetes…”
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The exenatide analogue AC3174 attenuates hypertension, insulin resistance, and renal dysfunction in Dahl salt-sensitive rats by Liu, Que, Adams, Lisa, Broyde, Anatoly, Fernandez, Rayne, Baron, Alain D, Parkes, David G

“…Activation of glucagon-like peptide-1 (GLP-1) receptors improves insulin sensitivity and induces vasodilatation and diuresis. AC3174 is a peptide analogue with…”
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Interactions Between Endothelin and Nitric Oxide in the Regulation of Vascular Tone in Obesity and Diabetes by MATHER, Kieren J, LTEIF, Amale, STEINBERG, Helmut O, BARON, Alain D

“…Interactions Between Endothelin and Nitric Oxide in the Regulation of Vascular Tone in Obesity and Diabetes Kieren J. Mather 1 , Amale Lteif 1 , Helmut O…”
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Endothelin Contributes to Basal Vascular Tone and Endothelial Dysfunction in Human Obesity and Type 2 Diabetes by MATHER, Kieren J, MIRZAMOHAMMADI, Bahram, LTEIF, Amale, STEINBERG, Helmut O, BARON, Alain D

“…Endothelin Contributes to Basal Vascular Tone and Endothelial Dysfunction in Human Obesity and Type 2 Diabetes Kieren J. Mather 1 , Bahram Mirzamohammadi 1 ,…”
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Type II diabetes abrogates sex differences in endothelial function in premenopausal women by STEINBERG, H. O, PARADISI, G, CRONIN, J, CROWDE, K, HEMPFLING, A, HOOK, G, BARON, A. D

“…Obesity is a more potent cardiovascular risk factor (CVRF) in men than in women. Because traditional CVRFs cannot fully account for this sex difference, we…”
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Insulin resistance in the vasculature by Mather, Kieren J, Steinberg, Helmut O, Baron, Alain D

“…Insulin resistance is typically defined as a reduced ability of insulin to induce glucose uptake by target tissues such as fat and skeletal muscle cells. It…”
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Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans by Katz, Arie, Nambi, Sridhar S., Mather, Kieren, Baron, Alain D., Follmann, Dean A., Sullivan, Gail, Quon, Michael J.

“…Insulin resistance plays an important role in the pathophysiology of diabetes and is associated with obesity and other cardiovascular risk factors. The “gold…”
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Antiobesity Effects of the β-Cell Hormone Amylin in Diet-Induced Obese Rats: Effects on Food Intake, Body Weight, Composition, Energy Expenditure, and Gene Expression by Roth, Jonathan D, Hughes, Heather, Kendall, Eric, Baron, Alain D, Anderson, Christen M

“…Effects of amylin and pair feeding (PF) on body weight and metabolic parameters were characterized in diet-induced obesity-prone rats. Peripherally…”
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Insulin and Endothelin in the Acute Regulation of Adiponectin in Vivo in Humans by Brame, Lori A, Considine, Robert V, Yamauchi, Mikako, Baron, Alain D, Mather, Kieren J

“…OBJECTIVE: In vitro, insulin and endothelin (ET) both modulate adiponectin secretion from adipocyte cell lines. The current studies were performed to assess…”
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Synthetic Exendin-4 (Exenatide) Significantly Reduces Postprandial and Fasting Plasma Glucose in Subjects with Type 2 Diabetes by Kolterman, Orville G., Buse, John B., Fineman, Mark S., Gaines, Eling, Heintz, Sonja, Bicsak, Thomas A., Taylor, Kristin, Kim, Dennis, Aisporna, Maria, Wang, Yan, Baron, Alain D.

“…Despite the advent of new treatments, glucose control in the type 2 diabetes population is unsatisfactory. AC2993 (synthetic exendin-4; exenatide), a novel…”
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Exenatide (Exendin-4) Improves Insulin Sensitivity and β-Cell Mass in Insulin-Resistant Obese fa/fa Zucker Rats Independent of Glycemia and Body Weight by Gedulin, Bronislava R, Nikoulina, Svetlana E, Smith, Pamela A, Gedulin, George, Nielsen, Loretta L, Baron, Alain D, Parkes, David G, Young, Andrew A

“…The effects of the incretin mimetic exenatide (exendin-4) on metabolic parameters, insulin sensitivity, and β-cell mass were examined in nondiabetic,…”
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Insulin resistance and vascular function by Baron, Alain D.

“…It has become clear that amongst its many actions insulin is also a vasoactive hormone. Its effect to cause endothelial-nitric oxide-dependent vasodilation is…”
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Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus by Kolterman, Orville G, Kim, Dennis D, Shen, Larry, Ruggles, James A, Nielsen, Loretta L, Fineman, Mark S, Baron, Alain D

“…The pharmacology and tolerability of exenatide in patients with type 2 diabetes mellitus were studied. Two randomized, single-blind, placebo-controlled studies…”
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Polycystic ovary syndrome is associated with endothelial dysfunction by PARADISI, Giancarlo, STEINBERG, Helmut O, HEMPFLING, Annette, CRONIN, Jessica, HOOK, Ginger, SHEPARD, Marguerite K, BARON, Alain D

“…We recently reported endothelial dysfunction as a novel cardiovascular risk factor associated with insulin resistance/obesity. Here, we tested whether…”
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