Search Results - "Barnhart, Richard W."

Exploratory Process Development of Lorlatinib by Li, Bryan, Barnhart, Richard W, Hoffman, Jacqui E, Nematalla, Asaad, Raggon, Jeffrey, Richardson, Paul, Sach, Neal, Weaver, John

“…The original synthesis of lorlatinib (1) was applied and improved in the first GMP campaign. In this approach, a slow addition of the boronate ester was…”
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Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors by Li, Bryan, Barnhart, Richard W, Dion, Amelie, Guinness, Steven, Happe, Alan, Hayward, Cheryl M, Kohrt, Jeffrey, Makowski, Teresa, Maloney, Mark, Nelson, Jade D, Nematalla, Asaad, McWilliams, J. Christopher, Peng, Zhihui, Raggon, Jeffrey, Sagal, John, Weisenburger, Gerald A, Bao, Denghui, Gonzalez, Miguel, Lu, Jiangping, McLaws, Mark D, Tao, Jian, Wu, Baolin

“…Process development for the synthesis of a second generation β-amyloid-cleaving enzyme (BACE1) inhibitor (1) is described. The lithiothiazole addition to the…”
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Asymmetric Catalysis. Asymmetric Catalytic Intramolecular Hydroacylation of 4-Pentenals Using Chiral Rhodium Diphosphine Catalysts by Barnhart, Richard W, Wang, Xianqi, Noheda, Pedro, Bergens, Steven H, Whelan, John, Bosnich, B

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Safety Notables: Information from the Literature by Barnhart, Richard W, Dale, David, Ironside, Michael D, Shaw, Stephen M

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Homogeneous Catalysis. Mechanism of Diastereoselective Hydroacylation of 3-Substituted-4-pentenals using Chiral Rhodium Catalysts by Barnhart, Richard W, Bosnich, B

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Safety Notables: Information from the Literature by Barnhart, Richard W, Dale, David, Ironside, Michael D, Shaw, Stephen M

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Synthesis of Branched Polyolefins Using a Combination of Homogeneous Metallocene Mimics by Barnhart, Richard W, Bazan, Guillermo C, Mourey, Thomas

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Measurement of Gas Flow Rates from Small-Scale Reactions by Weisenburger, Gerald A, Barnhart, Richard W, Steeno, Gregory S

“…The rate and total volume of noncondensable gas generation are important parameters in the safe, successful scale-up of chemical processes. Information…”
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Safety Notables: Information from the Literature by Barnhart, Richard W, Dale, David J, Ironside, Michael D, Vogt, Paul F

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Decomposition of energetic chemicals contaminated with iron or stainless steel by Chervin, Sima, Bodman, Glenn T., Barnhart, Richard W.

“…Contamination of chemicals or reaction mixtures with iron or stainless steel is likely to take place during chemical processing. If energetic and thermally…”
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Determination of Reaction Heat: A Comparison of Measurement and Estimation Techniques by Weisenburger, Gerald A, Barnhart, Richard W, Clark, Jerry D, Dale, David J, Hawksworth, Mike, Higginson, Paul D, Kang, Ying, Knoechel, Donald J, Moon, Brian S, Shaw, Stephen M, Taber, Geraldine P, Tickner, Derek L

“…The heat of reaction is an important parameter in the safe, successful scale-up of chemical processes. Reaction heat data is used to calculate the potential…”
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Process Development of a Triphasic Continuous Flow Suzuki–Miyaura Coupling Reaction in a Plug Flow Reactor by Li, Bryan, Barnhart, Richard W., Fung, Peter, Hayward, Cheryl, Heid, Richard, Houck, Timothy, Liu, Weiguo, Samp, Lacey, Sutherland, Karen, Van Alsten, John, Varsolona, Richard, Zeldis, Joseph

“…We have successfully adapted a Suzuki–Miyaura coupling reaction to a continuous flow process. The reaction was a triphasic mixture involved with two liquid…”
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Early Process Development of PF-07054894, a Squaramide-Based Antagonist of C–C Chemokine Receptor Type 6 (CCR6) by Chinigo, Gary M., McInturff, Emma L., Bagley, Scott W., Barnhart, Richard W., Blakemore, David C., Han, Lu, Lee, Taegyo, Magano, Javier, McWilliams, J. Christopher, Monfette, Sebastien, Mousseau, James J., Pan, Senliang, Pedro, Dylan, Perfect, Hahdi H., Raggon, Jeffrey W., Rose, Peter R., Sagal, John, Trujillo, John I., Van Haitsma, Jared, Vetelino, Michael G., Yang, Xiaojing Helen

“…The original synthesis of a CCR6 antagonist and subsequent enablement for kilogram manufacture is presented. Highlighted improvements made in the preparation…”
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Enantioselective catalytic intramolecular hydroacylation by Barnhart, Richard W., McMorran, David A., Bosnich, B.

“…Catalysts of the type [Rh(diphosphine)] + catalyze intramolecular cyclization of 4-pentenals to cyclopentanones. By using chiral diphosphines, 4-substituted…”
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