Search Results - "Barnette, M S"

Suppression of human inflammatory cell function by subtype‐selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B by Manning, Carol D, Burman, Miriam, Christensen, Siegfried B, Cieslinski, Lenora B, Essayan, David M, Grous, Marilyn, Torphy, Theodore J, Barnette, Mary S

“…Of the four major phosphodiesterase 4 (PDE4) subtypes, PDE4A, PDE4B and PDE4D are widely expressed in human inflammatory cells, including monocytes and T…”
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Inhibitors of phosphodiesterase IV (PDE IV) increase acid secretion in rabbit isolated gastric glands: correlation between function and interaction with a high-affinity rolipram binding site by Barnette, M S, Grous, M, Cieslinski, L B, Burman, M, Christensen, S B, Torphy, T J

“…In this report, we describe the ability of selective inhibitors of phosphodiesterase (PDE) isozymes to increase aminopyrine accumulation in rabbit isolated…”
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Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic by Torphy, T J, Barnette, M S, Underwood, D C, Griswold, D E, Christensen, S B, Murdoch, R D, Nieman, R B, Compton, C H

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Expression and Cellular Localization of the CC Chemokines PARC and ELC in Human Atherosclerotic Plaques by Reape, Theresa J., Rayner, Kim, Manning, Carol D., Gee, Andrew N., Barnette, Mary S., Burnand, Kevin G., Groot, Pieter H.E.

“…Local immune responses are thought to play an important role in the development of atherosclerosis. Histological studies have shown that human atherosclerotic…”
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The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity by Barnette, M S, Manning, C D, Cieslinski, L B, Burman, M, Christensen, S B, Torphy, T J

“…Elevation of cyclic AMP (cAMP) content inhibits eosinophil function. Because phosphodiesterase IV (PDE IV) appears to be the major PDE isozyme present in…”
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Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [ 3H]rolipram binding by Bamette, Mary S., Bartus, Joan O'Leary, Burman, Miriam, Christensen, Siegfried B., Cieslinski, Lenora B., Esser, Klaus M., Prabhakar, Uma S., Rush, Julia A., Torphy, Theodore J.

“…Phosphodiesterase 4 (PDE4) inhibitors are novel anti-inflammatory compounds. Unfortunately, the archetypal PDE4 inhibitor rolipram produces central nervous…”
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Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B by Manning, C D, McLaughlin, M M, Livi, G P, Cieslinski, L B, Torphy, T J, Barnette, M S

“…Human peripheral blood monocytes were treated for 4 h with a combination of the beta-agonist salbutamol (3 microM) and the low-Km cAMP-specific…”
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Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD) by Barnette, M S

“…Phosphodiesterases (PDE) are a family of enzymes responsible for the metabolism of the intracellular second messengers cyclic AMP and cyclic GMP. PDE4 is a…”
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Initial biochemical and functional characterization of cyclic nucleotide phosphodiesterase isozymes in canine colonic smooth muscle by Barnette, M S, Manning, C D, Price, W J, Barone, F C

“…Cyclic nucleotides mediate relaxation of gastrointestinal smooth muscle. The intracellular concentration of these second messengers is determined by a balance…”
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Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes by Smith, Susan J, Cieslinski, Lenora B, Newton, Robert, Donnelly, Louise E, Fenwick, Peter S, Nicholson, Andrew G, Barnes, Peter J, Barnette, Mary S, Giembycz, Mark A

“…The biochemical and pharmacological characteristics in human proinflammatory cells of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a novel…”
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Characterization of the antigen-induced contraction of colonic smooth muscle from sensitized guinea pigs by Barnette, M S, Grous, M

“…To study the potential of inflammatory mediators to alter colonic motility, we characterized the response of distal colonic smooth muscle to antigen challenge…”
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Activation of cyclic AMP-dependent protein kinase during canine lower esophageal sphincter relaxation by Barnette, M S, Grous, M, Torphy, T J, Ormsbee, 3rd, H S

“…In isolated strips of opossum lower esophageal sphincter (LES) smooth muscle, elevation of cyclic AMP (cAMP) content is associated with relaxation. Because the…”
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SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions by Barnette, M S, Christensen, S B, Essayan, D M, Grous, M, Prabhakar, U, Rush, J A, Kagey-Sobotka, A, Torphy, T J

“…First-generation phosphodiesterase 4 (PDE4) inhibitors, such as rolipram, inhibit the activation of immune and inflammatory cells. The clinical use of these…”
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Lower esophageal sphincter relaxation is associated with increased cyclic nucleotide content by Torphy, T J, Fine, C F, Burman, M, Barnette, M S, Ormsbee, 3rd, H S

“…Experiments were conducted to determine whether relaxation of the opossum isolated lower esophageal sphincter (LES), induced by electrical field stimulation…”
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Human lower oesophageal sphincter relaxation is associated with raised cyclic nucleotide content by Barnette, M S, Barone, F C, Fowler, P J, Grous, M, Price, W J, Ormsbee, H S

“…Increases in cyclic adenosine monophosphate and cyclic guanosine monophosphate content accompany relaxation of isolated strips of opossum and canine lower…”
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Inhibition of calmodulin activity by insect venom peptides by Barnette, M S, Daly, R, Weiss, B

“…Several peptides found in insect venom, including melittin, apamin and mastoparan, inhibited the activity of calmodulin-stimulated phosphodiesterase at…”
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Inhibition of neuronally induced relaxation of canine lower esophageal sphincter by opioid peptides by Barnette, M S, Grous, M, Manning, C D, Callahan, J F, Barone, F C

“…Opioid peptides have profound effects on gut motility. To assess their actions on enteric neurons regulating sphincteric smooth muscle, the ability of several…”
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Phosphodiesterase IV Inhibitors as Therapy for Eosinophil-Induced Lung Injury in Asthma by Torphy, Theodore J., Barnette, Mary S., Douglas W. P. Hay, Underwood, David C.

“…Asthma is a complex, multifactorial disease that is underpinned by airway inflammation. A variety of cytotoxic substances are released into the airway from…”
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Inhibition of calmodulin-stimulated phosphodiesterase activity by vasoactive intestinal peptide by Barnette, M S, Weiss, B

“…The effects of certain peptides of the glucagon family on calmodulin activity were determined from their capacity to inhibit a calmodulin-dependent form of…”
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Cyclic nucleotide-dependent protein kinases in the lower esophageal sphincter by Miller, C A, Barnette, M S, Ormsbee, 3rd, H S, Torphy, T J

“…The characteristics and regulation of adenosine 3',5'-cyclic monophosphate (cAMP)-dependent and guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein…”
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