Search Results - "Barnette, Dustyn A"

Machine learning liver-injuring drug interactions with non-steroidal anti-inflammatory drugs (NSAIDs) from a retrospective electronic health record (EHR) cohort by Datta, Arghya, Flynn, Noah R., Barnette, Dustyn A., Woeltje, Keith F., Miller, Grover P., Swamidass, S. Joshua

“…Drug-drug interactions account for up to 30% of adverse drug reactions. Increasing prevalence of electronic health records (EHRs) offers a unique opportunity…”
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Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches by Barnette, Dustyn A., Davis, Mary A., Dang, Na L., Pidugu, Anirudh S., Hughes, Tyler, Swamidass, S. Joshua, Boysen, Gunnar, Miller, Grover P.

“…[Display omitted] Lamisil (terbinafine) may cause idiosyncratic liver toxicity through a proposed toxicological mechanism involving the reactive metabolite…”
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CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches by Davis, Mary A, Barnette, Dustyn A, Flynn, Noah R, Pidugu, Anirudh S, Swamidass, S. Joshua, Boysen, Gunnar, Miller, Grover P

“…Lamisil (terbinafine) is an effective, widely prescribed antifungal drug that causes rare idiosyncratic hepatotoxicity. The proposed toxic mechanism involves a…”
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Discovery of Novel Reductive Elimination Pathway for 10-Hydroxywarfarin by Pouncey, Dakota L, Barnette, Dustyn A, Sinnott, Riley W, Phillips, Sarah J, Flynn, Noah R, Hendrickson, Howard P, Swamidass, S Joshua, Miller, Grover P

“…Coumadin (R/S-warfarin) anticoagulant therapy is highly efficacious in preventing the formation of blood clots; however, significant inter-individual…”
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Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam by Barnette, Dustyn A., Schleiff, Mary A., Datta, Arghya, Flynn, Noah, Swamidass, S. Joshua, Miller, Grover P.

“…[Display omitted] •Quantitative kinetics revealed enzyme roles in meloxicam/sudoxicam metabolism.•Thiazole methyl substituent alters enzyme specificity for…”
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Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam by Barnette, Dustyn A., Schleiff, Mary A., Osborn, Laura R., Flynn, Noah, Matlock, Matthew, Swamidass, S. Joshua, Miller, Grover P.

“…[Display omitted] •Electron density increased modeled epoxidations but depended on substituent types.•Novel kinetics showed impact of thiazole methyl on…”
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Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation by Barnette, Dustyn A., Davis, Mary A., Flynn, Noah, Pidugu, Anirudh S., Swamidass, S. Joshua, Miller, Grover P.

“…[Display omitted] Terbinafine N-dealkylation pathways result in formation of 6,6-dimethyl-2-hepten-4-ynal (TBF-A), a reactive allylic aldehyde, that may…”
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Stereospecific Metabolism of R - and S -Warfarin by Human Hepatic Cytosolic Reductases by Barnette, Dustyn A, Johnson, Bryce P, Pouncey, Dakota L, Nshimiyimana, Robert, Desrochers, Linda P, Goodwin, Thomas E, Miller, Grover P

“…Coumadin (rac-warfarin) is the most commonly used anticoagulant in the world; however, its clinical use is often challenging because of its narrow therapeutic…”
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Machine learning liver-injuring drug interactions with non-steroidal anti-inflammatory drugs cohort by Datta, Arghya, Flynn, Noah R, Barnette, Dustyn A, Woeltje, Keith F, Miller, Grover P, Swamidass, S. Joshua

“…Drug-drug interactions account for up to 30% of adverse drug reactions. Increasing prevalence of electronic health records (EHRs) offers a unique opportunity…”
Get full text

Machine learning liver-injuring drug interactions with non-steroidal anti-inflammatory drugs by Datta, Arghya, Flynn, Noah R, Barnette, Dustyn A, Woeltje, Keith F, Miller, Grover P, Swamidass, S. Joshua

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Modeling the Metabolism and Subsequent Reactivity of Drugs by Swamidass, S. Joshua, Matlock, Matthew, Le Dang, Na, Hughes, Tyler, Barnette, Dustyn A, Miller, Grover P.

“…Abstract only Adverse drug reactions (ADRs) are dangerous and expensive. Idiosyncratic ADRs, especially the difficult to predict, rare and severe…”
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