Search Results - "Barnetson, Rebecca A"

Effect of aspirin and NSAIDs on risk and survival from colorectal cancer by Din, Farhat V N, Theodoratou, Evropi, Farrington, Susan M, Tenesa, Albert, Barnetson, Rebecca A, Cetnarskyj, Roseanne, Stark, Lesley, Porteous, Mary E, Campbell, Harry, Dunlop, Malcolm G

“…Previous studies have shown that aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) lower colorectal cancer (CRC) risk. However, the lowest…”
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Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 by Houlston, Richard S, Dunlop, Malcolm G, Tomlinson, Ian P M, Cheadle, Jeremy, Dobbins, Sara E, Tenesa, Albert, Jones, Angela M, Howarth, Kimberley, Spain, Sarah L, Broderick, Peter, Domingo, Enric, Farrington, Susan, Prendergast, James G D, Pittman, Alan M, Theodoratou, Evi, Smith, Christopher G, Olver, Bianca, Walther, Axel, Barnetson, Rebecca A, Churchman, Michael, Jaeger, Emma E M, Penegar, Steven, Barclay, Ella, Martin, Lynn, Gorman, Maggie, Mager, Rachel, Johnstone, Elaine, Midgley, Rachel, Niittymäki, Iina, Tuupanen, Sari, Colley, James, Idziaszczyk, Shelley, Thomas, Huw J W, Lucassen, Anneke M, Evans, D Gareth R, Maher, Eamonn R, Maughan, Timothy, Dimas, Antigone, Dermitzakis, Emmanouil, Cazier, Jean-Baptiste, Aaltonen, Lauri A, Pharoah, Paul, Kerr, David J, Carvajal-Carmona, Luis G, Campbell, Harry

“…Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance…”
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Identification and Survival of Carriers of Mutations in DNA Mismatch-Repair Genes in Colon Cancer by Barnetson, Rebecca A, Tenesa, Albert, Farrington, Susan M, Nicholl, Iain D, Cetnarskyj, Roseanne, Porteous, Mary E, Campbell, Harry, Dunlop, Malcolm G

“…A group of 870 consecutive patients with colorectal cancer were tested for germ-line mutations in DNA repair genes. A two-stage model was devised to predict…”
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Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 by Farrington, Susan M, Schmidt, Carsten O, Kustra, Rafal, Chang-Claude, Jenny, Carvajal-Carmona, Luis, Cetnarskyj, Roseanne, Broderick, Peter, Wilkening, Stefan, Webb, Emily, Kidokoro, Tomohide, Montpetit, Alexandre, Tenesa, Albert, Ballinger, Dennis, Brenner, Hermann, Moreno, Victor, Tepel, Jürgen, Rozek, Laura, Porteous, Mary E, Gallinger, Steven, Starr, John M, Nakamura, Yusuke, Buch, Stephan, Hampe, Jochen, Hoffmeister, Michael, Matsuda, Koichi, Reid, Fiona J L, Haq, Naila, Pharoah, Paul D P, Canzian, Federico, Tomlinson, Ian P M, Vijayakrishnan, Jayaram, Houlston, Richard S, Hudson, Thomas J, Deary, Ian J, Barnetson, Rebecca A, Kavoussanakis, Kostas, Semple, Colin, Cartwright, Nicola, Gruber, Stephen B, Dunlop, Malcolm G, Koessler, Thibaud, Prendergast, James G D, Rangrej, Jagadish, Clark, Andrew J, Schafmayer, Clemens, Campbell, Harry, Howarth, Kimberley, Capella, Gabriel, Völzke, Henry, Rennert, Gad, Smith, Lorna A, Zanke, Brent W, Greenwood, Celia M T, Kemp, Zoe, Schreiber, Stefan, Walker, Marion, Theodoratou, Evropi

“…In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC…”
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Risks of Lynch Syndrome Cancers for MSH6 Mutation Carriers by Baglietto, Laura, Lindor, Noralane M., Dowty, James G., White, Darren M., Wagner, Anja, Gomez Garcia, Encarna B., Vriends, Annette H. J. T., Cartwright, Nicola R., Barnetson, Rebecca A., Farrington, Susan M., Tenesa, Albert, Hampel, Heather, Buchanan, Daniel, Arnold, Sven, Young, Joanne, Walsh, Michael D., Jass, Jeremy, Macrae, Finlay, Antill, Yoland, Winship, Ingrid M., Giles, Graham G., Goldblatt, Jack, Parry, Susan, Suthers, Graeme, Leggett, Barbara, Butz, Malinda, Aronson, Melyssa, Poynter, Jenny N., Baron, John A., Le Marchand, Loic, Haile, Robert, Gallinger, Steve, Hopper, John L., Potter, John, de la Chapelle, Albert, Vasen, Hans F., Dunlop, Malcolm G., Thibodeau, Stephen N., Jenkins, Mark A.

“…Background Germline mutations in MSH6 account for 10%–20% of Lynch syndrome colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because…”
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Dietary Vitamin B6 Intake and the Risk of Colorectal Cancer by THEODORATOU, Evropi, FARRINGTON, Susan M, TENESA, Albert, MCNEILL, Geraldine, CETNARSKYJ, Roseanne, BARNETSON, Rebecca A, PORTEOUS, Mary E, DUNLOP, Malcolm G, CAMPBELL, Harry

“…Vitamin B6, a coenzyme in the folate metabolism pathway, may have anticarcinogenic effects. Laboratory and epidemiologic studies support the hypothesis of its…”
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Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding by Theodoratou, Evropi, Farrington, Susan M., Tenesa, Albert, McNeill, Geraldine, Cetnarskyj, Roseanne, Barnetson, Rebecca A., Porteous, Mary E., Dunlop, Malcolm G., Campbell, Harry

“…Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms…”
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Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants by Theodoratou, Evropi, Campbell, Harry, Tenesa, Albert, McNeill, Geraldine, Cetnarskyj, Roseanne, Barnetson, Rebecca A., Porteous, Mary E., Dunlop, Malcolm G., Farrington, Susan M.

“…In a large Scottish case–control study, we investigated the effects of adenomatous polyposis coli (APC) Asp1822Val (rs459552) and APC Glu1317Gln substitutions…”
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A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 by Koessler, Thibaud, Chandler, Ian, Buch, Stephan, Agúndez, Jose AG, Caldés, Trinidad, Howarth, Kimberley, Walther, Axel, Ladero, Jose M, Morreau, Hans, Giles, Graham G, Cazier, Jean-Baptiste, Castells, Antoni, Maher, Eamonn R, Wood, Wendy, Försti, Asta, Southey, Melissa C, Broderick, Peter, Hopper, John L, de la Hoya, Miguel, Webb, Emily, Wijnen, Juul T, Aaltonen, Lauri, Dunlop, Malcolm G, John, Ulrich, Fielding, Sarah, Barnetson, Rebecca A, Barclay, Ella, Martin, Lynn, Bishop, D Timothy, Tuupanen, Sari, Tenesa, Albert, Jaeger, Emma, Cheng, K K, Niittymäki, Iina, Karhu, Auli, Schreiber, Stefan, Peto, Julian, Völzke, Henry, Schafmayer, Clemens, Luk, J, Vodicka, Pavel, Vijayakrishnan, Jayaram, Carracedo, Angel, Houlston, Richard S, Tomlinson, Ian PM, Rowan, Andrew, Ruiz-Ponte, Clara, Ho, Judy WC, Kemp, Zoe, Lipton, Lara, Sullivan, Kate, Penegar, Steven, Prendergast, James GD, Carvajal-Carmona, Luis, Hampe, Jochen, Sham, Pak C, Kerr, David, Pharoah, Paul, Severi, Gianluca, Campbell, Harry, Pittman, Alan M, Gray, Richard, Castellví-Bel, Sergi, Spain, Sarah, Domingo, Enric, Hemminki, Kari, Lubbe, Steven, Thomas, Huw, van Wezel, Tom, Naccarati, Alessio, Gorman, Maggie, Lucassen, Anneke, Farrington, Susan M, Qureshi, Mobshra, Evans, D Gareth R

“…To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940…”
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Classification of ambiguous mutations in DNA mismatch repair genes identified in a population-based study of colorectal cancer by Barnetson, Rebecca A, Cartwright, Nicola, van Vliet, Annelot, Haq, Naila, Drew, Kate, Farrington, Susan, Williams, Nicola, Warner, Jon, Campbell, Harry, Porteous, Mary E, Dunlop, Malcolm G

“…Identification of germline mutations in DNA mismatch repair genes in colorectal cancer probands without an extensive family history can be problematic when…”
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Unusual presentation of Lynch Syndrome by Yu, Veronica P C C, Novelli, Marco, Payne, Stewart J, Fisher, Sam, Barnetson, Rebecca A, Frayling, Ian M, Barrett, Ann, Goudie, David, Ardern-Jones, Audrey, Eeles, Ros, Shanley, Susan

“…Lynch Syndrome/HNPCC is a syndrome of cancer predisposition linked to inherited mutations of genes participating in post-replicative DNA mismatch repair (MMR)…”
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Ten Common Genetic Variants Associated with Colorectal Cancer Risk Are Not Associated with Survival after Diagnosis by TENESA, Albert, THEODORATOU, Evropi, DIN, Farhat V. N, FARRINGTON, Susan M, CETNARSKYJ, Roseanne, BARNETSON, Rebecca A, PORTEOUS, Mary E, CAMPBELL, Harry, DUNLOP, Malcolm G

“…To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci…”
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Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types by Ewart-Toland, Amanda, Dai, Qi, Gao, Yu-Tang, Nagase, Hiroki, Dunlop, Malcolm G., Farrington, Susan M., Barnetson, Rebecca A., Anton-Culver, Hoda, Peel, David, Ziogas, Argyrios, Lin, Dongxin, Miao, Xiaoping, Sun, Tong, Ostrander, Elaine A., Stanford, Janet L., Langlois, Mariela, Chan, June M., Yuan, Jinwei, Harris, Curtis C., Bowman, Elise D., Clayman, Gary L., Lippman, Scott M., Lee, J. Jack, Zheng, Wei, Balmain, Allan

“…STK15 (Aurora-A) is a serine/threonine kinase involved in mitotic chromosomal segregation. A genetic variant in STK15 T+91A (resulting in the amino acid…”
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Association between common mtDNA variants and all-cause or colorectal cancer mortality by Theodoratou, Evropi, Din, Farhat V.N., Farrington, Susan M., Cetnarskyj, Roseanne, Barnetson, Rebecca A., Porteous, Mary E., Dunlop, Malcolm G., Campbell, Harry, Tenesa, Albert

“…Mutations in the mitochondrial DNA (mtDNA) have been found to be present in several types of tumours including tumours of the large bowel. However, their role…”
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Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer by Houlston, Richard S, Webb, Emily, Broderick, Peter, Pittman, Alan M, Di Bernardo, Maria Chiara, Lubbe, Steven, Chandler, Ian, Vijayakrishnan, Jayaram, Sullivan, Kate, Penegar, Steven, Carvajal-Carmona, Luis, Howarth, Kimberley, Jaeger, Emma, Spain, Sarah L, Walther, Axel, Barclay, Ella, Martin, Lynn, Gorman, Maggie, Domingo, Enric, Teixeira, Ana S, Kerr, David, Cazier, Jean-Baptiste, Niittymäki, Iina, Tuupanen, Sari, Karhu, Auli, Aaltonen, Lauri A, Tomlinson, Ian P M, Farrington, Susan M, Tenesa, Albert, Prendergast, James G D, Barnetson, Rebecca A, Cetnarskyj, Roseanne, Porteous, Mary E, Pharoah, Paul D P, Koessler, Thibaud, Hampe, Jochen, Buch, Stephan, Schafmayer, Clemens, Tepel, Jurgen, Schreiber, Stefan, Völzke, Henry, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Zanke, Brent W, Montpetit, Alexandre, Hudson, Thomas J, Gallinger, Steven, Campbell, Harry, Dunlop, Malcolm G

“…Richard Houlston and colleagues identify four new susceptibility loci for colorectal cancer through a meta-analysis of genome-wide association data, followed…”
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Germline mutation prevalence in the base excision repair gene, MYH, in patients with endometrial cancer by Barnetson, RA, Devlin, L, Miller, J, Farrington, SM, Slater, S, Drake, AC, Campbell, H, Dunlop, MG, Porteous, ME

“…Germline mutations in the base excision repair gene, MutY human homolog (MYH), have recently been associated with a recessively inherited multiple adenoma…”
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Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a Fok I variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding by Theodoratou, Evropi, Farrington, Susan M., Tenesa, Albert, McNeill, Geraldine, Cetnarskyj, Roseanne, Barnetson, Rebecca A., Porteous, Mary E., Dunlop, Malcolm G., Campbell, Harry

“…Abstract Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many…”
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Genome-wide association scan identifies a colorectal cancer susceptibility locus on llq23 and replicates risk loci at 8q24 and 18q21 by TENESA, Albert, FARRINGTON, Susan M, SEMPLE, Colin, CLARK, Andrew J, REID, Fiona J. L, SMITH, Lorna A, KAVOUSSANAKIS, Kostas, KOESSLER, Thibaud, PHAROAH, Paul D. P, BUCH, Stephan, SCHAFMAYER, Clemens, TEPEL, Jürgen, PRENDERGAST, James G. D, SCHREIBER, Stefan, VÖLZKE, Henry, SCHMIDT, Carsten O, HAMPE, Jochen, CHANG-CLAUDE, Jenny, HOFFMEISTER, Michael, BRENNER, Hermann, WILKENING, Stefan, CANZIAN, Federico, CAPELLA, Gabriel, PORTEOUS, Mary E, MORENO, Victor, DEARY, Ian J, STARR, John M, TOMLINSON, Ian P. M, KEMP, Zoe, HOWARTH, Kimberley, CARVAJAL-CARMONA, Luis, WEBB, Emily, BRODERICK, Peter, VIJAYAKRISHNAN, Jayaram, WALKER, Marion, HOULSTON, Richard S, RENNERT, Gad, BALLINGER, Dennis, ROZEK, Laura, GRUBER, Stephen B, MATSUDA, Koichi, KIDOKORO, Tomohide, NAKAMURA, Yusuke, ZANKE, Brent W, GREENWOOD, Celia M. T, HAQ, Naila, RANGREJ, Jagadish, KUSTRA, Rafal, MONTPETIT, Alexandre, HUDSON, Thomas J, GALLINGER, Steven, CAMPBELL, Harry, DUNLOP, Malcolm G, BARNETSON, Rebecca A, THEODORATOU, Evropi, CETNARSKYJ, Roseanne, CARTWRIGHT, Nicola

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