Search Results - "Barnes, Leo A"

Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis by Murphy, Eric A, Majeti, Bharat K, Barnes, Leo A, Makale, Milan, Weis, Sara M, Lutu-Fuga, Kimberly, Wrasidlo, Wolfgang, Cheresh, David A

“…Integrin ανβ3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an ανβ3-targeted…”
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Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK by Weis, Sara M, Lim, Ssang-Taek, Lutu-Fuga, Kimberly M, Barnes, Leo A, Chen, Xiao Lei, Göthert, Joachim R, Shen, Tang-Long, Guan, Jun-Lin, Schlaepfer, David D, Cheresh, David A

“…Focal adhesion kinase (FAK) plays a critical role during vascular development because knockout of FAK in endothelial cells (ECs) is embryonic lethal…”
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RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia by Shields, David J, Niessen, Sherry, Murphy, Eric A, Mielgo, Ainhoa, Desgrosellier, Jay S, Lau, Steven K.M, Barnes, Leo A, Lesperance, Jacqueline, Bouvet, Michael, Tarin, David, Cravatt, Benjamin F, Cheresh, David A

“…Pancreatic cancer is one of the most lethal malignancies. To discover functionally relevant modulators of pancreatic neoplasia, we performed activity-based…”
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Cooperation between VEGF and β3 integrin during cardiac vascular development by Weis, Sara M., Lindquist, Jeffrey N., Barnes, Leo A., Lutu-Fuga, Kimberly M., Cui, Jianhua, Wood, Malcolm R., Cheresh, David A.

“…In the developing myocardium, vascular endothelial growth factor (VEGF)–dependent neovascularization occurs by division of existing vessels, a process that…”
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An integrin α v β 3 -c-Src oncogenic unit promotes anchorage-independence and tumor progression by Tarin, David, Shattil, Sanford J, Lau, Steven K, Cheresh, David A, Prévost, Nicolas, Desgrosellier, Jay S, Huang, Miller, Barnes, Leo A, Shields, David J

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An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression by Desgrosellier, Jay S, Barnes, Leo A, Shields, David J, Huang, Miller, Lau, Steven K, Prévost, Nicolas, Tarin, David, Shattil, Sanford J, Cheresh, David A

“…Integrins regulate adhesion-dependent growth, survival and invasion of tumor cells. In particular, expression of integrin alpha(v)beta(3) is associated with…”
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Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G1–S Checkpoint by Zhu, Dan, Xu, Shuichan, Deyanat-Yazdi, Gordafaried, Peng, Sophie X., Barnes, Leo A., Narla, Rama Krishna, Tran, Tam, Mikolon, David, Ning, Yuhong, Shi, Tao, Jiang, Ning, Raymon, Heather K., Riggs, Jennifer R., Boylan, John F.

“…Abstract Historically, phenotypic-based drug discovery has yielded a high percentage of novel drugs while uncovering new tumor biology. CC-671 was discovered…”
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Synthetic Lethal Strategy Identifies a Potent and Selective TTK and CLK1/2 Inhibitor for Treatment of Triple-Negative Breast Cancer with a Compromised G 1 -S Checkpoint by Zhu, Dan, Xu, Shuichan, Deyanat-Yazdi, Gordafaried, Peng, Sophie X, Barnes, Leo A, Narla, Rama Krishna, Tran, Tam, Mikolon, David, Ning, Yuhong, Shi, Tao, Jiang, Ning, Raymon, Heather K, Riggs, Jennifer R, Boylan, John F

“…Historically, phenotypic-based drug discovery has yielded a high percentage of novel drugs while uncovering new tumor biology. CC-671 was discovered using a…”
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Targeted nanogels: a versatile platform for drug delivery to tumors by Murphy, Eric A, Majeti, Bharat K, Mukthavaram, Rajesh, Acevedo, Lisette M, Barnes, Leo A, Cheresh, David A

“…Although nanoparticle-based drug delivery formulations can improve the effectiveness and safety of certain anticancer drugs, many drugs, due to their chemical…”
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Specific Cross-talk between Epidermal Growth Factor Receptor and Integrin αvβ5 Promotes Carcinoma Cell Invasion and Metastasis by RICONO, Jill M, HUANG, Miller, BARNES, Leo A, LAU, Steven K, WEIRS, Sara M, SCHLAEPFER, David D, HANKS, Steven K, CHERESH, David A

“…Abstract Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. Previously, we showed that epidermal growth factor…”
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Abstract 3841: An integrin αvβ3/c-Src oncogenic unit promotes anchorage independence and tumor progression by Desgrosellier, Jay S., Seguin, Laetitia, Barnes, Leo A., Shields, David J., Huang, Miller, Lau, Steven K., Prevost, Nicolas, Tarin, David, Shattil, Sanford J., Cheresh, David A.

“…Abstract Integrins regulate adhesion-dependent growth, survival and invasion of tumor cells. In particular, expression of integrin αvβ3 is associated with…”
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An integrin [alpha]v[beta]3-c-Src oncogenic unit promotes anchorage-independence and tumor progression by Desgrosellier, Jay S, Barnes, Leo A, Shields, David J, Huang, Miller, Lau, Steven K, Prévost, Nicolas, Tarin, David, Shattil, Sanford J, Cheresh, David A

“…Integrins regulate adhesion-dependent growth, survival and invasion of tumor cells. In particular, expression of integrin alphavbeta3 is associated with…”
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An integrin [α.sub.v][β.sub.3]-c-Src oncogenic unit promotes anchorage-independence and tumor progression by Desgrosellier, Jay S, Barnes, Leo A, Shields, David J, Huang, Miller, Lau, Steven K, Prevost, Nicolas, Tarin, David, Shattil, Sanford J, Cheresh, David A

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An integrin alpha sub(v) beta sub(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression by Desgrosellier, Jay S, Barnes, Leo A, Shields, David J, Huang, Miller, Lau, Steven K, Prevost, Nicolas, Tarin, David, Shattil, Sanford J, Cheresh, David A

“…Integrins regulate adhesion-dependent growth, survival and invasion of tumor cells. In particular, expression of integrin alpha sub(v) beta sub(3) is…”
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An integrin αvβ3–c-Src oncogenic unit promotes anchorage-independence and tumor progression by Desgrosellier, Jay S, Barnes, Leo A, Shields, David J, Huang, Miller, Lau, Steven K, Prévost, Nicolas, Tarin, David, Shattil, Sanford J, Cheresh, David A

“…Integrins regulate adhesion-dependent growth, survival and invasion of tumor cells. In particular, expression of integrin α v β 3 is associated with…”
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Specific crosstalk between EGFR and integrin αvβ5 promotes carcinoma cell invasion and metastasis by Ricono, Jill M., Huang, Miller, Barnes, Leo A., Lau, Steven K., Weis, Sara M., Schlaepfer, David D., Hanks, Steven K., Cheresh, David A.

“…Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. Previously, we demonstrated that EGF stimulation of…”
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Cooperation between VEGF and beta3 integrin during cardiac vascular development by Weis, Sara M, Lindquist, Jeffrey N, Barnes, Leo A, Lutu-Fuga, Kimberly M, Cui, Jianhua, Wood, Malcolm R, Cheresh, David A

“…In the developing myocardium, vascular endothelial growth factor (VEGF)-dependent neovascularization occurs by division of existing vessels, a process that…”
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Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis by Ricono, Jill M, Huang, Miller, Barnes, Leo A, Lau, Steven K, Weis, Sara M, Schlaepfer, David D, Hanks, Steven K, Cheresh, David A

“…Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. Previously, we showed that epidermal growth factor (EGF)…”
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Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis by Eric A. Murphy, Bharat K. Majeti, Leo A. Barnes, Milan Makale, Sara M. Weis, Kimberly Lutu-Fuga, Wolfgang Wrasidlo, David A. Cheresh

“…Integrin ανβ3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an ανβ3-targeted…”
Get full text