Search Results - "Barnes, Christopher O."

Evolution of antibody immunity to SARS-CoV-2 by Gaebler, Christian, Wang, Zijun, Lorenzi, Julio C. C., Muecksch, Frauke, Finkin, Shlomo, Tokuyama, Minami, Cho, Alice, Jankovic, Mila, Schaefer-Babajew, Dennis, Oliveira, Thiago Y., Cipolla, Melissa, Viant, Charlotte, Barnes, Christopher O., Bram, Yaron, Breton, Gaëlle, Hägglöf, Thomas, Mendoza, Pilar, Hurley, Arlene, Turroja, Martina, Gordon, Kristie, Millard, Katrina G., Ramos, Victor, Schmidt, Fabian, Weisblum, Yiska, Jha, Divya, Tankelevich, Michael, Martinez-Delgado, Gustavo, Yee, Jim, Patel, Roshni, Dizon, Juan, Unson-O’Brien, Cecille, Shimeliovich, Irina, Robbiani, Davide F., Zhao, Zhen, Gazumyan, Anna, Schwartz, Robert E., Hatziioannou, Theodora, Bjorkman, Pamela J., Mehandru, Saurabh, Bieniasz, Paul D., Caskey, Marina, Nussenzweig, Michel C.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date…”
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mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants by Wang, Zijun, Schmidt, Fabian, Weisblum, Yiska, Muecksch, Frauke, Barnes, Christopher O., Finkin, Shlomo, Schaefer-Babajew, Dennis, Cipolla, Melissa, Gaebler, Christian, Lieberman, Jenna A., Oliveira, Thiago Y., Yang, Zhi, Abernathy, Morgan E., Huey-Tubman, Kathryn E., Hurley, Arlene, Turroja, Martina, West, Kamille A., Gordon, Kristie, Millard, Katrina G., Ramos, Victor, Da Silva, Justin, Xu, Jianliang, Colbert, Robert A., Patel, Roshni, Dizon, Juan, Unson-O’Brien, Cecille, Shimeliovich, Irina, Gazumyan, Anna, Caskey, Marina, Bjorkman, Pamela J., Casellas, Rafael, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C.

“…Here we report on the antibody and memory B cell responses of a cohort of 20 volunteers who received the Moderna (mRNA-1273) or Pfizer–BioNTech (BNT162b2)…”
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SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies by Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.

“…The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding…”
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Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection by Wang, Zijun, Muecksch, Frauke, Schaefer-Babajew, Dennis, Finkin, Shlomo, Viant, Charlotte, Gaebler, Christian, Hoffmann, Hans- Heinrich, Barnes, Christopher O., Cipolla, Melissa, Ramos, Victor, Oliveira, Thiago Y., Cho, Alice, Schmidt, Fabian, Da Silva, Justin, Bednarski, Eva, Aguado, Lauren, Yee, Jim, Daga, Mridushi, Turroja, Martina, Millard, Katrina G., Jankovic, Mila, Gazumyan, Anna, Zhao, Zhen, Rice, Charles M., Bieniasz, Paul D., Caskey, Marina, Hatziioannou, Theodora, Nussenzweig, Michel C.

“…More than one year after its inception, the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice by Cohen, Alexander A, Gnanapragasam, Priyanthi N P, Lee, Yu E, Hoffman, Pauline R, Ou, Susan, Kakutani, Leesa M, Keeffe, Jennifer R, Wu, Hung-Jen, Howarth, Mark, West, Anthony P, Barnes, Christopher O, Nussenzweig, Michel C, Bjorkman, Pamela J

“…Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-related emergent zoonotic coronaviruses is urgently needed. We made…”
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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies by Barnes, Christopher O., West, Anthony P., Huey-Tubman, Kathryn E., Hoffmann, Magnus A.G., Sharaf, Naima G., Hoffman, Pauline R., Koranda, Nicholas, Gristick, Harry B., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. Cetrulo, Finkin, Shlomo, Hägglöf, Thomas, Hurley, Arlene, Millard, Katrina G., Weisblum, Yiska, Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Caskey, Marina, Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal…”
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Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies by Greaney, Allison J., Starr, Tyler N., Barnes, Christopher O., Weisblum, Yiska, Schmidt, Fabian, Caskey, Marina, Gaebler, Christian, Cho, Alice, Agudelo, Marianna, Finkin, Shlomo, Wang, Zijun, Poston, Daniel, Muecksch, Frauke, Hatziioannou, Theodora, Bieniasz, Paul D., Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J., Bloom, Jesse D.

“…Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions…”
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Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations by Muecksch, Frauke, Weisblum, Yiska, Barnes, Christopher O., Schmidt, Fabian, Schaefer-Babajew, Dennis, Wang, Zijun, C. Lorenzi, Julio C., Flyak, Andrew I., DeLaitsch, Andrew T., Huey-Tubman, Kathryn E., Hou, Shurong, Schiffer, Celia A., Gaebler, Christian, Da Silva, Justin, Poston, Daniel, Finkin, Shlomo, Cho, Alice, Cipolla, Melissa, Oliveira, Thiago Y., Millard, Katrina G., Ramos, Victor, Gazumyan, Anna, Rutkowska, Magdalena, Caskey, Marina, Nussenzweig, Michel C., Bjorkman, Pamela J., Hatziioannou, Theodora, Bieniasz, Paul D.

“…Antibodies elicited by infection accumulate somatic mutations in germinal centers that can increase affinity for cognate antigens. We analyzed 6 independent…”
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Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion by Wang, Haoqing, Barnes, Christopher O., Yang, Zhi, Nussenzweig, Michel C., Bjorkman, Pamela J.

“…HIV-1 Env, a trimer of gp120-gp41 heterodimers, mediates membrane fusion after binding host receptor CD4. Receptor binding displaces V1V2 loops from Env's…”
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De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2 by Linsky, Thomas W, Vergara, Renan, Codina, Nuria, Nelson, Jorgen W, Walker, Matthew J, Su, Wen, Barnes, Christopher O, Hsiang, Tien-Ying, Esser-Nobis, Katharina, Yu, Kevin, Reneer, Z Beau, Hou, Yixuan J, Priya, Tanu, Mitsumoto, Masaya, Pong, Avery, Lau, Uland Y, Mason, Marsha L, Chen, Jerry, Chen, Alex, Berrocal, Tania, Peng, Hong, Clairmont, Nicole S, Castellanos, Javier, Lin, Yu-Ru, Josephson-Day, Anna, Baric, Ralph S, Fuller, Deborah H, Walkey, Carl D, Ross, Ted M, Swanson, Ryan, Bjorkman, Pamela J, Gale, Jr, Michael, Blancas-Mejia, Luis M, Yen, Hui-Ling, Silva, Daniel-Adriano

“…We developed a de novo protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracellular host proteins to infect the…”
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Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques by Escolano, Amelia, Gristick, Harry B., Abernathy, Morgan E., Merkenschlager, Julia, Gautam, Rajeev, Oliveira, Thiago Y., Pai, Joy, West, Anthony P., Barnes, Christopher O., Cohen, Alexander A., Wang, Haoqing, Golijanin, Jovana, Yost, Daniel, Keeffe, Jennifer R., Wang, Zijun, Zhao, Peng, Yao, Kai-Hui, Bauer, Jens, Nogueira, Lilian, Gao, Han, Voll, Alisa V., Montefiori, David C., Seaman, Michael S., Gazumyan, Anna, Silva, Murillo, McGuire, Andrew T., Stamatatos, Leonidas, Irvine, Darrell J., Wells, Lance, Martin, Malcolm A., Bjorkman, Pamela J., Nussenzweig, Michel C.

“…Broadly neutralizing monoclonal antibodies protect against infection with HIV-1 in animal models, suggesting that a vaccine that elicits these antibodies would…”
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Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody by Schommers, Philipp, Gruell, Henning, Abernathy, Morgan E., Tran, My-Kim, Dingens, Adam S., Gristick, Harry B., Barnes, Christopher O., Schoofs, Till, Schlotz, Maike, Vanshylla, Kanika, Kreer, Christoph, Weiland, Daniela, Holtick, Udo, Scheid, Christof, Valter, Markus M., van Gils, Marit J., Sanders, Rogier W., Vehreschild, Jörg J., Cornely, Oliver A., Lehmann, Clara, Fätkenheuer, Gerd, Seaman, Michael S., Bloom, Jesse D., Bjorkman, Pamela J., Klein, Florian

“…Broadly neutralizing antibodies (bNAbs) represent a promising approach to prevent and treat HIV-1 infection. However, viral escape through mutation of the…”
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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV by Scheid, Johannes F., Barnes, Christopher O., Eraslan, Basak, Hudak, Andrew, Keeffe, Jennifer R., Cosimi, Lisa A., Brown, Eric M., Muecksch, Frauke, Weisblum, Yiska, Zhang, Shuting, Delorey, Toni, Woolley, Ann E., Ghantous, Fadi, Park, Sung-Moo, Phillips, Devan, Tusi, Betsabeh, Huey-Tubman, Kathryn E., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Rzasa, Kara, Hatziioanno, Theodora, Durney, Michael A., Gu, Xiebin, Tada, Takuya, Landau, Nathaniel R., West, Anthony P., Rozenblatt-Rosen, Orit, Seaman, Michael S., Baden, Lindsey R., Graham, Daniel B., Deguine, Jacques, Bieniasz, Paul D., Regev, Aviv, Hung, Deborah, Bjorkman, Pamela J., Xavier, Ramnik J.

“…Monoclonal antibodies (mAbs) are a focus in vaccine and therapeutic design to counteract severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its…”
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The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction by Wu, Ying, Zhou, Xiaohong, Barnes, Christopher O, DeLucia, Maria, Cohen, Aina E, Gronenborn, Angela M, Ahn, Jinwoo, Calero, Guillermo

“…The crystal structure of HIV-1 accessory protein Vpr in complex with human UNG2 and DDB1–DCAF1 provides insight into how the viral protein directs UNG2 for…”
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Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble by Barnes, Christopher O., Calero, Monica, Malik, Indranil, Graham, Brian W., Spahr, Henrik, Lin, Guowu, Cohen, Aina E., Brown, Ian S., Zhang, Qiangmin, Pullara, Filippo, Trakselis, Michael A., Kaplan, Craig D., Calero, Guillermo

“…Notwithstanding numerous published structures of RNA Polymerase II (Pol II), structural details of Pol II engaging a complete nucleic acid scaffold have been…”
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Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York by West, Anthony P., Wertheim, Joel O., Wang, Jade C., Vasylyeva, Tetyana I., Havens, Jennifer L., Chowdhury, Moinuddin A., Gonzalez, Edimarlyn, Fang, Courtney E., Di Lonardo, Steve S., Hughes, Scott, Rakeman, Jennifer L., Lee, Henry H., Barnes, Christopher O., Gnanapragasam, Priyanthi N. P., Yang, Zhi, Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Keeffe, Jennifer R., Bjorkman, Pamela J.

“…Wide-scale SARS-CoV-2 genome sequencing is critical to tracking viral evolution during the ongoing pandemic. We develop the software tool, Variant Database…”
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Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope by Schoofs, Till, Barnes, Christopher O., Suh-Toma, Nina, Golijanin, Jovana, Schommers, Philipp, Gruell, Henning, West, Anthony P., Bach, Franziska, Lee, Yu Erica, Nogueira, Lilian, Georgiev, Ivelin S., Bailer, Robert T., Czartoski, Julie, Mascola, John R., Seaman, Michael S., McElrath, M. Juliana, Doria-Rose, Nicole A., Klein, Florian, Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Broadly neutralizing antibodies (bNAbs) against HIV-1 envelope (Env) inform vaccine design and are potential therapeutic agents. We identified SF12 and related…”
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Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies by Jette, Claudia A., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Muecksch, Frauke, Lee, Yu E., Huey-Tubman, Kathryn E., Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., West, Anthony P., Keeffe, Jennifer R., Bjorkman, Pamela J., Barnes, Christopher O.

“…Many anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) neutralizing antibodies target the angiotensin-converting enzyme 2 (ACE2) binding…”
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Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope by Barnes, Christopher O., Gristick, Harry B., Freund, Natalia T., Escolano, Amelia, Lyubimov, Artem Y., Hartweger, Harald, West, Anthony P., Cohen, Aina E., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Broadly neutralizing antibodies (bNAbs) isolated from HIV-1-infected individuals inform HIV-1 vaccine design efforts. Developing bNAbs with increased efficacy…”
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Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation by Jette, Claudia A., Barnes, Christopher O., Kirk, Sharon M., Melillo, Bruno, Smith, Amos B., Bjorkman, Pamela J.

“…Human immunodeficiency virus-1 (HIV-1), the causative agent of AIDS, impacts millions of people. Entry into target cells is mediated by the HIV-1 envelope…”
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