Search Results - "Barnes, Betsy J."

Targeting potential drivers of COVID-19: Neutrophil extracellular traps by Barnes, Betsy J, Adrover, Jose M, Baxter-Stoltzfus, Amelia, Borczuk, Alain, Cools-Lartigue, Jonathan, Crawford, James M, Daßler-Plenker, Juliane, Guerci, Philippe, Huynh, Caroline, Knight, Jason S, Loda, Massimo, Looney, Mark R, McAllister, Florencia, Rayes, Roni, Renaud, Stephane, Rousseau, Simon, Salvatore, Steven, Schwartz, Robert E, Spicer, Jonathan D, Yost, Christian C, Weber, Andrew, Zuo, Yu, Egeblad, Mikala

“…Coronavirus disease 2019 (COVID-19) is a novel, viral-induced respiratory disease that in ∼10-15% of patients progresses to acute respiratory distress syndrome…”
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Modulating Cytokine Production via Select Packaging and Secretion From Extracellular Vesicles by Barnes, Betsy J, Somerville, Carter C

“…Cytokines are soluble factors that play vital roles in systemic function due to their ability to initiate and mediate cell-to-cell communication. Another…”
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Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: a case series by Weber, Andrew G, Chau, Alice S, Egeblad, Mikala, Barnes, Betsy J, Janowitz, Tobias

“…Mechanically ventilated patients with COVID-19 have a mortality of 24-53%, in part due to distal mucopurulent secretions interfering with ventilation. DNA from…”
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HMGB1–C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis by Liu, Tianye, Xiang, Alec, Peng, Travis, Doran, Amanda C., Tracey, Kevin J., Barnes, Betsy J., Tabas, Ira, Son, Myoungsun, Diamond, Betty

“…Macrophage polarization is critical to inflammation and resolution of inflammation. We previously showed that high-mobility group box 1 (HMGB1) can engage…”
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Detection of neutrophil extracellular traps in patient plasma: method development and validation in systemic lupus erythematosus and healthy donors that carry IRF5 genetic risk by Matta, Bharati, Battaglia, Jenna, Barnes, Betsy J

“…Neutrophil extracellular traps (NETs) are web-like structures extruded by neutrophils after activation or in response to microorganisms. These extracellular…”
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Inhibition of IRF5 hyperactivation protects from lupus onset and severity by Song, Su, De, Saurav, Nelson, Victoria, Chopra, Samin, LaPan, Margaret, Kampta, Kyle, Sun, Shan, He, Mingzhu, Thompson, Cherrie D, Li, Dan, Shih, Tiffany, Tan, Natalie, Al-Abed, Yousef, Capitle, Eugenio, Aranow, Cynthia, Mackay, Meggan, Clapp, William L, Barnes, Betsy J

“…The transcription factor IFN regulatory factor 5 (IRF5) is a central mediator of innate and adaptive immunity. Genetic variations within IRF5 are associated…”
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Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes by Akilesh, Holly M, Buechler, Matthew B, Duggan, Jeffrey M, Hahn, William O, Matta, Bharati, Sun, Xizhang, Gessay, Griffin, Whalen, Elizabeth, Mason, Michael, Presnell, Scott R, Elkon, Keith B, Lacy-Hulbert, Adam, Barnes, Betsy J, Pepper, Marion, Hamerman, Jessica A

“…Cytopenias are an important clinical problem associated with inflammatory disease and infection. We show that specialized phagocytes that internalize red blood…”
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T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation by Yan, Jie, Pandey, Surya P., Barnes, Betsy J., Turner, Jerrold R., Abraham, Clara

“…IRF5 polymorphisms are associated with multiple immune-mediated diseases, including ulcerative colitis. IRF5 contributions are attributed to its role in…”
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Therapeutic Targeting of IRFs: Pathway-Dependence or Structure-Based? by Thompson, Cherrie D, Matta, Bharati, Barnes, Betsy J

“…The interferon regulatory factors (IRFs) are a family of master transcription factors that regulate pathogen-induced innate and acquired immune responses…”
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TRIpartite motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms by Lazzari, Elisa, Korczeniewska, Justyna, Ní Gabhann, Joan, Smith, Siobhán, Barnes, Betsy J, Jefferies, Caroline A

“…IRF5 is a member of the Interferon Regulatory Factor (IRF) family of transcription factors activated downstream of the Toll-Like receptors (TLRs)…”
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IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation by Roberts, Bailey K., Li, Dan Iris, Somerville, Carter, Matta, Bharati, Jha, Vaishali, Steinke, Adison, Brune, Zarina, Blanc, Lionel, Soffer, Samuel Z., Barnes, Betsy J.

“…Metastasis is driven by extensive cooperation between a tumor and its microenvironment, resulting in the adaptation of molecular mechanisms that evade the…”
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B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation by De, Saurav, Zhang, Baohong, Shih, Tiffany, Singh, Sukhwinder, Winkler, Aaron, Donnelly, Robert, Barnes, Betsy J

“…Upon recognition of antigen, B cells undergo rapid proliferation followed by differentiation to specialized antibody secreting cells (ASCs). During this…”
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Potential T Cell-Intrinsic Regulatory Roles for IRF5 via Cytokine Modulation in T Helper Subset Differentiation and Function by Brune, Zarina, Rice, Matthew R, Barnes, Betsy J

“…Interferon Regulatory Factor 5 (IRF5) is one of nine members of the IRF family of transcription factors. Although initially discovered as a key regulator of…”
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IRF-5 Is a Mediator of the Death Receptor-induced Apoptotic Signaling Pathway by Hu, Guodong, Barnes, Betsy J.

“…The efficient and regulated response to cellular stress is coordinated by a genetic regulatory network in which a given transcription factor controls the…”
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Insulin-like growth factor receptor signaling in breast tumor epithelium protects cells from endoplasmic reticulum stress and regulates the tumor microenvironment by Obr, Alison E, Kumar, Sushil, Chang, Yun-Juan, Bulatowicz, Joseph J, Barnes, Betsy J, Birge, Raymond B, Lazzarino, Deborah A, Gallagher, Emily, LeRoith, Derek, Wood, Teresa L

“…Early analyses of human breast cancer identified high expression of the insulin-like growth factor type 1 receptor (IGF-1R) correlated with hormone receptor…”
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RNAi Transfection Optimized in Primary Naïve B Cells for the Targeted Analysis of Human Plasma Cell Differentiation by Shih, Tiffany, De, Saurav, Barnes, Betsy J

“…Upon antigen recognition, naïve B cells undergo rapid proliferation followed by differentiation to specialized antibody secreting cells (ASCs), called plasma…”
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The COP9 Signalosome Interacts with and Regulates Interferon Regulatory Factor 5 Protein Stability by Korczeniewska, Justyna, Barnes, Betsy J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Irf5‐deficient mice are protected from pristane‐induced lupus via increased Th2 cytokines and altered IgG class switching by Feng, Di, Yang, Lisong, Bi, Xiaohui, Stone, Rivka C., Patel, Priya, Barnes, Betsy J.

“…Polymorphisms in the transcription factor interferon (IFN) regulatory factor 5 (IRF5) have been identified that show a strong association with an increased…”
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RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE by Stone, Rivka C, Du, Peicheng, Feng, Di, Dhawan, Kopal, Rönnblom, Lars, Eloranta, Maija-Leena, Donnelly, Robert, Barnes, Betsy J

“…Polymorphisms in the interferon regulatory factor 5 (IRF5) gene have been consistently replicated and shown to confer risk for or protection from the…”
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Interferon regulatory factor 5 activation in monocytes of systemic lupus erythematosus patients is triggered by circulating autoantigens independent of type I interferons by Stone, Rivka C., Feng, Di, Deng, Jing, Singh, Sukhwinder, Yang, Lisong, Fitzgerald-Bocarsly, Patricia, Eloranta, Maija-Leena, Rönnblom, Lars, Barnes, Betsy J.

“…Objective Genetic variants of interferon regulatory factor 5 (IRF‐5) are associated with susceptibility to systemic lupus erythematosus (SLE). IRF‐5 regulates…”
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