Search Results - "Barnardo, Martin"

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21 by van Heel, David A, Franke, Lude, Hunt, Karen A, Gwilliam, Rhian, Zhernakova, Alexandra, Inouye, Mike, Wapenaar, Martin C, Barnardo, Martin C N M, Bethel, Graeme, Holmes, Geoffrey K T, Feighery, Con, Jewell, Derek, Kelleher, Dermot, Kumar, Parveen, Travis, Simon, Walters, Julian RF, Sanders, David S, Howdle, Peter, Swift, Jill, Playford, Raymond J, McLaren, William M, Mearin, M Luisa, Mulder, Chris J, McManus, Ross, McGinnis, Ralph, Cardon, Lon R, Deloukas, Panos, Wijmenga, Cisca

“…We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding…”
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Distinct HLA associations of LGI1 and CASPR2-antibody diseases by Binks, Sophie, Varley, James, Lee, Wanseon, Makuch, Mateusz, Elliott, Katherine, Gelfand, Jeffrey M, Jacob, Saiju, Leite, M Isabel, Maddison, Paul, Chen, Mian, Geschwind, Michael D, Grant, Eleanor, Sen, Arjune, Waters, Patrick, McCormack, Mark, Cavalleri, Gianpiero L, Barnardo, Martin, Knight, Julian C, Irani, Sarosh R

“…The mechanisms responsible for the generation of LGI1- or CASPR2-antibodies are unknown. Binks et al. describe two strikingly dichotomous HLA-associations,…”
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HLA class I alleles tag HLA-DRB11501 haplotypes for differential risk in multiple sclerosis susceptibility by Chao, Michael J, Barnardo, Martin C.N.M, Lincoln, Matthew R, Ramagopalan, Sreeram V, Herrera, Blanca M, Dyment, David A, Montpetit, Alexandre, Sadovnick, A. Dessa, Knight, Julian C, Ebers, George C

“…The major locus for multiple sclerosis (MS) susceptibility is located within the class II region of the Major Histocompatibility Complex (MHC). HLA-DRB1…”
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CD4 T-helper responses to the anaplastic lymphoma kinase (ALK) protein in patients with ALK-positive anaplastic large-cell lymphoma by AIT-TAHAR, Kamel, BARNARDO, Martin C. N, PULFORD, Karen

“…We have previously shown both humoral and CTL responses to anaplastic lymphoma kinase (ALK) in patients with ALK-positive anaplastic large-cell lymphoma…”
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Role of Anti-Vimentin Antibodies in Renal Transplantation by Besarani, Dler, Cerundolo, Lucia, Smith, John D, Procter, Jeanette, Barnardo, Martin C N, Roberts, Ian S D, Friend, Peter J, Rose, Marlene L, Fuggle, Susan V

“…BACKGROUNDThe role of non-HLA antibodies in rejection is not clear. We investigate whether antibodies to vimentin are made after renal transplantation and if…”
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High resolution HLA haplotyping by imputation for a British population bioresource by Neville, Matt J, Lee, Wanseon, Humburg, Peter, Wong, Daniel, Barnardo, Martin, Karpe, Fredrik, Knight, Julian C

“…Abstract This study aimed to establish the occurrence and frequency of HLA alleles and haplotypes for a healthy British Caucasian population bioresource from…”
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CD4 and CD8 T cell responses to tumour-associated Epstein–Barr virus antigens in nasopharyngeal carcinoma patients by Lin, Xiaorong, Gudgeon, Nancy H., Hui, Edwin P., Jia, Hui, Qun, Xue, Taylor, Graham S., Barnardo, Martin C. N. M., Lin, C. Kit, Rickinson, Alan B., Chan, Anthony T. C.

“…Nasopharyngeal carcinoma (NPC), an Epstein–Barr virus (EBV)-associated tumour common in Southern Chinese populations, is a potentially important target for T…”
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The pharmacogenetics of methotrexate in inflammatory bowel disease by Herrlinger, Klaus R, Cummings, J.R Fraser, Barnardo, Martin C.N.M, Schwab, Matthias, Ahmad, Tariq, Jewell, Derek P

“…OBJECTIVESMethotrexate (MTX) is an effective immunosuppressive treatment in inflammatory bowel disease (IBD) but its use is limited by unpredictable toxicity…”
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The Association Between HLA DR, DQ Antigens, and Vulval Lichen Sclerosus in the UK: HLA DRB112 and its Associated DRB112/DQB10301/04/09/010 Haplotype Confers Susceptibility to Vulval Lichen Sclerosus, and HLA DRB10301/04 and its Associated DRB10301/04/DQB10201/02/03 Haplotype Protects from Vulval Lichen Sclerosus by Gao, Xing-Hua, Barnardo, Martin C.M.N., Winsey, Samantha, Ahmad, Tariq, Cook, Julia, Agudelo, Juliet D., Zhai, Ning, Powell, Jenny J., Fuggle, Susan V., Wojnarowska, Fenella

“…Lichen sclerosus (LS) is considered to have an immunogenetic background. Several small studies, using serological typing, have reported that HLA-DR11, DR12,…”
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Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium by Chao, Michael J., Barnardo, Martin C.N.M., Lui, Guang-zhi, Lincoln, Matthew R., Ramagopalan, Sreeram V., Herrera, Blanca M., Dyment, David A., Sadovnick, A. Dessa, Ebers, George C.

“…The human major histocompatibility complex (MHC) class II region is associated with genetic susceptibility to multiple sclerosis (MS). Roles for HLA class I…”
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Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity? by Lehmann, Donald J, Barnardo, Martin C N M, Fuggle, Susan, Quiroga, Isabel, Sutherland, Andrew, Warden, Donald R, Barnetson, Lin, Horton, Roger, Beck, Stephan, Smith, A David

“…There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively…”
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C4d deposition in early renal allograft protocol biopsies by KOO, Dicken D. H, ROBERTS, Ian S. D, FUGGLE, Susan V, QUIROGA, Isabel, PROCTER, Jeanette, BARNARDO, Martin C. N. M, SUTTON, Margaret, CERUNDOLO, Lucia, DAVIES, David R, FRIEND, Peter J, MORRIS, Peter J

“…Deposition of the complement protein C4d in renal allograft biopsies obtained during graft dysfunction and rejection has been proposed to be a sensitive marker…”
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Sp17 Protein Expression and Major Histocompatibility Class I and II Epitope Presentation in Diffuse Large B Cell Lymphoma Patients by Pulford, Karen, Hatton, Chris S. R., Collins, Graham P., Barnardo, Martin, Anderson, Amanda P., Ait-Tahar, Kamel, Banham, Alison H.

“…Improved therapies are urgently needed for patients with diffuse large B cell lymphoma (DLBCL). Success using immune checkpoint inhibitors and chimeric antigen…”
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Quantifiable Cytotoxic T Lymphocyte Responses and HLA-Related Risk of Progression to AIDS by Scherer, Almut, Frater, John, Oxenius, Annette, Agudelo, Juliet, Price, David A., Günthard, Huldrych F., Barnardo, Martin, Perrin, Luc, Hirschel, Bernard, Phillips, Rodney E., McLean, Angela R., The Swiss HIV Cohort Study, May, Robert

“…There are significant associations between possession of certain HLA class I alleles and rate of progression to AIDS. Immunological data provide an explanatory…”
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CD4-positive T-helper cell responses to the PASD1 protein in patients with diffuse large B-cell lymphoma by Ait-Tahar, Kamel, Liggins, Amanda P, Collins, Graham P, Campbell, Andrew, Barnardo, Martin, Cabes, Maite, Lawrie, Charles H, Moir, Donald, Hatton, Chris, Banham, Alison H, Pulford, Karen

“…Vaccine development targeting the novel immunogenic Per ARNT Sim Domain containing 1 (PASD1) cancer testis antigen represents an attractive therapeutic…”
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Is there MHC class II restriction of the response to MHC class I in transplant patients? by PAPASSAVAS, Andreas C, BARNARDO, Martin C. N. M, BUNCE, Mike, WELSH, Kenneth I

“…In this study, we evaluated distinct HLA-DRB1 alleles to determine class II restriction of the production of HLA-A2-specific antibodies in renal transplant…”
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Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients by Carr, Edward J, Wu, Mary, Harvey, Ruth, Wall, Emma C, Kelly, Gavin, Hussain, Saira, Howell, Michael, Kassiotis, George, Swanton, Charles, Gandhi, Sonia, Bauer, David LV, Adenwalla, Sherna F, Bird, Paul, Holmes, Christopher, Hull, Katherine L, March, Daniel S, Selvaskandan, Haresh, Silva, Jorge J, Tang, Julian W, Hester, Joanna, Issa, Fadi, Barnardo, Martin, Friend, Peter J, Davenport, Andrew, Goodlad, Catriona, Gopalan, Vignesh, Tangwonglert, Theerasak, Stauss, Hans J, Richter, Alex G, Cunningham, Adam F, Perez-Toledo, Marisol, Banham, Gemma D, Wall, Nadya, Clarke, Candice L, Prendecki, Maria, Clayton, Bobbi, Namjou, Sina, Silva, Vanessa, Poulten, Meghan, Bawumia, Philip, Miah, Murad, Sade, Samuel, Miranda, Mauro, Taylor, Tom, D'Angelo, Ilenia, Cabrera Jarana, Mercedes, Rahman, Mahbubur, Abreu, Janet, Sandhar, Sandeep, Bailey, Neil, Caidan, Simon, Caulfield, Marie, Wu, Mary, Harvey, Ruth, Adams, Lorin, Kavanagh, Caitlin, Warchal, Scott, Sawyer, Chelsea, Gavrielides, Mike, Kandasamy, Jag, Ambrose, Karen, Strange, Amy, Abiola, Titilayo, O'Reilly, Nicola, Hobson, Philip, Agau-Doce, Ana, Russell, Emma, Riddell, Andrew, Kjaer, Svend, Borg, Annabel, Roustan, Chloë, Billany, Roseanne E, Graham-Brown, Matthew PM, Beckett, Joseph, Bull, Katherine, Shankar, Sushma, Henderson, Scott, Motallebzadeh, Reza, Salama, Alan D, Harper, Lorraine, Mark, Patrick B, McAdoo, Stephen, Willicombe, Michelle, Beale, Rupert

“…[...]the subunit hepatitis B vaccine had to be re-formulated for this patient group to deliver a higher antigenic dose.3 There is uncertainty whether an mRNA…”
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Guidance for laboratories performing molecular pathology for cancer patients by Cree, Ian A, Deans, Zandra, Ligtenberg, Marjolijn J L, Normanno, Nicola, Edsjö, Anders, Rouleau, Etienne, Solé, Francesc, Thunnissen, Erik, Timens, Wim, Schuuring, Ed, Dequeker, Elisabeth, Murray, Samuel, Dietel, Manfred, Groenen, Patricia, Van Krieken, J Han

“…Molecular testing is becoming an important part of the diagnosis of any patient with cancer. The challenge to laboratories is to meet this need, using reliable…”
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Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation by Goulder, Philip J.R, Pasquier, Christophe, Holmes, Eddie C, Liang, Bin, Tang, Yanhua, Izopet, Jacques, Saune, Karine, Rosenberg, Eric S, Burchett, Sandra K, McIntosh, Kenneth, Barnardo, Martin, Bunce, Michael, Walker, Bruce D, Brander, Christian, Phillips, Rodney E

“…Cytotoxic T lymphocytes (CTL) play a central role in containment of HIV infection. Evasion of the immune response by CTL escape is associated with progression…”
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HLA-DQA1–HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants by Heap, Graham A, Weedon, Michael N, Bewshea, Claire M, Singh, Abhey, Chen, Mian, Satchwell, Jack B, Vivian, Julian P, So, Kenji, Dubois, Patrick C, Andrews, Jane M, Annese, Vito, Bampton, Peter, Barnardo, Martin, Bell, Sally, Cole, Andy, Connor, Susan J, Creed, Tom, Cummings, Fraser R, D'Amato, Mauro, Daneshmend, Tawfique K, Fedorak, Richard N, Florin, Timothy H, Gaya, Daniel R, Greig, Emma, Halfvarson, Jonas, Hart, Alisa, Irving, Peter M, Jones, Gareth, Karban, Amir, Lawrance, Ian C, Lee, James C, Lees, Charlie, Lev-Tzion, Raffi, Lindsay, James O, Mansfield, John, Mawdsley, Joel, Mazhar, Zia, Parkes, Miles, Parnell, Kirstie, Orchard, Timothy R, Radford-Smith, Graham, Russell, Richard K, Reffitt, David, Satsangi, Jack, Silverberg, Mark S, Sturniolo, Giacomo C, Tremelling, Mark, Tsianos, Epameinondas V, van Heel, David A, Walsh, Alissa, Watermeyer, Gill, Weersma, Rinse K, Zeissig, Sebastian, Rossjohn, Jamie, Holden, Arthur L, Ahmad, Tariq

“…Graham Heap, Tariq Ahmad and colleagues show that common variants in the HLA-DQA1–HLA-DRB1 region confer susceptibility to thiopurine-induced pancreatitis in…”
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