Search Results - "Barnard, Linley"

Early metabolic profiling of pyrido[1,2-a]benzimidazoles in mouse liver microsomes by LC-MS/MS by Brunschwig, Christel, Singh, Kawaljit, Barnard, Linley, Ndubi, Ferdinand, Okombo, John, Njoroge, Mathew, Wiesner, Lubbe, Chibale, Kelly

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Cyclopalladated organosilane-tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity by Adams, Muneebah, Barnard, Linley, de Kock, Carmen, Smith, Peter J, Wiesner, Lubbe, Chibale, Kelly, Smith, Gregory S

“…Two series of ferrocenyl- and aryl-derived cyclopalladated organosilane thiosemicarbazone complexes were synthesised via C-H bond activation. Selected…”
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Antimalarial Pyrido[1,2‑a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies by Okombo, John, Brunschwig, Christel, Singh, Kawaljit, Dziwornu, Godwin Akpeko, Barnard, Linley, Njoroge, Mathew, Wittlin, Sergio, Chibale, Kelly

“…A novel series of pyrido­[1,2-a]­benzimidazoles bearing Mannich base side chains and their metabolites were synthesized and evaluated for in…”
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Antimalarial Pyrido[1,2‑a]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model by Singh, Kawaljit, Okombo, John, Brunschwig, Christel, Ndubi, Ferdinand, Barnard, Linley, Wilkinson, Chad, Njogu, Peter M, Njoroge, Mathew, Laing, Lizahn, Machado, Marta, Prudêncio, Miguel, Reader, Janette, Botha, Mariette, Nondaba, Sindisiwe, Birkholtz, Lyn-Marie, Lauterbach, Sonja, Churchyard, Alisje, Coetzer, Theresa L, Burrows, Jeremy N, Yeates, Clive, Denti, Paolo, Wiesner, Lubbe, Egan, Timothy J, Wittlin, Sergio, Chibale, Kelly

“…Further structure–activity relationship (SAR) studies on the recently identified pyrido­[1,2-a]­benzimidazole (PBI) antimalarials have led to the…”
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Antischistosomal Activity of Pyrido[1,2‑a]benzimidazole Derivatives and Correlation with Inhibition of β‑Hematin Formation by Okombo, John, Singh, Kawaljit, Mayoka, Godfrey, Ndubi, Ferdinand, Barnard, Linley, Njogu, Peter M, Njoroge, Mathew, Gibhard, Liezl, Brunschwig, Christel, Vargas, Mireille, Keiser, Jennifer, Egan, Timothy J, Chibale, Kelly

“…The extensive use of praziquantel against schistosomiasis raises concerns about drug resistance. New therapeutic alternatives targeting critical pathways…”
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