Search Results - "Barn, David"

The discovery of novel indole-2-carboxamides as cannabinoid CB1 receptor antagonists by Cowley, Phillip M., Baker, James, Barn, David R., Buchanan, Kirsteen I., Carlyle, Ian, Clark, John K., Clarkson, Thomas R., Deehan, Maureen, Edwards, Darren, Goodwin, Richard R., Jaap, David, Kiyoi, Yasuko, Mort, Chris, Palin, Ronald, Prosser, Alan, Walker, Glenn, Ward, Nick, Wishart, Grant, Young, Trevor

“…The discovery and structure–activity relationship of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB1 receptor is disclosed. Compound…”
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Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists by Palin, Ronald, Barn, David R., Clark, John K., Cottney, Jean E., Cowley, Phillip M., Crockatt, Marc, Evans, Louise, Feilden, Helen, Goodwin, Richard R., Griekspoor, Frank, Grove, Simon J.A., Houghton, Andrea K., Jones, Philip S., Morphy, Richard J., Smith, Alasdair R.C., Sundaram, Hardy, Vrolijk, David, Weston, Mark A., Wishart, Grant, Wren, Paul

“…A series of potent and soluble ORL1 agonists was prepared and evaluated. Compound 41 showed antinociceptive properties in mouse formalin paw test (ED 50 = 1.07…”
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Optimisation of pharmacokinetic properties to afford an orally bioavailable and selective V 1A receptor antagonist by Arbuckle, William, Baker, James, Barn, David, Bingham, Matilda, Brown, Angus, Buchanan, Kirsteen, Craighead, Mark, Goodwin, Richard, Goutcher, Susan, Kiczun, Michael, Lyons, Amanda, Milne, Rachel, Montgomery, Brian, Napier, Susan, Presland, Jeremy, Sloan, Hazel, Turnbull, Zara, Wishart, Grant

“…The previously described lead compound 5 is a potent and selective V 1A antagonist with affinity at both the rat and human receptor, but displays poor oral…”
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The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V 1A receptor antagonists by Napier, Susan, Wishart, Grant, Arbuckle, William, Baker, James, Barn, David, Bingham, Matilda, Brown, Angus, Byford, Alan, Claxton, Chris, Craighead, Mark, Buchanan, Kirsteen, Fielding, Lee, Gibson, Lindsay, Goodwin, Richard, Goutcher, Susan, Irving, Nicholas, MacSweeney, Cliona, Milne, Rachel, Mort, Chris, Presland, Jeremy, Sloan, Hazel, Thomson, Fiona, Turnbull, Zara, Young, Trevor

“…The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V 1A receptor is disclosed…”
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Optimisation of pharmacokinetic properties to afford an orally bioavailable and selective V₁A receptor antagonist by Arbuckle, William, Baker, James, Barn, David, Bingham, Matilda, Brown, Angus, Buchanan, Kirsteen, Craighead, Mark, Goodwin, Richard, Goutcher, Susan, Kiczun, Michael, Lyons, Amanda, Milne, Rachel, Montgomery, Brian, Napier, Susan, Presland, Jeremy, Sloan, Hazel, Turnbull, Zara, Wishart, Grant

“…The previously described lead compound 5 is a potent and selective V₁A antagonist with affinity at both the rat and human receptor, but displays poor oral…”
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Optimisation of pharmacokinetic properties to afford an orally bioavailable and selective V sub(1A receptor antagonist) by Arbuckle, William, Baker, James, Barn, David, Bingham, Matilda, Brown, Angus, Buchanan, Kirsteen, Craighead, Mark, Goodwin, Richard, Goutcher, Susan, Kiczun, Michael, Lyons, Amanda, Milne, Rachel, Montgomery, Brian, Napier, Susan, Presland, Jeremy, Sloan, Hazel, Turnbull, Zara, Wishart, Grant

“…The previously described lead compound 5 is a potent and selective V sub(1A antagonist with affinity at both the rat and human receptor, but displays poor oral…”
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discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V₁A receptor antagonists by Napier, Susan, Wishart, Grant, Arbuckle, William, Baker, James, Barn, David, Bingham, Matilda, Brown, Angus, Byford, Alan, Claxton, Chris, Craighead, Mark, Buchanan, Kirsteen, Fielding, Lee, Gibson, Lindsay, Goodwin, Richard, Goutcher, Susan, Irving, Nicholas, MacSweeney, Cliona, Milne, Rachel, Mort, Chris, Presland, Jeremy, Sloan, Hazel, Thomson, Fiona, Turnbull, Zara, Young, Trevor

“…The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V₁A receptor is disclosed…”
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The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V sub(1A receptor antagonists by Napier, Susan, Wishart, Grant, Arbuckle, William, Baker, James, Barn, David, Bingham, Matilda, Brown, Angus, Byford, Alan, Claxton, Chris, Craighead, Mark, Buchanan, Kirsteen, Fielding, Lee, Gibson, Lindsay, Goodwin, Richard, Goutcher, Susan, Irving, Nicholas, MacSweeney, Cliona, Milne, Rachel, Mort, Chris, Presland, Jeremy, Sloan, Hazel, Thomson, Fiona, Turnbull, Zara, Young, Trevor

“…The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V sub(1A receptor is disclosed…”
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Solid-Phase Synthesis of Cyclic Imides by Barn, David R, Morphy, J. Richard

“…A cyclative cleavage strategy for the synthesis of cyclic imides on a polystyrene resin is described. After optimization of the cleavage conditions, a small…”
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Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters by Barn, David R., Richard Morphy, J., Rees, David C.

“…A new method for the synthesis of amino amides using Wang or Tentagel-PHB resins is described. The method uses aluminium chloride to promote the conversion of…”
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The discovery of novel indole-2-carboxamides as cannabinoid CB(1) receptor antagonists by Cowley, Phillip M, Baker, James, Barn, David R, Buchanan, Kirsteen I, Carlyle, Ian, Clark, John K, Clarkson, Thomas R, Deehan, Maureen, Edwards, Darren, Goodwin, Richard R, Jaap, David, Kiyoi, Yasuko, Mort, Chris, Palin, Ronald, Prosser, Alan, Walker, Glenn, Ward, Nick, Wishart, Grant, Young, Trevor

“…The discovery and structure-activity relationship of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB(1) receptor is disclosed…”
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Stroke following marijuana smoking by Barnes, D, Palace, J, O'Brien, M D

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