Search Results - "Barlow, Norman J"

Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to di(n-butyl) phthalate by BARLOW, Norman J, FOSTER, Paul M. D

“…Di(n-butyl) phthalate (DBP) acts as an antiandrogen by decreasing fetal testicular testosterone synthesis when male rats are exposed in utero. DBP-exposed male…”
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Male Reproductive Tract Lesions at 6, 12, and 18 Months of Age Following in Utero Exposure to Di(n-butyl) Phthalate by Barlow, Norman J., Mcintyre, Barry S., Foster, Paul M.D.

“…In utero exposure of male rats to the antiandrogen di(n-butyl) phthalate (DBP) leads to decreased anogenital distance (AGD) on postnatal day (PND) 1, increased…”
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Effects of in Utero Exposure to Linuron on Androgen-Dependent Reproductive Development in the Male Crl:CD(SD)BR Rat by McIntyre, Barry S., Barlow, Norman J., Wallace, Duncan G., Maness, Susan C., Gaido, Kevin W., Foster, Paul M.D.

“…Linuron (3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea) is a herbicide that blocks androgen action in the male rat. Studies were undertaken to characterize the…”
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Altered Gene Expression During Rat Wolffian Duct Development following Di(n-Butyl) Phthalate Exposure by Bowman, Christopher J., Turner, Katie J., Sar, Madhabananda, Barlow, Norman J., Gaido, Kevin W., Foster, Paul M. D.

“…Di(n-butyl) phthalate (DBP) is a common plasticizer and solvent that disrupts androgen-dependent male reproductive development in rats. In utero exposure to…”
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Altered Gene Expression during Rat Wolffian Duct Development in Response to in Utero Exposure to the Antiandrogen Linuron by Turner, Katie J., McIntyre, Barry S., Phillips, Suzanne L., Barlow, Norman J., Bowman, Christopher J., Foster, Paul M. D.

“…Linuron is an herbicide with weak androgen receptor (AR) antagonist activity. Exposure to linuron from gestation days (GD) 12 to 21 perturbs androgen-dependent…”
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Transgenerational Effects of Di (2-Ethylhexyl) Phthalate in the Male CRL:CD(SD) Rat: Added Value of Assessing Multiple Offspring per Litter by Gray, Leon Earl, Barlow, Norman J., Howdeshell, Kembra L., Ostby, Joseph S., Furr, Johnathan R., Gray, Clark L.

“…In the rat, some phthalates alter sexual differentiation at relatively low dosage levels by altering fetal Leydig cell development and hormone synthesis,…”
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Pathogenesis of Male Reproductive Tract Lesions from Gestation Through Adulthood Following in Utero Exposure to Di(n-butyl) Phthalate by Barlow, Norman J., Foster, Paul M.D.

“…Di(n-butyl) phthalate (DBP) acts as an antiandrogen by decreasing fetal testicular testosterone synthesis when male rats are exposed in utero. DBPexposed male…”
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1060 Optimally engineered IL18 Fc-fusion proteins balance potency and pharmacokinetics to promote strong anti-tumor activity by Nisthal, Alex, Lee, Sung-Hyung, Bonzon, Christine, Love, Ruschelle, Avery, Kendra N, Rashid, Rumana, Lertkiatmongkol, Panida, Rodriguez, Nicole, Leung, Irene, Karki, Sher, Barlow, Norman J, Chu, Seung Y, Moore, Gregory L, Desjarlais, John R

“…BackgroundInterleukin-18 (IL18) promotes expansion, survival, and cytotoxicity of T and NK cells. Tumor-experienced T cells upregulate the heterodimeric IL18…”
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The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat by PARKS, Louise G, OSTBY, Joe S, LAMBRIGHT, Christy R, ABBOTT, Barbara D, KLINEFELTER, Gary R, BARLOW, Norman J, GRAY, L. Earl

“…Phthalate esters (PE) such as DEHP are high production volume plasticizers used in vinyl floors, food wraps, cosmetics, medical products, and toys. In spite of…”
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Quantitative Changes in Gene Expression in Fetal Rat Testes following Exposure to Di(n-butyl) Phthalate by Barlow, Norman J., Phillips, Suzanne L., Wallace, Duncan G., Sar, Madhabananda, Gaido, Kevin W., Foster, Paul M. D.

“…Di(n-butyl) phthalate (DBP) alters male reproductive development by decreasing testicular testosterone (T) production when fetuses are exposed on gestation…”
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Androgen-Mediated Development in Male Rat Offspring Exposed to Flutamide in Utero: Permanence and Correlation of Early Postnatal Changes in Anogenital Distance and Nipple Retention with Malformations in Androgen-Dependent Tissues by McIntyre, Barry S., Barlow, Norman J., Foster, Paul M. D.

“…Male offspring exposed in utero to antiandrogens often display alterations in androgen-dependent developmental markers (e.g., anogenital distance [AGD], nipple…”
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Recommended Approaches for the Evaluation of Testicular and Epididymal Toxicity by Lanning, Lynda L., Creasy, Dianne M., Chapin, Robert E., Mann, Peter C., Barlow, Norman J., Regan, Karen S., Goodman, Dawn G.

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Effects of in Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in the Male Rat by Bowman, Christopher J., Barlow, Norman J., Turner, Katie J., Wallace, Duncan G., Foster, Paul M. D.

“…Finasteride is a specific inhibitor of type II 5α-reductase, the enzyme that converts testosterone (T) to the more potent androgen receptor agonist…”
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Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that result in subsequent testicular atrophy by MCINTYRE, Barry S, BARLOW, Norman J, FOSTER, Paul M. D

“…Prenatal exposure to the herbicide linuron, a weak androgen receptor antagonist, has been shown to perturb androgen-dependent male rat reproductive development…”
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Effects of in Utero Exposure to the Organophosphate Insecticide Fenitrothion on Androgen-Dependent Reproductive Development in the Crl:CD(SD)BR Rat by Turner, Katie J., Barlow, Norman J., Struve, Melanie F., Wallace, Duncan G., Gaido, Kevin W., Dorman, David C., Foster, Paul M. D.

“…Fenitrothion [0,0-dimethyl-O-(4-nitro-m-tolyl) phosphorothioate] is an organophosphate insecticide that has been shown to have antiandrogenic activity using in…”
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Effects of in utero linuron exposure on rat Wolffian duct development by McIntyre, Barry S., Barlow, Norman J., Sar, Madhabananda, Wallace, Duncan G., Foster, Paul M.D.

“…Linuron is an herbicide that displays weak androgen receptor antagonist activity. Male offspring exposed in utero to 50 mg/kg/day linuron often exhibit…”
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The effect of commonly used vehicles on canine hematology and clinical chemistry values by Ruble, Gaye R, Giardino, Odessa Z, Fossceco, Stewart L, Cosmatos, Dennis, Knapp, Richard J, Barlow, Norman J

“…Drug metabolism and pharmacokinetic (DMPK) studies are an important phase in drug discovery research. Compounds are administered via the intravascular or…”
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Abstract 1880: PDL1-targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors by Moore, Gregory L., Zeng, Veronica, Diaz, Juan, Bonzon, Christine, Avery, Kendra N., Love, Ruschelle, Dragovich, Matthew, Rashid, Rumana, Hackett, Michael, Leung, Irene W., Qi, Jing, Bakhit, Charles G., Muchhal, Umesh S., Barlow, Norman J., Desjarlais, John R., Hedvat, Michael

“…T cells in the tumor micro-environment require TCR/MHC engagement and co-stimulatory receptor engagement to achieve complete activation. Tumor cells lack…”
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Abstract 1860: Bispecific claudin-6 x CD3 antibodies in a 2 + 1 format demonstrate selectivity and activity on human ovarian cancer cells by Faber, Matthew S., Lee, Sung-Hyung, Kim, Yoon Kyung, Qi, Jing, Avery, Kendra N., Nguyen, Duc-Hanh T., Rashid, Rumana, Eivazi, Araz, Chu, Seung Y., Diaz, Juan E., Ardila, Connie, Love, Ruschelle, Nisthal, Alex, Barlow, Norman J., Bonzon, Christine, Muchhal, Umesh S., Bernett, Matthew J., Desjarlais, John R.

“…There is a large unmet need for targeted therapies to treat ovarian cancer and other solid tumors. A promising strategy is the use of T cell engaging…”
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Recommended approaches for the evaluation of testicular and epididymal toxicity by LANNING, Lynda L, CREASY, Dianne M, CHAPIN, Robert E, MANN, Peter C, BARLOW, Norman J, REGAN, Karen S, GOODMAN, Dawn G

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