Search Results - "Barlow, Christopher K."

Lipidomics: Potential role in risk prediction and therapeutic monitoring for diabetes and cardiovascular disease by MEIKLE, Peter J, WONG, Gerard, BARLOW, Christopher K, KINGWELL, Bronwyn A

“…Lipidomics has developed rapidly over the past decade to the point where clinical application may soon be possible. Developments including high throughput…”
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Plasma Lipidomic Profiles Improve on Traditional Risk Factors for the Prediction of Cardiovascular Events in Type 2 Diabetes Mellitus by Alshehry, Zahir H, Mundra, Piyushkumar A, Barlow, Christopher K, Mellett, Natalie A, Wong, Gerard, McConville, Malcolm J, Simes, John, Tonkin, Andrew M, Sullivan, David R, Barnes, Elizabeth H, Nestel, Paul J, Kingwell, Bronwyn A, Marre, Michel, Neal, Bruce, Poulter, Neil R, Rodgers, Anthony, Williams, Bryan, Zoungas, Sophia, Hillis, Graham S, Chalmers, John, Woodward, Mark, Meikle, Peter J

“…BACKGROUND:Clinical lipid measurements do not show the full complexity of the altered lipid metabolism associated with diabetes mellitus or cardiovascular…”
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Plasma lipid profiling in a large population-based cohort[S] by Weir, Jacquelyn M., Wong, Gerard, Barlow, Christopher K., Greeve, Melissa A., Kowalczyk, Adam, Almasy, Laura, Comuzzie, Anthony G., Mahaney, Michael C., Jowett, Jeremy B.M., Shaw, Jonathan, Curran, Joanne E., Blangero, John, Meikle, Peter J.

“…We have performed plasma lipid profiling using liquid chromatography electrospray ionization tandem mass spectrometry on a population cohort of more than 1,000…”
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Plasma lipid profiling shows similar associations with prediabetes and type 2 diabetes by Meikle, Peter J, Wong, Gerard, Barlow, Christopher K, Weir, Jacquelyn M, Greeve, Melissa A, MacIntosh, Gemma L, Almasy, Laura, Comuzzie, Anthony G, Mahaney, Michael C, Kowalczyk, Adam, Haviv, Izhac, Grantham, Narelle, Magliano, Dianna J, Jowett, Jeremy B M, Zimmet, Paul, Curran, Joanne E, Blangero, John, Shaw, Jonathan

“…The relationship between lipid metabolism with prediabetes (impaired fasting glucose and impaired glucose tolerance) and type 2 diabetes mellitus is poorly…”
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Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution by Yap, Yann W., Rusu, Patricia M., Chan, Andrea Y., Fam, Barbara C., Jungmann, Andreas, Solon-Biet, Samantha M., Barlow, Christopher K., Creek, Darren J., Huang, Cheng, Schittenhelm, Ralf B., Morgan, Bruce, Schmoll, Dieter, Kiens, Bente, Piper, Matthew D. W., Heikenwälder, Mathias, Simpson, Stephen J., Bröer, Stefan, Andrikopoulos, Sofianos, Müller, Oliver J., Rose, Adam J.

“…Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise nutritional components driving this response remain elusive. Here, by…”
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Plasma Lipidomic Analysis of Stable and Unstable Coronary Artery Disease by Meikle, Peter J, Wong, Gerard, Tsorotes, Despina, Barlow, Christopher K, Weir, Jacquelyn M, Christopher, Michael J, MacIntosh, Gemma L, Goudey, Benjamin, Stern, Linda, Kowalczyk, Adam, Haviv, Izhak, White, Anthony J, Dart, Anthony M, Duffy, Stephen J, Jennings, Garry L, Kingwell, Bronwyn A

“…OBJECTIVE—Traditional risk factors for coronary artery disease (CAD) fail to adequately distinguish patients who have atherosclerotic plaques susceptible to…”
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A defined diet for pre-adult Drosophila melanogaster by Martelli, Felipe, Quig, Annelise, Mele, Sarah, Lin, Jiayi, Fulton, Tahlia L., Wansbrough, Mia, Barlow, Christopher K., Schittenhelm, Ralf B., Johnson, Travis K., Piper, Matthew D. W.

“…Drosophila melanogaster is unique among animal models because it has a fully defined synthetic diet available to study nutrient-gene interactions. However, use…”
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Plasmalogen modulation attenuates atherosclerosis in ApoE- and ApoE/GPx1-deficient mice by Rasmiena, Aliki A, Barlow, Christopher K, Stefanovic, Nada, Huynh, Kevin, Tan, Ricardo, Sharma, Arpeeta, Tull, Dedreia, de Haan, Judy B, Meikle, Peter J

“…Abstract Background and aim We previously reported a negative association of circulating plasmalogens (phospholipids with proposed atheroprotective properties)…”
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Epitopes in the capsular polysaccharide and the porin OmpK36 receptors are required for bacteriophage infection of Klebsiella pneumoniae by Dunstan, Rhys A., Bamert, Rebecca S., Tan, Kher Shing, Imbulgoda, Uvini, Barlow, Christopher K., Taiaroa, George, Pickard, Derek J., Schittenhelm, Ralf B., Dougan, Gordon, Short, Francesca L., Lithgow, Trevor

“…To kill bacteria, bacteriophages (phages) must first bind to a receptor, triggering the release of the phage DNA into the bacterial cell. Many bacteria secrete…”
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Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy by Casillas-Espinosa, Pablo M, Anderson, Alison, Harutyunyan, Anna, Li, Crystal, Lee, Jiyoon, Braine, Emma L, Brady, Rhys D, Sun, Mujun, Huang, Cheng, Barlow, Christopher K, Shah, Anup D, Schittenhelm, Ralf B, Mychasiuk, Richelle, Jones, Nigel C, Shultz, Sandy R, O'Brien, Terence J

“…There are no pharmacological disease-modifying treatments with an enduring effect to mitigate the seizures and comorbidities of established chronic temporal…”
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Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics by Martelli, Felipe, Lin, Jiayi, Mele, Sarah, Imlach, Wendy, Kanca, Oguz, Barlow, Christopher K., Paril, Jefferson, Schittenhelm, Ralf B., Christodoulou, John, Bellen, Hugo J., Piper, Matthew D.W., Johnson, Travis K.

“…Inherited metabolic disorders are a group of genetic conditions that can cause severe neurological impairment and child mortality. Uniquely, these disorders…”
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An Integrated Multi-Omic Network Analysis Identifies Seizure-Associated Dysregulated Pathways in the GAERS Model of Absence Epilepsy by Harutyunyan, Anna, Chong, Debbie, Li, Rui, Shah, Anup D, Ali, Zahra, Huang, Cheng, Barlow, Christopher K, Perucca, Piero, O'Brien, Terence J, Jones, Nigel C, Schittenhelm, Ralf B, Anderson, Alison, Casillas-Espinosa, Pablo M

“…Absence epilepsy syndromes are part of the genetic generalized epilepsies, the pathogenesis of which remains poorly understood, although a polygenic…”
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An Efficient Single Phase Method for the Extraction of Plasma Lipids by Alshehry, Zahir H, Barlow, Christopher K, Weir, Jacquelyn M, Zhou, Youping, McConville, Malcolm J, Meikle, Peter J

“…Lipidomic approaches are now widely used to investigate the relationship between lipid metabolism, health and disease. Large-scale lipidomics studies typically…”
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Arginine catabolism is essential to polymyxin dependence in Acinetobacter baumannii by Han, Mei-Ling, Alsaadi, Yasser, Zhao, Jinxin, Zhu, Yan, Lu, Jing, Jiang, Xukai, Ma, Wendong, Patil, Nitin A., Dunstan, Rhys A., Le Brun, Anton P., Wickremasinghe, Hasini, Hu, Xiaohan, Wu, Yimin, Yu, Heidi H., Wang, Jiping, Barlow, Christopher K., Bergen, Phillip J., Shen, Hsin-Hui, Lithgow, Trevor, Creek, Darren J., Velkov, Tony, Li, Jian

“…Polymyxins are often the only effective antibiotics against the “Critical” pathogen Acinetobacter baumannii. Worryingly, highly polymyxin-resistant…”
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Mechanistic Insights into the Capsule-Targeting Depolymerase from a Klebsiella pneumoniae Bacteriophage by Dunstan, Rhys A, Bamert, Rebecca S, Belousoff, Matthew J, Short, Francesca L, Barlow, Christopher K, Pickard, Derek J, Wilksch, Jonathan J, Schittenhelm, Ralf B, Strugnell, Richard A, Dougan, Gordon, Lithgow, Trevor

“…The production of capsular polysaccharides by Klebsiella pneumoniae protects the bacterial cell from harmful environmental factors such as antimicrobial…”
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Identification of Koala (Phascolarctos cinereus) Faecal Cortisol Metabolites Using Liquid Chromatography-Mass Spectrometry and Enzyme Immunoassays by Santamaria, Flavia, Barlow, Christopher, Schlagloth, Rolf, Schittenhelm, Ralf, Palme, Rupert, Henning, Joerg

“…The koala (Phascolarctos cinereus) is an arboreal folivorous marsupial endemic to Australia. Anthropogenic activities and climate change are threats to this…”
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Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance by Zhu, Yan, Lu, Jing, Han, Mei‐Ling, Jiang, Xukai, Azad, Mohammad A. K., Patil, Nitin A., Lin, Yu‐Wei, Zhao, Jinxin, Hu, Yang, Yu, Heidi H., Chen, Ke, Boyce, John D., Dunstan, Rhys A., Lithgow, Trevor, Barlow, Christopher K., Li, Weifeng, Schneider‐Futschik, Elena K., Wang, Jiping, Gong, Bin, Sommer, Bjorn, Creek, Darren J., Fu, Jing, Wang, Lushan, Schreiber, Falk, Velkov, Tony, Li, Jian

“…Multidrug‐resistant Acinetobacter baumannii is a top‐priority pathogen globally and polymyxins are a last‐line therapy. Polymyxin dependence in A. baumannii…”
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Circulating Lipids Are Associated with Alcoholic Liver Cirrhosis and Represent Potential Biomarkers for Risk Assessment by Meikle, Peter J, Mundra, Piyushkumar A, Wong, Gerard, Rahman, Khairunnessa, Huynh, Kevin, Barlow, Christopher K, Duly, Alastair M P, Haber, Paul S, Whitfield, John B, Seth, Devanshi

“…Liver disease is the greatest cause of death related to alcohol and a major public health problem. While excessive alcohol intake results in hepatosteatosis in…”
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Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii by Han, Mei-Ling, Liu, Xiaofen, Velkov, Tony, Lin, Yu-Wei, Zhu, Yan, Creek, Darren J, Barlow, Christopher K, Yu, Heidi H, Zhou, Zhihui, Zhang, Jing, Li, Jian

“…Polymyxins are a last-line class of antibiotics against multidrug-resistant . However, polymyxin resistance can emerge with monotherapy, highlighting the need…”
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Inclusion of plasma lipid species improves classification of individuals at risk of type 2 diabetes by Wong, Gerard, Barlow, Christopher K, Weir, Jacquelyn M, Jowett, Jeremy B M, Magliano, Dianna J, Zimmet, Paul, Shaw, Jonathan, Meikle, Peter J

“…A significant proportion of individuals with diabetes or impaired glucose tolerance have fasting plasma glucose less than 6.1 mmol/L and so are not identified…”
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