Search Results - "Barlocco, Daniela"

Romidepsin (FK228), A Histone Deacetylase Inhibitor and its Analogues in Cancer Chemotherapy by Pojani, Eftiola, Barlocco, Daniela

“…Human HDACs represent a group of enzymes able to modify histone and non-histone proteins, which interact with DNA to generate chromatin. The correlation…”
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Novel Antibacterial Agents 2022 by Meneghetti, Fiorella, Barlocco, Daniela

“…This Special Issue contains 16 original articles, 3 reviews, and 1 communication [...]…”
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Privileged structures as leads in medicinal chemistry by Costantino, Luca, Barlocco, Daniela

“…Among the strategies that can lead to the discovery of new drugs, the identification and use of privileged structures, molecular fragments that are able to…”
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Special Issue "Novel Antibacterial Agents" by Meneghetti, Fiorella, Barlocco, Daniela

“…This Special Issue of is devoted to significant advances achieved in the field of antibacterial agents [...]…”
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STAT 3 as a target for cancer drug discovery by Costantino, Luca, Barlocco, Daniela

“…Stat-3 (Signal Transduction and Activator of Transcription) is a member of the Stat family of latent, cytosolic transcription factors that directly relate…”
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Special Issue: Frontiers in Antimicrobial Drug Discovery and Design by Barlocco, Daniela, Meneghetti, Fiorella

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Iron Acquisition Pathways as Targets for Antitubercular Drugs by Meneghetti, Fiorella, Villa, Stefania, Gelain, Arianna, Barlocco, Daniela, Chiarelli, Laurent Roberto, Pasca, Maria Rosalia, Costantino, Luca

“…Tuberculosis nowadays ranks as the second leading cause of death from an infectious disease worldwide. In the last twenty years, this disease has again started…”
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Synthesis, Characterization, and Biological Evaluation of New Derivatives Targeting MbtI as Antitubercular Agents by Mori, Matteo, Stelitano, Giovanni, Chiarelli, Laurent R, Cazzaniga, Giulia, Gelain, Arianna, Barlocco, Daniela, Pini, Elena, Meneghetti, Fiorella, Villa, Stefania

“…Tuberculosis (TB) causes millions of deaths every year, ranking as one of the most dangerous infectious diseases worldwide. Because several pathogenic strains…”
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New Chromane-Based Derivatives as Inhibitors of Mycobacterium tuberculosis Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies by Pini, Elena, Poli, Giulio, Tuccinardi, Tiziano, Chiarelli, Laurent Roberto, Mori, Matteo, Gelain, Arianna, Costantino, Luca, Villa, Stefania, Meneghetti, Fiorella, Barlocco, Daniela

“…Tuberculosis is the leading cause of death from a single infectious agent worldwide; therefore, the need for new antitubercular drugs is desperate. The…”
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Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy by Masciocchi, Daniela, Gelain, Arianna, Villa, Stefania, Meneghetti, Fiorella, Barlocco, Daniela

“…Signal transducer and activator of transcription 3 (STAT3) is an oncogenic protein whose inhibition is sought for the prevention and treatment of cancer. In…”
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New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents by Chiarelli, Laurent R., Mori, Matteo, Beretta, Giangiacomo, Gelain, Arianna, Pini, Elena, Sammartino, Josè Camilla, Stelitano, Giovanni, Barlocco, Daniela, Costantino, Luca, Lapillo, Margherita, Poli, Giulio, Caligiuri, Isabella, Rizzolio, Flavio, Bellinzoni, Marco, Tuccinardi, Tiziano, Villa, Stefania, Meneghetti, Fiorella

“…Starting from the analysis of the hypothetical binding mode of our previous furan-based hit (I), we successfully achieved our objective to replace the nitro…”
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Synthesis of new dithiolethione and methanethiosulfonate systems endowed with pharmaceutical interest by Gabriele, Elena, Porta, Federica, Facchetti, Giorgio, Galli, Corinna, Gelain, Arianna, Meneghetti, Fiorella, Rimoldi, Isabella, Romeo, Sergio, Villa, Stefania, Ricci, Chiara, Ferri, Nicola, Asai, Akira, Barlocco, Daniela, Sparatore, Anna

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Structure−Activity Studies and Analgesic Efficacy of N-(3-Pyridinyl)-Bridged Bicyclic Diamines, Exceptionally Potent Agonists at Nicotinic Acetylcholine Receptors by Bunnelle, William H, Daanen, Jerome F, Ryther, Keith B, Schrimpf, Michael R, Dart, Michael J, Gelain, Arianna, Meyer, Michael D, Frost, Jennifer M, Anderson, David J, Buckley, Michael, Curzon, Peter, Cao, Ying-Jun, Puttfarcken, Pamela, Searle, Xenia, Ji, Jianguo, Putman, C. Brent, Surowy, Carol, Toma, Lucio, Barlocco, Daniela

“…A series of exceptionally potent agonists at neuronal nicotinic acetylcholine receptors (nAChRs) has been investigated. Several N-(3-pyridinyl) derivatives of…”
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Teaching an Undergraduate Organic Chemistry Laboratory Course with a Tailored Problem-Based Learning Approach by Costantino, Luca, Barlocco, Daniela

“…This article presents the structure of the organic chemistry laboratory Course “Synthesis and Extraction of Drugs” that is included in Modena University…”
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Synthesis, Screening, and Molecular Modeling of New Potent and Selective Antagonists at the α1d Adrenergic Receptor by Leonardi, Amedeo, Barlocco, Daniela, Montesano, Federica, Cignarella, Giorgio, Motta, Gianni, Testa, Rodolfo, Poggesi, Elena, Seeber, Michele, De Benedetti, Pier G., Fanelli, Francesca

“…In the present study, more than 75 compounds structurally related to BMY 7378 have been designed and synthesized. Structural variations of each part of the…”
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Inhibitors for proteins endowed with catalytic and non-catalytic activity which recognize pTyr by Costantino, Luca, Barlocco, Daniela

“…Reversible phosphorylation of Tyr residues in proteins plays a central role in the transduction of signals. For both SH2 domains and for protein tyrosine…”
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Ten Years of Medicinal Chemistry (2005–2014) in the Journal of Medicinal Chemistry: Country of Contributors, Topics, and Public–Private Partnerships: Miniperspective by Costantino, Luca, Barlocco, Daniela

“…This review analyzes the articles that have appeared during the past 10 years in the Journal of Medicinal Chemistry, the leading journal in the field of…”
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An HTS FP assay able to selectively identify STAT3-DBD inhibitors by Meneghetti, Fiorella, Barlocco, Daniela

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Synthesis, Activity, and Molecular Modeling of a New Series of Tricyclic Pyridazinones as Selective Aldose Reductase Inhibitors by Costantino, Luca, Rastelli, Giulio, Vescovini, Katia, Cignarella, Giorgio, Vianello, Paola, Del Corso, Antonella, Cappiello, Mario, Mura, Umberto, Barlocco, Daniela

“…Three new series of tricyclic pyridazinones have been synthesized and tested in vitro in order to assess (i) their ability to inhibit aldose reductase enzyme…”
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Ten Years of Medicinal Chemistry (2005-2014) in the Journal of Medicinal Chemistry: Country of Contributors, Topics, and Public-Private Partnerships by Costantino, Luca, Barlocco, Daniela

“…This review analyzes the articles that have appeared during the past 10 years in the Journal of Medicinal Chemistry, the leading journal in the field of…”
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