Search Results - "Barlocco, D."

Designed multiple ligands: basic research vs clinical outcomes by Costantino, L, Barlocco, D

“…The clinical treatment of multifactorial pathologies (e.g. cancer, Alzheimer's disease, psychiatric disorders), is still a major challenge. Many researches…”
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Semicarbazide-sensitive amine oxidase/vascular adhesion protein 1: recent developments concerning substrates and inhibitors of a promising therapeutic target by Dunkel, P, Gelain, A, Barlocco, D, Haider, N, Gyires, K, Sperlágh, B, Magyar, K, Maccioni, E, Fadda, A, Mátyus, P

“…SSAO/VAP-1 is not only involved in the metabolism of biogenic and xenobiotic primary amines and in the production of metabolites with cytotoxic effects or…”
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Thymidylate synthase structure, function and implication in drug discovery by Costi, M P, Ferrari, S, Venturelli, A, Calò, S, Tondi, D, Barlocco, D

“…Recent methodologies applied to the drug discovery process, such as genomics and proteomics, have greatly implemented our basic understanding of drug action…”
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Semicarbazide-sensitive amine oxidase: current status and perspectives by Mátyus, P, Dajka-Halász, B, Földi, A, Haider, N, Barlocco, D, Magyar, K

“…Semicarbazide-sensitive amine-oxidase (SSAO) is present in various human tissues and in plasma. Oxidative deamination of short-chain aliphatic amines is…”
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Selective ACAT inhibitors as promising antihyperlipidemic, antiathero-sclerotic and anti-Alzheimer drugs by Giovannoni, M P, Piaz, V Dal, Vergelli, C, Barlocco, D

“…Inhibition of ACAT, the enzyme which catalyses the intracellular formation of cholesteryl esters, is a very attractive target for the treatment of…”
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Versatility of the pyridazine system: Chemistry and biology by Cignarella, G., Barlocco, D.

“…In accordance with the title of my lecture, I am going to briefly illustrate our researches on pyridazine derivatives active in different biological areas…”
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Non peptidic ligands at the opioid receptor like-1 (ORL-1) by Barlocco, D, Toma, L, Cignarella, G

“…Opioid receptor like-1 (ORL-1) has recently been indicated as a potentially useful target for the treatment of a number of central disorders and several other…”
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Privileged structures as leads in medicinal chemistry by Costantino, Luca, Barlocco, Daniela

“…Among the strategies that can lead to the discovery of new drugs, the identification and use of privileged structures, molecular fragments that are able to…”
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5,6-Diphenylpyridazine Derivatives as Acyl-CoA:Cholesterol Acyltransferase Inhibitors by Giovannoni, Maria Paola, Piaz, Vittorio Dal, Kwon, Byoung-Mog, Kim, Mi-Kyung, Kim, Young-Kook, Toma, Lucio, Barlocco, Daniela, Bernini, Franco, Canavesi, Monica

“…Alkyl-5,6-diphenylpyridazine derivatives combining several main features of ACAT inhibitors, such as a long alkyl side chain linked to a heterocycle and the…”
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The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics by Barlocco, Daniela, Cignarella, Giorgio, Giardina, Giuseppe A.M, Toma, Lucio

“…Anew sequence, which encoded a novel G protein-coupled receptor, was disclosed by two different groups, using the nucleic acid probes based on the delta opioid…”
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4,5-Functionalized 6-phenyl-3(2 H)-pyridazinones: synthesis and evaluation of antinociceptive activity by Dal Piaz, V, Giovannoni, MP, Ciciani, G, Barlocco, D, Giardina, G, Petrone, G, Clarke, GD

“…A series of 2-substituted 4,5-functionalized 6-phenyl-3(2 H)-pyridazinones were synthesized and their antinociceptive activities were evaluated in the mouse…”
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Characterization and pharmacological actions of tecostanine, an alkaloid of Tecoma stans by Costantino, L, Lins, A P, Barlocco, D, Celotti, F, el-Abady, S A, Brunetti, T, Maggi, R, Antolini, L

“…Tecostanine (1) was isolated from Tecoma stans leaves. Its sterochemistry was elucidated as well as its antihyperglycemic activity and its affinity to opioid…”
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Monitor by Barlocco, D

“…The need for new and effective antimalarial drugs is high…”
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STUDY OF THE ANTISECRETORY AND ANTIULCER MECHANISMS OF A NEW INDENOPIRYDAZINONE DERIVATIVE IN RATS by BAROCELLI, E, CHIAVARINI, M, BALLABENI, V, BARLOCCO, D, VIANELLO, P, DAL PIAZ, V, IMPICCIATORE, M

“…The present study investigates the antisecretory and antiulcer mechanisms of a new indenopyridazinone derivative previously reported to inhibit gastric acid…”
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A novel antifungal anthraquinone from Saprosma fragrans by Barlocco, Daniela

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A new anti-inflammatory spirolactone derivative from Dendrobium chrysanthum by Barlocco, Daniela

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A novel selective inhibitor of the phosphodiesterase type 2 isozyme by Barlocco, Daniela

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Monitor – chemistry by Barlocco, Daniela

“…An insight into the latest developments in drug discovery through brief synopses of recent publications, summarizing the chemistry, pharmacological…”
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Naphthalimido derivatives as antifolate thymidylate synthase inhibitors by Costi, MP, Tondi, D, Rinaldi, M, Barlocco, D, Cignarella, G, Santi, DV, Musiu, C, Pudu, I, Vacca, G, La Colla, P

“…A new series of N-(substituted)benzyl-1,8-naphthalimides 4, structurally related to the previously reported thymidylate synthase (TS) inhibitor naphthaleins 3,…”
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Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches by Costantino, Luca, Rastelli, Giulio, Vianello, Paola, Cignarella, Giorgio, Barlocco, Daniela

“…Despite recent advances both in the chemistry and molecular pharmacology of antidiabetic drugs, diabetes still remains a life‐threatening disease, which tends…”
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