Search Results - "Barkhof, F"

Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer’s Disease by Budd Haeberlein, Samantha, Aisen, P.S., Barkhof, F., Chalkias, S., Chen, T., Cohen, S., Dent, G., Hansson, O., Harrison, K., von Hehn, C., Iwatsubo, T., Mallinckrodt, C., Mummery, C.J., Muralidharan, K.K., Nestorov, I., Nisenbaum, L., Rajagovindan, R., Skordos, L., Tian, Y., van Dyck, C.H., Vellas, B., Wu, S., Zhu, Y., Sandrock, A.

“…Background Alzheimer’s disease is a progressive, irreversible, and fatal disease for which accumulation of amyloid beta is thought to play a key role in…”
Get full text

Consistent Resting-State Networks across Healthy Subjects by Damoiseaux, J. S., Rombouts, S. A. R. B., Barkhof, F., Scheltens, P., Stam, C. J., Smith, S. M., Beckmann, C. F.

“…Functional MRI (fMRI) can be applied to study the functional connectivity of the human brain. It has been suggested that fluctuations in the blood oxygenation…”
Get full text

Reduced resting-state brain activity in the “default network” in normal aging by Damoiseaux, J.S., Beckmann, C.F., Arigita, E.J. Sanz, Barkhof, F., Scheltens, Ph, Stam, C.J., Smith, S.M., Rombouts, S.A.R.B.

“…Normal aging is associated with cognitive decline. Functions such as attention, information processing, and working memory are compromised. It has been…”
Get full text

Amyloid-Related Imaging Abnormalities with Emerging Alzheimer Disease Therapeutics: Detection and Reporting Recommendations for Clinical Practice by Cogswell, P M, Barakos, J A, Barkhof, F, Benzinger, T S, Jack, Jr, C R, Poussaint, T Y, Raji, C A, Ramanan, V K, Whitlow, C T

“…Monoclonal antibodies are emerging disease-modifying therapies for Alzheimer disease that require brain MR imaging for eligibility assessment as well as for…”
Get full text

Bidirectional trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis by Balk, L J, Steenwijk, M D, Tewarie, P, Daams, M, Killestein, J, Wattjes, M P, Vrenken, H, Barkhof, F, Polman, C H, Uitdehaag, B M J, Petzold, A

“…Objective To investigate the coexistence of anterograde and retrograde trans-synaptic axonal degeneration, and to explore the relationship between selective…”
Get full text

Global Burden of Small Vessel Disease–Related Brain Changes on MRI Predicts Cognitive and Functional Decline by Jokinen, Hanna, Koikkalainen, Juha, Laakso, Hanna M., Melkas, Susanna, Nieminen, Tuomas, Brander, Antti, Korvenoja, Antti, Rueckert, Daniel, Barkhof, Frederik, Scheltens, Philip, Schmidt, Reinhold, Fazekas, Franz, Madureira, Sofia, Verdelho, Ana, Wallin, Anders, Wahlund, Lars-Olof, Waldemar, Gunhild, Chabriat, Hugues, Hennerici, Michael, O’Brien, John, Inzitari, Domenico, Lötjönen, Jyrki, Pantoni, Leonardo, Erkinjuntti, Timo

“…BACKGROUND AND PURPOSE—Cerebral small vessel disease is characterized by a wide range of focal and global brain changes. We used a magnetic resonance imaging…”
Get full text

Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis by Granziera, Cristina, Wuerfel, Jens, Barkhof, Frederik, Calabrese, Massimiliano, De Stefano, Nicola, Enzinger, Christian, Evangelou, Nikos, Filippi, Massimo, Geurts, Jeroen J G, Reich, Daniel S, Rocca, Maria A, Ropele, Stefan, Rovira, Àlex, Sati, Pascal, Toosy, Ahmed T, Vrenken, Hugo, Gandini Wheeler-Kingshott, Claudia A M, Kappos, Ludwig

“…Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS, which can be compared across CNS regions, patients, and centres. In…”
Get full text

Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes by DE STEFANO, N, GIORGIO, A, DINACCI, D, TEDESCHI, G, GASS, A, MONTALBAN, X, ROVIRA, A, THOMPSON, A, COMI, G, MILLER, D. H, FILIPPI, M, BATTAGLINI, M, ROVARIS, M, SORMANI, M. P, BARKHOF, F, KORTEWEG, T, ENZINGER, C, FAZEKAS, F, CALABRESE, M

“…To assess the time course of brain atrophy and the difference across clinical subtypes in multiple sclerosis (MS). The percent brain volume change (PBVC) was…”
Get full text

Inter-rater agreement in glioma segmentations on longitudinal MRI by Visser, M, Müller, D M J, van Duijn, R J M, Smits, M, Verburg, N, Hendriks, E J, Nabuurs, R J A, Bot, J C J, Eijgelaar, R S, Witte, M, van Herk, M B, Barkhof, F, de Witt Hamer, P C, de Munck, J C

“…Tumor segmentation of glioma on MRI is a technique to monitor, quantify and report disease progression. Manual MRI segmentation is the gold standard but very…”
Get full text

Enlarged Virchow-Robin spaces: do they matter? by Barkhof, F

Get full text

Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid proteomics by Tijms, Betty M, Gobom, Johan, Reus, Lianne, Jansen, Iris, Hong, Shengjun, Dobricic, Valerija, Kilpert, Fabian, Ten Kate, Mara, Barkhof, Frederik, Tsolaki, Magda, Verhey, Frans R J, Popp, Julius, Martinez-Lage, Pablo, Vandenberghe, Rik, Lleó, Alberto, Molinuevo, José Luís, Engelborghs, Sebastiaan, Bertram, Lars, Lovestone, Simon, Streffer, Johannes, Vos, Stephanie, Bos, Isabelle, Blennow, Kaj, Scheltens, Philip, Teunissen, Charlotte E, Zetterberg, Henrik, Visser, Pieter Jelle

“…Alzheimer's disease is biologically heterogeneous, and detailed understanding of the processes involved in patients is critical for development of treatments…”
Get full text

Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort by Inzitari, Domenico, Pracucci, Giovanni, Poggesi, Anna, Carlucci, Giovanna, Barkhof, Frederik, Chabriat, Hugues, Erkinjuntti, Timo, Fazekas, Franz, Ferro, José M, Hennerici, Michael, Langhorne, Peter, O’Brien, John, Scheltens, Philip, Visser, Marieke C, Wahlund, Lars-Olof, Waldemar, Gunhild, Wallin, Anders, Pantoni, Leonardo

“…Objective To assess the impairment in daily living activities in older people with age related changes in white matter according to the severity of these…”
Get full text

Prevalence and severity of microbleeds in a memory clinic setting by CORDONNIER, C, VAN DER FLIER, W. M, SLUIMER, J. D, LEYS, D, BARKHOF, F, SCHELTENS, P

“…To determine prevalence and severity of microbleeds (MBs) in a large cohort of patients attending a memory clinic. The authors consecutively included patients…”
Get full text

Dementia imaging in clinical practice: a European-wide survey of 193 centres and conclusions by the ESNR working group by Vernooij, M. W., Pizzini, F. B., Schmidt, R., Smits, M., Yousry, T. A., Bargallo, N., Frisoni, G. B., Haller, S., Barkhof, F.

“…Purpose Through a European-wide survey, we assessed the current clinical practice of imaging in the primary evaluation of dementia, with respect to…”
Get full text

Optimizing parameter choice for FSL-Brain Extraction Tool (BET) on 3D T1 images in multiple sclerosis by Popescu, V., Battaglini, M., Hoogstrate, W.S., Verfaillie, S.C.J., Sluimer, I.C., van Schijndel, R.A., van Dijk, B.W., Cover, K.S., Knol, D.L., Jenkinson, M., Barkhof, F., de Stefano, N., Vrenken, H.

“…Brain atrophy studies often use FSL-BET (Brain Extraction Tool) as the first step of image processing. Default BET does not always give satisfactory results on…”
Get full text

Brain reward-system activation in response to anticipation and consumption of palatable food is altered by glucagon-like peptide-1 receptor activation in humans by van Bloemendaal, L., Veltman, D. J., ten Kulve, J. S., Groot, P. F. C., Ruhé, H. G., Barkhof, F., Sloan, J. H., Diamant, M., Ijzerman, R. G.

“…Aim To test the hypothesis that food intake reduction after glucagon‐like peptide‐1 (GLP‐1) receptor activation is mediated through brain areas regulating…”
Get full text

rTMS affects working memory performance, brain activation and functional connectivity in patients with multiple sclerosis by Hulst, H E, Goldschmidt, T, Nitsche, M A, de Wit, S J, van den Heuvel, O A, Barkhof, F, Paulus, W, van der Werf, Y D, Geurts, J J G

“…ObjectiveTo investigate the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) of the right dorsolateral prefrontal cortex (DLPFC)…”
Get full text

Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes by KAPPOS, L, POLMAN, C. H, POHL, C, SANDBRINK, R, FREEDMAN, M. S, EDAN, G, HARTUNG, H. P, MILLER, D. H, MONTALBAN, X, BARKHOF, F, BAUER, L, JAKOBS, P

“…To assess efficacy, safety, and tolerability of every-other-day interferon beta-1b treatment in patients with a first clinical event suggestive of multiple…”
Get full text

Postmortem verification of MS cortical lesion detection with 3D DIR by SEEWANN, A, KOOI, E.-J, ROOSENDAAL, S. D, POUWELS, P. J. W, WATTJES, M. P, VAN DER VALK, P, BARKHOF, F, POLMAN, C. H, GEURTS, J. J. G

“…To assess the sensitivity and specificity of 3D double inversion recovery (DIR) MRI for detecting multiple sclerosis (MS) cortical lesions (CLs) using a direct…”
Get full text

An algorithmic approach to structural imaging in dementia by Harper, Lorna, Barkhof, Frederik, Scheltens, Philip, Schott, Jonathan M, Fox, Nick C

“…Accurate and timely diagnosis of dementia is important to guide management and provide appropriate information and support to patients and families. Currently,…”
Get full text