Search Results - "Barker, Tolga"

Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane by Barker, Tolga T, Lee, Pui Y, Kelly-Scumpia, Kindra M, Weinstein, Jason S, Nacionales, Dina C, Kumagai, Yutaro, Akira, Shizuo, Croker, Byron P, Sobel, Eric S, Reeves, Westley H, Satoh, Minoru

“…Diffuse alveolar hemorrhage is an uncommon, yet often fatal, complication of systemic lupus erythematosus (SLE). Advances in the treatment of alveolar…”
Get full text

Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists by Wynn, James L., Scumpia, Philip O., Winfield, Robert D., Delano, Matthew J., Kelly-Scumpia, Kindra, Barker, Tolga, Ungaro, Ricardo, Levy, Ofer, Moldawer, Lyle L.

“…Neonates exhibit an increased risk of sepsis mortality compared with adults. We show that in contrast to adults, survival from polymicrobial sepsis in murine…”
Get full text

Cloning and characterization of a hybridoma secreting a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-specific monoclonal antibody and recombinant F(ab) by Wanczyk, Heather, Barker, Tolga, Rood, Debra, Zapata, Daniel I, Howell, Amy R, Richardson, Stewart K, Zinckgraf, John, Marusov, Gregory P, Lynes, Michael A, Silbart, Lawrence K

“…Smokeless tobacco products have been associated with increased risks of oro-pharyngeal cancers, due in part to the presence of tobacco-specific nitrosamines…”
Get full text

Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases by Yamasaki, Yoshioki, Narain, Sonali, Hernandez, Liza, Barker, Tolga, Ikeda, Keigo, Segal, Mark S, Richards, Hanno B, Chan, Edward K L, Reeves, Westley H, Satoh, Minoru

“…Replication protein A (RPA), a heterotrimer with subunits of molecular masses 70, 32, and 14 kDa, is a single-stranded-DNA-binding factor involved in DNA…”
Get full text

Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c mice by Kuroda, Yoshiki, Ono, Nobutaka, Akaogi, Jun, Nacionales, Dina C., Yamasaki, Yoshioki, Barker, Tolga T., Reeves, Westley H., Satoh, Minoru

“…A single intraperitoneal (i.p.) injection of pristane, incomplete Freund's adjuvant (IFA), or the adjuvant oil squalene, but not high molecular weight…”
Get full text

High affinity binding site-mediated prevention of chemical absorption across the gastrointestinal tract by Rasmussen, Max V, Barker, Tolga T, Silbart, Lawrence K

“…Preventing mucosal absorption of low-molecular weight compounds such as carcinogens, toxins and drugs could help prevent many diseases. To characterize the…”
Get full text

TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus by Lee, Pui Y., Kumagai, Yutaro, Li, Yi, Takeuchi, Osamu, Yoshida, Hideo, Weinstein, Jason, Kellner, Erinn S., Nacionales, Dina, Barker, Tolga, Kelly-Scumpia, Kindra, van Rooijen, Nico, Kumar, Himanshu, Kawai, Taro, Satoh, Minoru, Akira, Shizuo, Reeves, Westley H.

“…Increased type I interferon (IFN-I) production and IFN-stimulated gene (ISG) expression are linked to the pathogenesis of systemic lupus erythematosus (SLE)…”
Get full text

Naive T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel TH2 immunity by Liang, Genqing, Barker, Tolga, Xie, Zhihui, Charles, Nicolas, Rivera, Juan, Druey, Kirk M.

“…Sensitization to protease allergens, such as papain, or helminth infection is associated with basophil recruitment to draining lymph nodes (LNs). Basophils…”
Get full text

Regulator of G protein signaling 5 restricts neutrophil chemotaxis and trafficking by Chan, Eunice C., Ren, Chunguang, Xie, Zhihui, Jude, Joseph, Barker, Tolga, Koziol-White, Cynthia A., Ma, Michelle, Panettieri, Reynold A., Wu, Dianqing, Rosenberg, Helene F., Druey, Kirk M.

“…Neutrophils are white blood cells that are mobilized to damaged tissues and to sites of pathogen invasion, providing the first line of host defense. Chemokines…”
Get full text

IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil by Lee, Pui Y, Kumagai, Yutaro, Xu, Yuan, Li, Yi, Barker, Tolga, Liu, Chao, Sobel, Eric S, Takeuchi, Osamu, Akira, Shizuo, Satoh, Minoru, Reeves, Westley H

“…Exposure to naturally occurring hydrocarbon oils is associated with the development of chronic inflammation and a wide spectrum of pathological findings in…”
Get full text

Eosinophil-associated Ribonuclease 11 Is a Macrophage Chemoattractant by Yamada, Kelsey J., Barker, Tolga, Dyer, Kimberly D., Rice, Tyler A., Percopo, Caroline M., Garcia-Crespo, Katia E., Cho, Soochin, Lee, James J., Druey, Kirk M., Rosenberg, Helene F.

“…RNase A is the prototype of an extensive family of divergent proteins whose members share a unique disulfide-bonded tertiary structure, conserved catalytic…”
Get full text

Naïve T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel T helper type 2 immunity by Liang, Genqing, Barker, Tolga, Xie, Zhihui, Charles, Nicolas, Rivera, Juan, Druey, Kirk M.

Get full text

Increased Natural CD4+CD25+ Regulatory T Cells and Their Suppressor Activity Do Not Contribute to Mortality in Murine Polymicrobial Sepsis by Scumpia, Philip O, Delano, Matthew J, Kelly, Kindra M, O'Malley, Kerri A, Efron, Philip A, McAuliffe, Priscilla F, Brusko, Todd, Ungaro, Ricardo, Barker, Tolga, Wynn, James L, Atkinson, Mark A, Reeves, Westley H, Clare Salzler, Michael J, Moldawer, Lyle L

“…Regulatory T cells (Tregs), including natural CD4+CD25+ Tregs and inducible IL-10 producing T regulatory type 1 (T(R)1) cells, maintain tolerance and inhibit…”
Get full text

Naive T cells sense the cysteine protease allergen papain through protease-activated receptor 2 and propel TH 2 immunity by Liang, Genqing, PhD, Barker, Tolga, PhD, Xie, Zhihui, PhD, Charles, Nicolas, PhD, Rivera, Juan, PhD, Druey, Kirk M., MD

“…Background Sensitization to protease allergens, such as papain, or helminth infection is associated with basophil recruitment to draining lymph nodes (LNs)…”
Get full text

Autoantibodies to RNA helicase A: A new serologic marker of early lupus by Yamasaki, Yoshioki, Narain, Sonali, Yoshida, Hideo, Hernandez, Liza, Barker, Tolga, Hahn, Paulette C., Sobel, Eric S., Segal, Mark S., Richards, Hanno B., Chan, Edward K. L., Reeves, Westley H., Satoh, Minoru

“…Objective To investigate the clinical and immunologic significance of autoantibodies to RNA helicase A (RHA) in patients with systemic rheumatic diseases…”
Get full text

Role of non-protein amino acid l-canavanine in autoimmunity by Akaogi, Jun, Barker, Tolga, Kuroda, Yoshiki, Nacionales, Dina C., Yamasaki, Yoshioki, Stevens, Bruce R., Reeves, Westley H., Satoh, Minoru

“…Association of SLE and alfalfa was first reported in a volunteer who developed lupus-like autoimmunity while ingesting alfalfa seed for a hypercholesterolemia…”
Get full text

Interleukin-1 alpha modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil1 by Lee, Pui Y., Kumagai, Yutaro, Xu, Yuan, Li, Yi, Barker, Tolga, Liu, Chao, Sobel, Eric S., Takeuchi, Osamu, Akira, Shizuo, Satoh, Minoru, Reeves, WestleyH

“…Exposure to naturally-occurring hydrocarbon oils is associated with the development of chronic inflammation and a wide spectrum of pathological findings in…”
Get full text

Peptide-Pulsed Immature Dendritic Cells Reduce Response to β Cell Target Antigens and Protect NOD Recipients from Type I Diabetes by LO, JEANNETTE, PENG, RUI HUA, BARKER, TOLGA, XIA, CHANG-QING, CLARE-SALZLER, MICHAEL J.

“…:  Our previous work demonstrated peptide‐pulsed mature myeloid dendritic cells (DC) presenting β cell antigens induce tolerance. Here we determine whether…”
Get full text

Pristane‐induced alveolar hemorrhage in C57BL/6 mice is not mediated by immune complex, T or B‐cells, or Fas by Barker, Tolga, Lee, Pui Y., Weinstein, Jason S., Nacionales, Dina C., Kelly‐Scumpia, Kindra M., Sobel, Eric S., Reeves, Westley H., Satoh, Minoru

“…Abstract only Intraperitoneal (ip) injection of pristane in normal mice induces antinuclear antibodies and immune‐complex (IC) glomerulonephritis similar to…”
Get full text

The role of B-cell subsets in pristane-induced lupus (130.14) by Barker, Tolga, Lee, Pui Y., Weinstein, Jason, Nacionales, Dina C., Kelly-Scumpia, Kindra M., Sobel, Eric S., Reeves, Westley H., Satoh, Minoru

“…An intraperitoneal (ip) injection of pristane in mice induces a biphasic immune response characterized by an early T-independent phase (increased total IgM,…”
Get full text