Search Results - "Barker, Jonathan N."

Psoriasis by Griffiths, Christopher E M, Armstrong, April W, Gudjonsson, Johann E, Barker, Jonathan N W N

“…Psoriasis is a common, chronic papulosquamous skin disease occurring worldwide, presenting at any age, and leading to a substantial burden for individuals and…”
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Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects by Saunders, Sean P., PhD, Goh, Christabelle S.M., BSc, Brown, Sara J., MD, Palmer, Colin N.A., PhD, Porter, Rebecca M., PhD, Cole, Christian, PhD, Campbell, Linda E., MSc, Gierlinski, Marek, PhD, Barton, Geoffrey J., PhD, Schneider, Georg, PhD, Balmain, Allan, PhD, Prescott, Alan R., PhD, Weidinger, Stephan, MD, PhD, Baurecht, Hansjörg, PhD, Kabesch, Michael, MD, Gieger, Christian, PhD, Lee, Young-Ae, MD, Tavendale, Roger, PhD, Mukhopadhyay, Somnath, MD, Turner, Stephen W., MD, Madhok, Vishnu B., MD, Sullivan, Frank M., MD, Relton, Caroline, PhD, Burn, John, MD, Meggitt, Simon, MD, Smith, Catherine H., MD, Allen, Michael A., PhD, Barker, Jonathan N.W. N., MD, Reynolds, Nick J., MD, Cordell, Heather J., DPhil, Irvine, Alan D., MD, McLean, W.H. Irwin, DSc, Sandilands, Aileen, PhD, Fallon, Padraic G., PhD

“…Background Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin…”
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Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis Identifies Seven Shared Susceptibility Loci by Ellinghaus, David, Ellinghaus, Eva, Nair, Rajan P., Stuart, Philip E., Esko, Tõnu, Metspalu, Andres, Debrus, Sophie, Raelson, John V., Tejasvi, Trilokraj, Belouchi, Majid, West, Sarah L., Barker, Jonathan N., Kõks, Sulev, Kingo, Külli, Balschun, Tobias, Palmieri, Orazio, Annese, Vito, Gieger, Christian, Wichmann, H. Erich, Kabesch, Michael, Trembath, Richard C., Mathew, Christopher G., Abecasis, Gonçalo R., Weidinger, Stephan, Nikolaus, Susanna, Schreiber, Stefan, Elder, James T., Weichenthal, Michael, Nothnagel, Michael, Franke, Andre

“…Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically, and therapeutically connected, but little is known about their…”
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Psoriasis and Genetics by Dand, Nick, Mahil, Satveer K, Capon, Francesca, Smith, Catherine H, Simpson, Michael A, Barker, Jonathan N

“…Psoriasis is a common inflammatory skin disease caused by the interplay between multiple genetic and environmental risk factors. This review summarises recent…”
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Mutations in IL36RN/IL1F5 Are Associated with the Severe Episodic Inflammatory Skin Disease Known as Generalized Pustular Psoriasis by Onoufriadis, Alexandros, Simpson, Michael A., Pink, Andrew E., Di Meglio, Paola, Smith, Catherine H., Pullabhatla, Venu, Knight, Jo, Spain, Sarah L., Nestle, Frank O., Burden, A. David, Capon, Francesca, Trembath, Richard C., Barker, Jonathan N.

“…Generalized pustular psoriasis (GPP) is a rare and yet potentially lethal clinical variant of psoriasis, characterized by the formation of sterile cutaneous…”
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Comparison of Drug Discontinuation, Effectiveness, and Safety Between Clinical Trial Eligible and Ineligible Patients in BADBIR by Mason, Kayleigh J, Barker, Jonathan N W N, Smith, Catherine H, Hampton, Philip J, Lunt, Mark, McElhone, Kathleen, Warren, Richard B, Yiu, Zenas Z N, Griffiths, Christopher E M, Burden, A David

“…Patients with psoriasis enrolled in clinical trials of biologics may not be representative of the real-world population. There is evidence that patients…”
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Single-cell analysis of psoriasis resolution demonstrates an inflammatory fibroblast state targeted by IL-23 blockade by Francis, Luc, McCluskey, Daniel, Ganier, Clarisse, Jiang, Treasa, Du-Harpur, Xinyi, Gabriel, Jeyrroy, Dhami, Pawan, Kamra, Yogesh, Visvanathan, Sudha, Barker, Jonathan N., Smith, Catherine H., Capon, Francesca, Mahil, Satveer K.

“…Biologic therapies targeting the IL-23/IL-17 axis have transformed the treatment of psoriasis. However, the early mechanisms of action of these drugs remain…”
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Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid Conditions by Davidovici, Batya B., Sattar, Naveed, Jörg, Prinz C., Puig, Luis, Emery, Paul, Barker, Jonathan N., van de Kerkhof, Peter, Ståhle, Mona, Nestle, Frank O., Girolomoni, Giampiero, Krueger, James G.

“…Psoriasis is now classified as an immune-mediated inflammatory disease (IMID) of the skin. It is being recognized that patients with various IMIDs, including…”
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Single-cell analysis implicates TH17-to-TH2 cell plasticity in the pathogenesis of palmoplantar pustulosis by McCluskey, Daniel, Benzian-Olsson, Natashia, Mahil, Satveer K., Hassi, Niina Karoliina, Wohnhaas, Christian T., Burden, A. David, Griffiths, Christopher E.M., Ingram, John R., Levell, Nick J., Parslew, Richard, Pink, Andrew E., Reynolds, Nick J., Warren, Richard B., Visvanathan, Sudha, Baum, Patrick, Barker, Jonathan N., Smith, Catherine H., Capon, Francesca

“…Palmoplantar pustulosis (PPP) is a severe inflammatory skin disorder characterized by eruptions of painful, neutrophil-filled pustules on the palms and soles…”
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AP1S3 Mutations Are Associated with Pustular Psoriasis and Impaired Toll-like Receptor 3 Trafficking by Setta-Kaffetzi, Niovi, Simpson, Michael A., Navarini, Alexander A., Patel, Varsha M., Lu, Hui-Chun, Allen, Michael H., Duckworth, Michael, Bachelez, Hervé, Burden, A. David, Choon, Siew-Eng, Griffiths, Christopher E.M., Kirby, Brian, Kolios, Antonios, Seyger, Marieke M.B., Prins, Christa, Smahi, Asma, Trembath, Richard C., Fraternali, Franca, Smith, Catherine H., Barker, Jonathan N., Capon, Francesca

“…Adaptor protein complex 1 (AP-1) is an evolutionary conserved heterotetramer that promotes vesicular trafficking between the trans-Golgi network and the…”
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Mutations in the γ-Secretase Genes NCSTN, PSENEN, and PSEN1 Underlie Rare Forms of Hidradenitis Suppurativa (Acne Inversa) by Pink, Andrew E., Simpson, Michael A., Desai, Nemesha, Dafou, Dimitra, Hills, Alison, Mortimer, Peter, Smith, Catherine H., Trembath, Richard C., Barker, Jonathan N.W.

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Genome-wide association meta-analysis identifies 29 new acne susceptibility loci by Mitchell, Brittany L., Saklatvala, Jake R., Dand, Nick, Hagenbeek, Fiona A., Li, Xin, Min, Josine L., Thomas, Laurent, Bartels, Meike, Jan Hottenga, Jouke, Lupton, Michelle K., Boomsma, Dorret I., Dong, Xianjun, Hveem, Kristian, Løset, Mari, Martin, Nicholas G., Barker, Jonathan N., Han, Jiali, Smith, Catherine H., Rentería, Miguel E., Simpson, Michael A.

“…Acne vulgaris is a highly heritable skin disorder that primarily impacts facial skin. Severely inflamed lesions may leave permanent scars that have been…”
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Rare Pathogenic Variants in IL36RN Underlie a Spectrum of Psoriasis-Associated Pustular Phenotypes by Setta-Kaffetzi, Niovi, Navarini, Alexander A., Patel, Varsha M., Pullabhatla, Venu, Pink, Andrew E., Choon, Siew-Eng, Allen, Michael A., Burden, A David, Griffiths, Christopher E.M., Seyger, Marieke M.B., Kirby, Brian, Trembath, Richard C., Simpson, Michael A., Smith, Catherine H., Capon, Francesca, Barker, Jonathan N.

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Psoriasis and Other Complex Trait Dermatoses: From Loci to Functional Pathways by Capon, Francesca, Burden, A David, Trembath, Richard C., Barker, Jonathan N.

“…Driven by advances in molecular genetic technologies and statistical analysis methodologies, there have been huge strides taken in dissecting the complex…”
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Application of information theoretic feature selection and machine learning methods for the development of genetic risk prediction models by Jalali-najafabadi, Farideh, Stadler, Michael, Dand, Nick, Jadon, Deepak, Soomro, Mehreen, Ho, Pauline, Marzo-Ortega, Helen, Helliwell, Philip, Korendowych, Eleanor, Simpson, Michael A., Packham, Jonathan, Smith, Catherine H., Barker, Jonathan N., McHugh, Neil, Warren, Richard B., Barton, Anne, Bowes, John

“…In view of the growth of clinical risk prediction models using genetic data, there is an increasing need for studies that use appropriate methods to select the…”
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Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci by Ellinghaus, David, Jostins, Luke, Spain, Sarah L, Cortes, Adrian, Bethune, Jörn, Han, Buhm, Park, Yu Rang, Raychaudhuri, Soumya, Pouget, Jennie G, Hübenthal, Matthias, Folseraas, Trine, Wang, Yunpeng, Esko, Tonu, Metspalu, Andres, Westra, Harm-Jan, Franke, Lude, Pers, Tune H, Weersma, Rinse K, Collij, Valerie, D'Amato, Mauro, Halfvarson, Jonas, Jensen, Anders Boeck, Lieb, Wolfgang, Degenhardt, Franziska, Forstner, Andreas J, Hofmann, Andrea, Schreiber, Stefan, Mrowietz, Ulrich, Juran, Brian D, Lazaridis, Konstantinos N, Brunak, Søren, Dale, Anders M, Trembath, Richard C, Weidinger, Stephan, Weichenthal, Michael, Ellinghaus, Eva, Elder, James T, Barker, Jonathan N W N, Andreassen, Ole A, McGovern, Dermot P, Karlsen, Tom H, Barrett, Jeffrey C, Parkes, Miles, Brown, Matthew A, Franke, Andre

“…David Ellinghaus and colleagues report a combined association analysis of five chronic inflammatory diseases. They identify 27 new associations and highlight…”
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Manuka honey activates the aryl hydrocarbon receptor: Implications for skin inflammation by Alangari, Abdullah A., Ashoori, Matin D., Alwan, Wisam, Dawe, Hannah R., Stockinger, Brigitta, Barker, Jonathan N., Wincent, Emma, Di Meglio, Paola

“…Manuka honey (MH) is a complex nutritional material with antimicrobial, antioxidant and anti-inflammatory activity. We have previously shown that MH down…”
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IL36RN mutations define a severe autoinflammatory phenotype of generalized pustular psoriasis by Hussain, Safia, BSc, Berki, Dorottya M., BSc, Choon, Siew-Eng, MRCP, Burden, A. David, MD, FRCP, Allen, Michael H., PhD, Arostegui, Juan I., MD, PhD, Chaves, Antonio, MD, Duckworth, Michael, Irvine, Alan D., MD, Mockenhaupt, Maja, MD, PhD, Navarini, Alexander A., MD, PhD, Seyger, Marieke M.B., MD, PhD, Soler-Palacin, Pere, MD, PhD, Prins, Christa, MD, Valeyrie-Allanore, Laurence, MD, Vicente, M. Asuncion, MD, Trembath, Richard C., FMedSci, Smith, Catherine H., MD, FRCP, Barker, Jonathan N., MD, FRCP, Capon, Francesca, PhD

“…Because information on age of onset, systemic involvement, and PV concurrence was available for 99.6%, 72.1%, and 86.7% of cases, we compared these features in…”
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Update on psoriasis immunopathogenesis and targeted immunotherapy by Mahil, Satveer K., Capon, Francesca, Barker, Jonathan N.

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Systematic review of deep learning image analyses for the diagnosis and monitoring of skin disease by Choy, Shern Ping, Kim, Byung Jin, Paolino, Alexandra, Tan, Wei Ren, Lim, Sarah Man Lin, Seo, Jessica, Tan, Sze Ping, Francis, Luc, Tsakok, Teresa, Simpson, Michael, Barker, Jonathan N. W. N., Lynch, Magnus D., Corbett, Mark S., Smith, Catherine H., Mahil, Satveer K.

“…Skin diseases affect one-third of the global population, posing a major healthcare burden. Deep learning may optimise healthcare workflows through processing…”
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